β-Galactosidase-Neuraminidase Deficiency: Restoration of β-Galactosidase Activity by Protease Inhibitors

β-Galactosidase was partially restored by protease inhibitors, leupeptin, chymo-statin and E-64 in cultured fibroblasts from three patients with β-galactosidase-neuraminidase deficiency. Pepstatin did not activate this enzyme. Neuraminidase was not affected by any of these compounds in the culture m...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 1981-07, Vol.90 (1), p.271-273
Hauptverfasser:	SUZUKI, Yoshiyuki, SAKURABA, Hitoshi, HAYASHI, Kazuyo, SUZUKI, Koichi, IMAHORI, Kazutomo
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Galactosidase - metabolism Cells, Cultured Enzyme Activation Fibroblasts - drug effects Fibroblasts - enzymology Humans Lactose Intolerance - enzymology Neuraminidase - deficiency Protease Inhibitors - pharmacology Skin - drug effects Skin - enzymology
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