Wheat gluten challenge in schizophrenic patients
Eight chronic schizophrenic patients were maintained on a diet free of gluten, cereal grains, and milk (CM-F diet) and challenged in a double- blind manner with dietary wheat gluten and placebo. While on the CM-F diet, each patient received a daily challenge of 30 g of gluten for 5 weeks and a place...
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| Veröffentlicht in: | The American journal of psychiatry 1981-09, Vol.138 (9), p.1208-1211 |
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| container_issue | 9 |
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| container_title | The American journal of psychiatry |
| container_volume | 138 |
| creator | Potkin, S G Weinberger, D Kleinman, J Nasrallah, H Luchins, D Bigelow, L Linnoila, M Fischer, S H Bjornsson, T D Carman, J Gillin, J C Wyatt, R J |
| description | Eight chronic schizophrenic patients were maintained on a diet free of
gluten, cereal grains, and milk (CM-F diet) and challenged in a double-
blind manner with dietary wheat gluten and placebo. While on the CM-F diet,
each patient received a daily challenge of 30 g of gluten for 5 weeks and a
placebo challenge for 8 weeks. No deterioration in clinical status as
measured by the BPRS was noted on gluten challenge. Serum alpha 1 acid
glycoprotein measurement demonstrated no evidence of inflammatory response
to gluten challenge. The data suggest that sensitivity to dietary gluten is
not characteristic of young chronic schizophrenic patients. |
| doi_str_mv | 10.1176/ajp.138.9.1208 |
| format | Article |
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gluten, cereal grains, and milk (CM-F diet) and challenged in a double-
blind manner with dietary wheat gluten and placebo. While on the CM-F diet,
each patient received a daily challenge of 30 g of gluten for 5 weeks and a
placebo challenge for 8 weeks. No deterioration in clinical status as
measured by the BPRS was noted on gluten challenge. Serum alpha 1 acid
glycoprotein measurement demonstrated no evidence of inflammatory response
to gluten challenge. The data suggest that sensitivity to dietary gluten is
not characteristic of young chronic schizophrenic patients.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/ajp.138.9.1208</identifier><identifier>PMID: 7270725</identifier><language>eng</language><publisher>United States: American Psychiatric Publishing</publisher><subject>Adult ; Double-Blind Method ; Female ; Glutens - administration & dosage ; Glutens - adverse effects ; Humans ; Male ; Orosomucoid - blood ; Psychiatric Status Rating Scales ; Schizophrenia - diet therapy ; Schizophrenia - etiology ; Triticum</subject><ispartof>The American journal of psychiatry, 1981-09, Vol.138 (9), p.1208-1211</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a354t-25619c0c14fab33ecf4955393f56b3a7e92dd166dde53ba4d6d4a888baca79d83</citedby><cites>FETCH-LOGICAL-a354t-25619c0c14fab33ecf4955393f56b3a7e92dd166dde53ba4d6d4a888baca79d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/ajp.138.9.1208$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/ajp.138.9.1208$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,776,780,2846,21608,27846,27901,27902,77533,77534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7270725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Potkin, S G</creatorcontrib><creatorcontrib>Weinberger, D</creatorcontrib><creatorcontrib>Kleinman, J</creatorcontrib><creatorcontrib>Nasrallah, H</creatorcontrib><creatorcontrib>Luchins, D</creatorcontrib><creatorcontrib>Bigelow, L</creatorcontrib><creatorcontrib>Linnoila, M</creatorcontrib><creatorcontrib>Fischer, S H</creatorcontrib><creatorcontrib>Bjornsson, T D</creatorcontrib><creatorcontrib>Carman, J</creatorcontrib><creatorcontrib>Gillin, J C</creatorcontrib><creatorcontrib>Wyatt, R J</creatorcontrib><title>Wheat gluten challenge in schizophrenic patients</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>Eight chronic schizophrenic patients were maintained on a diet free of
gluten, cereal grains, and milk (CM-F diet) and challenged in a double-
blind manner with dietary wheat gluten and placebo. While on the CM-F diet,
each patient received a daily challenge of 30 g of gluten for 5 weeks and a
placebo challenge for 8 weeks. No deterioration in clinical status as
measured by the BPRS was noted on gluten challenge. Serum alpha 1 acid
glycoprotein measurement demonstrated no evidence of inflammatory response
to gluten challenge. The data suggest that sensitivity to dietary gluten is
not characteristic of young chronic schizophrenic patients.</description><subject>Adult</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Glutens - administration & dosage</subject><subject>Glutens - adverse effects</subject><subject>Humans</subject><subject>Male</subject><subject>Orosomucoid - blood</subject><subject>Psychiatric Status Rating Scales</subject><subject>Schizophrenia - diet therapy</subject><subject>Schizophrenia - etiology</subject><subject>Triticum</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNptkEtLw0AQxxdRaq1evQkBwYsk7iP7OkrxBQUvit6Wye6mSUmTmE0O-ulNaBERT8Pwf8zwQ-ic4IQQKW5g0yaEqUQnhGJ1gOaEMx5LStUhmmOMaaw5ez9GJyFsxhUzSWdoJqnEkvI5wm-Fhz5aV0Pv68gWUFW-XvuorKNgi_KraYvO16WNWuhLX_fhFB3lUAV_tp8L9Hp_97J8jFfPD0_L21UMjKd9TLkg2mJL0hwyxrzNU8050yznImMgvabOESGc85xlkDrhUlBKZWBBaqfYAl3tetuu-Rh86M22DNZXFdS-GYKRTGhKCR6Nl3-Mm2bo6vE3QxjBAguNp7pk57JdE0Lnc9N25Ra6T0OwmUCaEeQYUEabCeQYuNjXDtnWux_7ntyoX-90aNvy18n_274BLFd7fA</recordid><startdate>198109</startdate><enddate>198109</enddate><creator>Potkin, S G</creator><creator>Weinberger, D</creator><creator>Kleinman, J</creator><creator>Nasrallah, H</creator><creator>Luchins, D</creator><creator>Bigelow, L</creator><creator>Linnoila, M</creator><creator>Fischer, S H</creator><creator>Bjornsson, T D</creator><creator>Carman, J</creator><creator>Gillin, J C</creator><creator>Wyatt, R J</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>HAWNG</scope><scope>HBMBR</scope><scope>IBDFT</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>7X8</scope></search><sort><creationdate>198109</creationdate><title>Wheat gluten challenge in schizophrenic patients</title><author>Potkin, S G ; Weinberger, D ; Kleinman, J ; Nasrallah, H ; Luchins, D ; Bigelow, L ; Linnoila, M ; Fischer, S H ; Bjornsson, T D ; Carman, J ; Gillin, J C ; Wyatt, R J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a354t-25619c0c14fab33ecf4955393f56b3a7e92dd166dde53ba4d6d4a888baca79d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Adult</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Glutens - 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gluten, cereal grains, and milk (CM-F diet) and challenged in a double-
blind manner with dietary wheat gluten and placebo. While on the CM-F diet,
each patient received a daily challenge of 30 g of gluten for 5 weeks and a
placebo challenge for 8 weeks. No deterioration in clinical status as
measured by the BPRS was noted on gluten challenge. Serum alpha 1 acid
glycoprotein measurement demonstrated no evidence of inflammatory response
to gluten challenge. The data suggest that sensitivity to dietary gluten is
not characteristic of young chronic schizophrenic patients.</abstract><cop>United States</cop><pub>American Psychiatric Publishing</pub><pmid>7270725</pmid><doi>10.1176/ajp.138.9.1208</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-953X |
| ispartof | The American journal of psychiatry, 1981-09, Vol.138 (9), p.1208-1211 |
| issn | 0002-953X 1535-7228 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73692210 |
| source | MEDLINE; Psychiatry Legacy Collection Online Journals 1844-1996; Periodicals Index Online |
| subjects | Adult Double-Blind Method Female Glutens - administration & dosage Glutens - adverse effects Humans Male Orosomucoid - blood Psychiatric Status Rating Scales Schizophrenia - diet therapy Schizophrenia - etiology Triticum |
| title | Wheat gluten challenge in schizophrenic patients |
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