Urinary pregnanetriol excretion in hirsutism
Eighteen consecutive hirsute women attending an endocrine clinic have been studied by measurement of the urinary pregnanetriol excretion before and following the concurrent administration of corticotrophin and metyrapone. An abnormal increment in pregnanetriol excretion was observed in 11 of these 1...
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| Veröffentlicht in: | Clinica chimica acta 1977-10, Vol.80 (2), p.373-379 |
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| container_title | Clinica chimica acta |
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| creator | Hoff, W.Van't Bicknell, E.J. Horrocks, P.M. Fleetwood, J.A. Inthuprapa, M. Hall, R. |
| description | Eighteen consecutive hirsute women attending an endocrine clinic have been studied by measurement of the urinary pregnanetriol excretion before and following the concurrent administration of corticotrophin and metyrapone. An abnormal increment in pregnanetriol excretion was observed in 11 of these 18 patients. It is suggested that this is evidence that an adrenal abnormality, probably operative at the 21-hydroxylase level, might be a factor responsible for the hirsutism in these 11 patients. Five adrenalectomized women who were also studied showed no significant increase in urinary pregnanetriol excretion in response to concurrent corticotrophin and metyrapone administration. |
| doi_str_mv | 10.1016/0009-8981(77)90046-8 |
| format | Article |
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An abnormal increment in pregnanetriol excretion was observed in 11 of these 18 patients. It is suggested that this is evidence that an adrenal abnormality, probably operative at the 21-hydroxylase level, might be a factor responsible for the hirsutism in these 11 patients. Five adrenalectomized women who were also studied showed no significant increase in urinary pregnanetriol excretion in response to concurrent corticotrophin and metyrapone administration.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/0009-8981(77)90046-8</identifier><identifier>PMID: 199379</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adrenalectomy ; Adrenocorticotropic Hormone ; Adult ; Female ; Hirsutism - urine ; Humans ; Metyrapone ; Middle Aged ; Pregnanetriol - urine ; Time Factors</subject><ispartof>Clinica chimica acta, 1977-10, Vol.80 (2), p.373-379</ispartof><rights>1977</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-e886c2fc5ed8bd637d73faa465745b860fc2c762a6432bb85ccb4b52316417233</citedby><cites>FETCH-LOGICAL-c356t-e886c2fc5ed8bd637d73faa465745b860fc2c762a6432bb85ccb4b52316417233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0009-8981(77)90046-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/199379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoff, W.Van't</creatorcontrib><creatorcontrib>Bicknell, E.J.</creatorcontrib><creatorcontrib>Horrocks, P.M.</creatorcontrib><creatorcontrib>Fleetwood, J.A.</creatorcontrib><creatorcontrib>Inthuprapa, M.</creatorcontrib><creatorcontrib>Hall, R.</creatorcontrib><title>Urinary pregnanetriol excretion in hirsutism</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>Eighteen consecutive hirsute women attending an endocrine clinic have been studied by measurement of the urinary pregnanetriol excretion before and following the concurrent administration of corticotrophin and metyrapone. An abnormal increment in pregnanetriol excretion was observed in 11 of these 18 patients. It is suggested that this is evidence that an adrenal abnormality, probably operative at the 21-hydroxylase level, might be a factor responsible for the hirsutism in these 11 patients. Five adrenalectomized women who were also studied showed no significant increase in urinary pregnanetriol excretion in response to concurrent corticotrophin and metyrapone administration.</description><subject>Adrenalectomy</subject><subject>Adrenocorticotropic Hormone</subject><subject>Adult</subject><subject>Female</subject><subject>Hirsutism - urine</subject><subject>Humans</subject><subject>Metyrapone</subject><subject>Middle Aged</subject><subject>Pregnanetriol - urine</subject><subject>Time Factors</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kElLBDEQhYO4jaP_YA59EgVbs3WWiyCDGwx4cc6hk67WSC9j0i36783MiN48FUW996j3ITQj-JJgIq4wxjpXWpEzKc81xlzkagdNiJIsZ1zTXTT5lRyioxjf0sqxIAdon2jNpJ6gi2XwXRm-slWAl67sYAi-bzL4dAEG33eZ77JXH-I4-Ngeo726bCKc_MwpWt7dPs8f8sXT_eP8ZpE7VoghB6WEo7UroFK2EkxWktVlyUUheWGVwLWjTgpaCs6otapwznJbUEYEJ5IyNkWn29xV6N9HiINpfXTQNOm_foxGMqFTlkxCvhW60McYoDar4NtUxxBs1ozMGoBZAzBSmg0jo5Jt9pM_2haqP9MGSjpfb8-QOn54CCY6D52Dygdwg6l6_3_-N6hrdRg</recordid><startdate>19771015</startdate><enddate>19771015</enddate><creator>Hoff, W.Van't</creator><creator>Bicknell, E.J.</creator><creator>Horrocks, P.M.</creator><creator>Fleetwood, J.A.</creator><creator>Inthuprapa, M.</creator><creator>Hall, R.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19771015</creationdate><title>Urinary pregnanetriol excretion in hirsutism</title><author>Hoff, W.Van't ; Bicknell, E.J. ; Horrocks, P.M. ; Fleetwood, J.A. ; Inthuprapa, M. ; Hall, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-e886c2fc5ed8bd637d73faa465745b860fc2c762a6432bb85ccb4b52316417233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Adrenalectomy</topic><topic>Adrenocorticotropic Hormone</topic><topic>Adult</topic><topic>Female</topic><topic>Hirsutism - urine</topic><topic>Humans</topic><topic>Metyrapone</topic><topic>Middle Aged</topic><topic>Pregnanetriol - urine</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoff, W.Van't</creatorcontrib><creatorcontrib>Bicknell, E.J.</creatorcontrib><creatorcontrib>Horrocks, P.M.</creatorcontrib><creatorcontrib>Fleetwood, J.A.</creatorcontrib><creatorcontrib>Inthuprapa, M.</creatorcontrib><creatorcontrib>Hall, R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoff, W.Van't</au><au>Bicknell, E.J.</au><au>Horrocks, P.M.</au><au>Fleetwood, J.A.</au><au>Inthuprapa, M.</au><au>Hall, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary pregnanetriol excretion in hirsutism</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>1977-10-15</date><risdate>1977</risdate><volume>80</volume><issue>2</issue><spage>373</spage><epage>379</epage><pages>373-379</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>Eighteen consecutive hirsute women attending an endocrine clinic have been studied by measurement of the urinary pregnanetriol excretion before and following the concurrent administration of corticotrophin and metyrapone. An abnormal increment in pregnanetriol excretion was observed in 11 of these 18 patients. It is suggested that this is evidence that an adrenal abnormality, probably operative at the 21-hydroxylase level, might be a factor responsible for the hirsutism in these 11 patients. Five adrenalectomized women who were also studied showed no significant increase in urinary pregnanetriol excretion in response to concurrent corticotrophin and metyrapone administration.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>199379</pmid><doi>10.1016/0009-8981(77)90046-8</doi><tpages>7</tpages></addata></record> |
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| ispartof | Clinica chimica acta, 1977-10, Vol.80 (2), p.373-379 |
| issn | 0009-8981 1873-3492 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adrenalectomy Adrenocorticotropic Hormone Adult Female Hirsutism - urine Humans Metyrapone Middle Aged Pregnanetriol - urine Time Factors |
| title | Urinary pregnanetriol excretion in hirsutism |
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