Comparative studies on granulation of juxtaglomerular cells of some mammalian kidneys and limitation of the specificity of Bowie staining

Renal juxtaglomerul;tr cell granulation in some mammals was demonstratedby Bowies staining method. Hartroft and llatrofts index was applied to different speciesin one trial. It was high in the mouse and rat, and low in the hamster. These resttlts werecorrelative with those reported by Capelli who measured the renal renin content in sonnemammalian species. In the horse, cow, sheep and guinea pig large grantnles, whiclt werestained by Bowies method, were observed near the glomerular arteriole. Then in themouse these granules were studied by electron microscope. It was observed that large cellswhich contained many heterogenous lysosomes were present in the outer layer of theepithelium of the glomerular capsttle. This observation suggested that the large granulesseen by light microscope might not be juxtaglomerular cell granules, bttt ordinarylysosomes.