Toluene concentrations in various tissues of rats after inhalation and oral administration
The uptake, distribution, and elimination of 3H-toluene in various tissues of rats were studied after inhalation or after gastric intubation. The maximum radioactivity was measured 2--3 h after gastric intubation in tissues, except in white adipose tissue, where the peak radioactivity was reached at...
Gespeichert in:
| Veröffentlicht in: | Archives of toxicology 1977-09, Vol.38 (3), p.169-176 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 176 |
|---|---|
| container_issue | 3 |
| container_start_page | 169 |
| container_title | Archives of toxicology |
| container_volume | 38 |
| creator | Pyykkö, K Tähti, H Vapaatalo, H |
| description | The uptake, distribution, and elimination of 3H-toluene in various tissues of rats were studied after inhalation or after gastric intubation. The maximum radioactivity was measured 2--3 h after gastric intubation in tissues, except in white adipose tissue, where the peak radioactivity was reached at 5 h. After inhalation exposure, the uptake to various tissues was very rapid. The maximum radioactivity in most tissues was reached in 15--30 min. The accumulation was slowest in white adipose tissue, where it took 1--2 h. The radioactivity in tissues decreased after inhalation exposure more rapidly than after gastric intubation. Brown adipose tissue and white adipose tissue were different from other tissues in their ability to retain toluene. Twenty-four hours after exposures, only 1% or less of the initial radioactivity was found in tissues other than white adipose tissue, in which the corresponding value was 3.5--5%. The results show a very rapid absorption and distribution of toluene after inhalation and a retention of radioactivity in white adipose tissue. After oral ingestion the distribution showed a similar but much slower pattern. |
| doi_str_mv | 10.1007/BF00293651 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73692533</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73692533</sourcerecordid><originalsourceid>FETCH-LOGICAL-c281t-370e241834c772c5022ec6e8af8a0fa4eea4bc5f28b38ec20a59d63208e2ae8d3</originalsourceid><addsrcrecordid>eNpFkL1PwzAQRy3EVykszAyeGJACZzuJnREqCkiVWMrCEl2dizBK7GKnSPz3BFrBdMM9Pf30GDsXcC0A9M3dHEBWqizEHpuIXMkMtDL7bAIqh6zQpThmJym9AwhpKnXEDgtttIQJe12GbkOeuA3ekh8iDi74xJ3nnxhd2CQ-uJQ2lHho-fhNHNuB4gi8YfcLc_QNDxE7jk3vvEs7ySk7aLFLdLa7U_Yyv1_OHrPF88PT7HaRWWnEkCkNJHNhVG61lrYAKcmWZLA1CC3mRJivbNFKs1KGrAQsqqZUEgxJJNOoKbvcetcxfIxDh7p3yVLXoadxf61VWclCqRG82oI2hpQitfU6uh7jVy2g_ulY_3cc4YuddbPqqflDt-HUN-B3bnU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73692533</pqid></control><display><type>article</type><title>Toluene concentrations in various tissues of rats after inhalation and oral administration</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Pyykkö, K ; Tähti, H ; Vapaatalo, H</creator><creatorcontrib>Pyykkö, K ; Tähti, H ; Vapaatalo, H</creatorcontrib><description>The uptake, distribution, and elimination of 3H-toluene in various tissues of rats were studied after inhalation or after gastric intubation. The maximum radioactivity was measured 2--3 h after gastric intubation in tissues, except in white adipose tissue, where the peak radioactivity was reached at 5 h. After inhalation exposure, the uptake to various tissues was very rapid. The maximum radioactivity in most tissues was reached in 15--30 min. The accumulation was slowest in white adipose tissue, where it took 1--2 h. The radioactivity in tissues decreased after inhalation exposure more rapidly than after gastric intubation. Brown adipose tissue and white adipose tissue were different from other tissues in their ability to retain toluene. Twenty-four hours after exposures, only 1% or less of the initial radioactivity was found in tissues other than white adipose tissue, in which the corresponding value was 3.5--5%. The results show a very rapid absorption and distribution of toluene after inhalation and a retention of radioactivity in white adipose tissue. After oral ingestion the distribution showed a similar but much slower pattern.</description><identifier>ISSN: 0340-5761</identifier><identifier>EISSN: 1432-0738</identifier><identifier>DOI: 10.1007/BF00293651</identifier><identifier>PMID: 578720</identifier><language>eng</language><publisher>Germany</publisher><subject>Adipose Tissue - metabolism ; Administration, Oral ; Adrenal Glands - metabolism ; Animals ; Bone Marrow - metabolism ; Liver - metabolism ; Male ; Muscles - metabolism ; Myocardium - metabolism ; Rats ; Spleen - metabolism ; Thyroid Gland - metabolism ; Toluene - administration & dosage ; Toluene - metabolism</subject><ispartof>Archives of toxicology, 1977-09, Vol.38 (3), p.169-176</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c281t-370e241834c772c5022ec6e8af8a0fa4eea4bc5f28b38ec20a59d63208e2ae8d3</citedby><cites>FETCH-LOGICAL-c281t-370e241834c772c5022ec6e8af8a0fa4eea4bc5f28b38ec20a59d63208e2ae8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/578720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pyykkö, K</creatorcontrib><creatorcontrib>Tähti, H</creatorcontrib><creatorcontrib>Vapaatalo, H</creatorcontrib><title>Toluene concentrations in various tissues of rats after inhalation and oral administration</title><title>Archives of toxicology</title><addtitle>Arch Toxicol</addtitle><description>The uptake, distribution, and elimination of 3H-toluene in various tissues of rats were studied after inhalation or after gastric intubation. The maximum radioactivity was measured 2--3 h after gastric intubation in tissues, except in white adipose tissue, where the peak radioactivity was reached at 5 h. After inhalation exposure, the uptake to various tissues was very rapid. The maximum radioactivity in most tissues was reached in 15--30 min. The accumulation was slowest in white adipose tissue, where it took 1--2 h. The radioactivity in tissues decreased after inhalation exposure more rapidly than after gastric intubation. Brown adipose tissue and white adipose tissue were different from other tissues in their ability to retain toluene. Twenty-four hours after exposures, only 1% or less of the initial radioactivity was found in tissues other than white adipose tissue, in which the corresponding value was 3.5--5%. The results show a very rapid absorption and distribution of toluene after inhalation and a retention of radioactivity in white adipose tissue. After oral ingestion the distribution showed a similar but much slower pattern.</description><subject>Adipose Tissue - metabolism</subject><subject>Administration, Oral</subject><subject>Adrenal Glands - metabolism</subject><subject>Animals</subject><subject>Bone Marrow - metabolism</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Muscles - metabolism</subject><subject>Myocardium - metabolism</subject><subject>Rats</subject><subject>Spleen - metabolism</subject><subject>Thyroid Gland - metabolism</subject><subject>Toluene - administration & dosage</subject><subject>Toluene - metabolism</subject><issn>0340-5761</issn><issn>1432-0738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkL1PwzAQRy3EVykszAyeGJACZzuJnREqCkiVWMrCEl2dizBK7GKnSPz3BFrBdMM9Pf30GDsXcC0A9M3dHEBWqizEHpuIXMkMtDL7bAIqh6zQpThmJym9AwhpKnXEDgtttIQJe12GbkOeuA3ekh8iDi74xJ3nnxhd2CQ-uJQ2lHho-fhNHNuB4gi8YfcLc_QNDxE7jk3vvEs7ySk7aLFLdLa7U_Yyv1_OHrPF88PT7HaRWWnEkCkNJHNhVG61lrYAKcmWZLA1CC3mRJivbNFKs1KGrAQsqqZUEgxJJNOoKbvcetcxfIxDh7p3yVLXoadxf61VWclCqRG82oI2hpQitfU6uh7jVy2g_ulY_3cc4YuddbPqqflDt-HUN-B3bnU</recordid><startdate>19770928</startdate><enddate>19770928</enddate><creator>Pyykkö, K</creator><creator>Tähti, H</creator><creator>Vapaatalo, H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19770928</creationdate><title>Toluene concentrations in various tissues of rats after inhalation and oral administration</title><author>Pyykkö, K ; Tähti, H ; Vapaatalo, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-370e241834c772c5022ec6e8af8a0fa4eea4bc5f28b38ec20a59d63208e2ae8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Adipose Tissue - metabolism</topic><topic>Administration, Oral</topic><topic>Adrenal Glands - metabolism</topic><topic>Animals</topic><topic>Bone Marrow - metabolism</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Muscles - metabolism</topic><topic>Myocardium - metabolism</topic><topic>Rats</topic><topic>Spleen - metabolism</topic><topic>Thyroid Gland - metabolism</topic><topic>Toluene - administration & dosage</topic><topic>Toluene - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pyykkö, K</creatorcontrib><creatorcontrib>Tähti, H</creatorcontrib><creatorcontrib>Vapaatalo, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pyykkö, K</au><au>Tähti, H</au><au>Vapaatalo, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toluene concentrations in various tissues of rats after inhalation and oral administration</atitle><jtitle>Archives of toxicology</jtitle><addtitle>Arch Toxicol</addtitle><date>1977-09-28</date><risdate>1977</risdate><volume>38</volume><issue>3</issue><spage>169</spage><epage>176</epage><pages>169-176</pages><issn>0340-5761</issn><eissn>1432-0738</eissn><abstract>The uptake, distribution, and elimination of 3H-toluene in various tissues of rats were studied after inhalation or after gastric intubation. The maximum radioactivity was measured 2--3 h after gastric intubation in tissues, except in white adipose tissue, where the peak radioactivity was reached at 5 h. After inhalation exposure, the uptake to various tissues was very rapid. The maximum radioactivity in most tissues was reached in 15--30 min. The accumulation was slowest in white adipose tissue, where it took 1--2 h. The radioactivity in tissues decreased after inhalation exposure more rapidly than after gastric intubation. Brown adipose tissue and white adipose tissue were different from other tissues in their ability to retain toluene. Twenty-four hours after exposures, only 1% or less of the initial radioactivity was found in tissues other than white adipose tissue, in which the corresponding value was 3.5--5%. The results show a very rapid absorption and distribution of toluene after inhalation and a retention of radioactivity in white adipose tissue. After oral ingestion the distribution showed a similar but much slower pattern.</abstract><cop>Germany</cop><pmid>578720</pmid><doi>10.1007/BF00293651</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-5761 |
| ispartof | Archives of toxicology, 1977-09, Vol.38 (3), p.169-176 |
| issn | 0340-5761 1432-0738 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73692533 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adipose Tissue - metabolism Administration, Oral Adrenal Glands - metabolism Animals Bone Marrow - metabolism Liver - metabolism Male Muscles - metabolism Myocardium - metabolism Rats Spleen - metabolism Thyroid Gland - metabolism Toluene - administration & dosage Toluene - metabolism |
| title | Toluene concentrations in various tissues of rats after inhalation and oral administration |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T13%3A55%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Toluene%20concentrations%20in%20various%20tissues%20of%20rats%20after%20inhalation%20and%20oral%20administration&rft.jtitle=Archives%20of%20toxicology&rft.au=Pyykk%C3%B6,%20K&rft.date=1977-09-28&rft.volume=38&rft.issue=3&rft.spage=169&rft.epage=176&rft.pages=169-176&rft.issn=0340-5761&rft.eissn=1432-0738&rft_id=info:doi/10.1007/BF00293651&rft_dat=%3Cproquest_cross%3E73692533%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73692533&rft_id=info:pmid/578720&rfr_iscdi=true |