Rapid and Mild Syntheses of Radioiodine-Labeled Radiopharmaceuticals
Radioiodine-labeled pharmaceuticals have been used extensively in diagnostic nuclear medicine. We have developed a rapid and mild method for incorporating radioiodine into functionally substituted molecules. The new process involves the reaction of the radioiodide ion with organoboranes in the prese...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1981-10, Vol.22 (10), p.908-912 |
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| container_issue | 10 |
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| container_title | The Journal of nuclear medicine (1978) |
| container_volume | 22 |
| creator | Kabalka, George W Gooch, E. Eugene Sastry, Kunda A. R |
| description | Radioiodine-labeled pharmaceuticals have been used extensively in diagnostic nuclear medicine. We have developed a rapid and mild method for incorporating radioiodine into functionally substituted molecules. The new process involves the reaction of the radioiodide ion with organoboranes in the presence of gentle oxidizing reagents. The radioiodide is utilized nearly quantitatively in a matter of seconds. The radiochemical yields are excellent, and parallel those obtained when iodine monochloride is reacted with organoboranes. |
| format | Article |
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The radiochemical yields are excellent, and parallel those obtained when iodine monochloride is reacted with organoboranes.</description><subject>Animals</subject><subject>Boranes - chemical synthesis</subject><subject>Boranes - metabolism</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Female</subject><subject>Iodine Radioisotopes</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Tissue Distribution</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotj0tLxDAUhYMo4zj6E4SudFXIo0lulzI-YUQYdR2S5tZm6MumRebfW-isDpzzceA7I2smhUylUvqcrClTLJWSyktyFeOBUqoAYEVWmgNkoNfkcW_74BPb-uQ91D75PLZjhRFj0pXJ3vrQhc6HFtOddVijX7q-skNjC5zGUNg6XpOLcg68OeWGfD8_fW1f093Hy9v2YZdWXMCY5ixnHjnSkmFumfIiQ2BKCoqZ5Uw5AYyKktsSMuW0EAqQOqeRgwWXS7Ehd8tvP3S_E8bRNCEWWNe2xW6KRguVaynYDN6ewMk16E0_hMYOR3PSnvf7Za_CT_UXBjTtVNQ4S83woW04N4yanIL4BylzYYA</recordid><startdate>198110</startdate><enddate>198110</enddate><creator>Kabalka, George W</creator><creator>Gooch, E. 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R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid and Mild Syntheses of Radioiodine-Labeled Radiopharmaceuticals</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>1981-10</date><risdate>1981</risdate><volume>22</volume><issue>10</issue><spage>908</spage><epage>912</epage><pages>908-912</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><abstract>Radioiodine-labeled pharmaceuticals have been used extensively in diagnostic nuclear medicine. We have developed a rapid and mild method for incorporating radioiodine into functionally substituted molecules. The new process involves the reaction of the radioiodide ion with organoboranes in the presence of gentle oxidizing reagents. The radioiodide is utilized nearly quantitatively in a matter of seconds. 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| ispartof | The Journal of nuclear medicine (1978), 1981-10, Vol.22 (10), p.908-912 |
| issn | 0161-5505 1535-5667 |
| language | eng |
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| source | MEDLINE; EZB Electronic Journals Library |
| subjects | Animals Boranes - chemical synthesis Boranes - metabolism Chemical Phenomena Chemistry Female Iodine Radioisotopes Rats Rats, Inbred Strains Tissue Distribution |
| title | Rapid and Mild Syntheses of Radioiodine-Labeled Radiopharmaceuticals |
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