A Model for Local Accumulation of Bone Imaging Radiopharmaceuticals
A simple models, having phenomenological parameters as variables, is developed for predicting local radioactive tracer accumulation in bone. Blood delivering tracer to one gram of bone is treated as a compartment separate from the remainder of the circulation in order to observe the effects produced...
Gespeichert in:
| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1977-11, Vol.18 (11), p.1106-1111 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1111 |
|---|---|
| container_issue | 11 |
| container_start_page | 1106 |
| container_title | The Journal of nuclear medicine (1978) |
| container_volume | 18 |
| creator | King, Michael A Kilpper, Robert W Weber, David A |
| description | A simple models, having phenomenological parameters as variables, is developed for predicting local radioactive tracer accumulation in bone. Blood delivering tracer to one gram of bone is treated as a compartment separate from the remainder of the circulation in order to observe the effects produced by variations in both bone flow and barrier permeability. Kinetic curves derived by analog computer were obtained for normal and perturbed values of the parameters for F-18 and Ca-47 in a segment of rabbit bone. Apparent confirmation of the predicted influence of decreased blood flow on F-18 deposition was obtained by measuring bone uptake following constriction of the right femoral artery in five rabbits. Such models may prove useful in explaining variations in uptake for different agents, in selecting imaging times, and in correlating uptake patterns with disease. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_73690667</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73690667</sourcerecordid><originalsourceid>FETCH-LOGICAL-h238t-cd1cbbe09a3e3274238529c183f1ce045bba14943aa0d19d127b5e7dee5fafd73</originalsourceid><addsrcrecordid>eNotj01LxDAQhoP4ta7-Aw85iZdCpmna9LgufixUBNFzSZNpm6Vp1rZB_PcGdmHghXmfGXjOyAoEF4nI8-KcrBjkkAjBxDW5mec9YyyXUl6RyxIEk3JFthv67g0OtPUTrbxWA91oHVwY1GL9SH1Ln_yIdOdUZ8eOfipj_aFXk1Maw2LjwXxLLtoYeHfKNfl-ef7aviXVx-tuu6mSPuVySbQB3TTISsWRp0UWlyItNUjegkaWiaZRkJUZV4oZKA2kRSOwMIiiVa0p-Jo8HP8eJv8TcF5qZ2eNw6BG9GGuC56XLHpH8P4EhsahqQ-TdWr6q4_SsX481r3t-l87YT0GPWB0iux-dCBrgDgs5_-PuGGP</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73690667</pqid></control><display><type>article</type><title>A Model for Local Accumulation of Bone Imaging Radiopharmaceuticals</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>King, Michael A ; Kilpper, Robert W ; Weber, David A</creator><creatorcontrib>King, Michael A ; Kilpper, Robert W ; Weber, David A</creatorcontrib><description>A simple models, having phenomenological parameters as variables, is developed for predicting local radioactive tracer accumulation in bone. Blood delivering tracer to one gram of bone is treated as a compartment separate from the remainder of the circulation in order to observe the effects produced by variations in both bone flow and barrier permeability. Kinetic curves derived by analog computer were obtained for normal and perturbed values of the parameters for F-18 and Ca-47 in a segment of rabbit bone. Apparent confirmation of the predicted influence of decreased blood flow on F-18 deposition was obtained by measuring bone uptake following constriction of the right femoral artery in five rabbits. Such models may prove useful in explaining variations in uptake for different agents, in selecting imaging times, and in correlating uptake patterns with disease.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 915088</identifier><language>eng</language><publisher>United States: Soc Nuclear Med</publisher><subject>Animals ; Bone and Bones - diagnostic imaging ; Bone and Bones - metabolism ; Calcium Radioisotopes ; Fluorine - metabolism ; Mathematics ; Models, Biological ; Rabbits ; Radioisotopes ; Radionuclide Imaging</subject><ispartof>The Journal of nuclear medicine (1978), 1977-11, Vol.18 (11), p.1106-1111</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/915088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>King, Michael A</creatorcontrib><creatorcontrib>Kilpper, Robert W</creatorcontrib><creatorcontrib>Weber, David A</creatorcontrib><title>A Model for Local Accumulation of Bone Imaging Radiopharmaceuticals</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>A simple models, having phenomenological parameters as variables, is developed for predicting local radioactive tracer accumulation in bone. Blood delivering tracer to one gram of bone is treated as a compartment separate from the remainder of the circulation in order to observe the effects produced by variations in both bone flow and barrier permeability. Kinetic curves derived by analog computer were obtained for normal and perturbed values of the parameters for F-18 and Ca-47 in a segment of rabbit bone. Apparent confirmation of the predicted influence of decreased blood flow on F-18 deposition was obtained by measuring bone uptake following constriction of the right femoral artery in five rabbits. Such models may prove useful in explaining variations in uptake for different agents, in selecting imaging times, and in correlating uptake patterns with disease.</description><subject>Animals</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>Bone and Bones - metabolism</subject><subject>Calcium Radioisotopes</subject><subject>Fluorine - metabolism</subject><subject>Mathematics</subject><subject>Models, Biological</subject><subject>Rabbits</subject><subject>Radioisotopes</subject><subject>Radionuclide Imaging</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotj01LxDAQhoP4ta7-Aw85iZdCpmna9LgufixUBNFzSZNpm6Vp1rZB_PcGdmHghXmfGXjOyAoEF4nI8-KcrBjkkAjBxDW5mec9YyyXUl6RyxIEk3JFthv67g0OtPUTrbxWA91oHVwY1GL9SH1Ln_yIdOdUZ8eOfipj_aFXk1Maw2LjwXxLLtoYeHfKNfl-ef7aviXVx-tuu6mSPuVySbQB3TTISsWRp0UWlyItNUjegkaWiaZRkJUZV4oZKA2kRSOwMIiiVa0p-Jo8HP8eJv8TcF5qZ2eNw6BG9GGuC56XLHpH8P4EhsahqQ-TdWr6q4_SsX481r3t-l87YT0GPWB0iux-dCBrgDgs5_-PuGGP</recordid><startdate>197711</startdate><enddate>197711</enddate><creator>King, Michael A</creator><creator>Kilpper, Robert W</creator><creator>Weber, David A</creator><general>Soc Nuclear Med</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197711</creationdate><title>A Model for Local Accumulation of Bone Imaging Radiopharmaceuticals</title><author>King, Michael A ; Kilpper, Robert W ; Weber, David A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h238t-cd1cbbe09a3e3274238529c183f1ce045bba14943aa0d19d127b5e7dee5fafd73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Animals</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>Bone and Bones - metabolism</topic><topic>Calcium Radioisotopes</topic><topic>Fluorine - metabolism</topic><topic>Mathematics</topic><topic>Models, Biological</topic><topic>Rabbits</topic><topic>Radioisotopes</topic><topic>Radionuclide Imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>King, Michael A</creatorcontrib><creatorcontrib>Kilpper, Robert W</creatorcontrib><creatorcontrib>Weber, David A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>King, Michael A</au><au>Kilpper, Robert W</au><au>Weber, David A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Model for Local Accumulation of Bone Imaging Radiopharmaceuticals</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>1977-11</date><risdate>1977</risdate><volume>18</volume><issue>11</issue><spage>1106</spage><epage>1111</epage><pages>1106-1111</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><abstract>A simple models, having phenomenological parameters as variables, is developed for predicting local radioactive tracer accumulation in bone. Blood delivering tracer to one gram of bone is treated as a compartment separate from the remainder of the circulation in order to observe the effects produced by variations in both bone flow and barrier permeability. Kinetic curves derived by analog computer were obtained for normal and perturbed values of the parameters for F-18 and Ca-47 in a segment of rabbit bone. Apparent confirmation of the predicted influence of decreased blood flow on F-18 deposition was obtained by measuring bone uptake following constriction of the right femoral artery in five rabbits. Such models may prove useful in explaining variations in uptake for different agents, in selecting imaging times, and in correlating uptake patterns with disease.</abstract><cop>United States</cop><pub>Soc Nuclear Med</pub><pmid>915088</pmid><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0161-5505 |
| ispartof | The Journal of nuclear medicine (1978), 1977-11, Vol.18 (11), p.1106-1111 |
| issn | 0161-5505 1535-5667 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73690667 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Bone and Bones - diagnostic imaging Bone and Bones - metabolism Calcium Radioisotopes Fluorine - metabolism Mathematics Models, Biological Rabbits Radioisotopes Radionuclide Imaging |
| title | A Model for Local Accumulation of Bone Imaging Radiopharmaceuticals |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T12%3A43%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Model%20for%20Local%20Accumulation%20of%20Bone%20Imaging%20Radiopharmaceuticals&rft.jtitle=The%20Journal%20of%20nuclear%20medicine%20(1978)&rft.au=King,%20Michael%20A&rft.date=1977-11&rft.volume=18&rft.issue=11&rft.spage=1106&rft.epage=1111&rft.pages=1106-1111&rft.issn=0161-5505&rft.eissn=1535-5667&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E73690667%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73690667&rft_id=info:pmid/915088&rfr_iscdi=true |