Engraftment of retroviral EGFP-transduced bone marrow in mice prevents rejection of EGFP-transgenic skin grafts

We have investigated whether a state of tolerance toward EGFP-expressing skin tissue can be induced by prior establishment of EGFP molecular chimerism by transplant of gene-transduced bone marrow in mice. Irradiated (10 Gy) C57BL/6J mice were transplanted with bone marrow cells transduced with two d...

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Veröffentlicht in:	Molecular therapy 2003-09, Vol.8 (3), p.385-391
Hauptverfasser:	Andersson, Goran, Denaro, Maria, Johnson, Kevin, Morgan, Peter, Sullivan, Angela, Houser, Stuart, Patience, Clive, White-Scharf, Mary E, Down, Julian D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone marrow Bone Marrow - immunology Bone Marrow - metabolism bone marrow transplantation Bone Marrow Transplantation - immunology EGFP Experiments Gene therapy Genes, Reporter Granulocytes Green Fluorescent Proteins immunological tolerance Immunology Kinases Leukocytes Luminescent Proteins - genetics Luminescent Proteins - immunology Luminescent Proteins - metabolism Mice molecular chimerism Plastic surgery retrovirus vector Skin & tissue grafts Skin - immunology Skin - metabolism Skin Transplantation - immunology Stem cell transplantation Time Factors Transduction, Genetic transgene immunogenicity Vectors (Biology)
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