The Tyrosine Phosphatase Shp-2 Mediates Intracellular Signaling Initiated by Ret Mutants

The Src homology 2-containing tyrosine phosphatase, Shp-2, is a crucial enzyme that mediates intracellular signaling and is implicated in cell proliferation and differentiation. Here we investigated the involvement of the Shp-2 tyrosine phosphatase in determining the downstream signaling pathways in...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2003-10, Vol.144 (10), p.4298-4305
Hauptverfasser:	D’Alessio, A, Califano, D, Incoronato, M, Santelli, G, Florio, T, Schettini, G, Carlomagno, M. S, Cerchia, L, de Franciscis, V
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animals Biological and medical sciences Cell activation Cell differentiation Cell Differentiation - physiology Cell Line Cell proliferation Cell Survival - physiology Fundamental and applied biological sciences. Psychology Gene expression Glial Cell Line-Derived Neurotrophic Factor Homology Intracellular Intracellular Membranes - physiology Intracellular Signaling Peptides and Proteins Intracellular signalling Kinases Methionine Multiple endocrine neoplasia Mutants Mutation - physiology Nerve Growth Factors - metabolism Oncogene Proteins - genetics Oncogene Proteins - metabolism PC12 Cells - pathology Phosphatase Protein Tyrosine Phosphatase, Non-Receptor Type 11 Protein Tyrosine Phosphatases - metabolism Protein-tyrosine kinase receptors Protein-tyrosine-phosphatase Proto-Oncogene Proteins c-ret Rats Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Receptors Ret protein SHP-2 protein Signal Transduction - physiology Tyrosine Vertebrates: endocrinology
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