Relationship between tumour growth rate and proteic variations in interstitial subcutaneous fluid and serum: Possible thymic control
Some murine tumours stimulate the proliferation of target cells in diffusion chambers implanted subcutaneously near the tumour. The growth of tumours with or without the property to stimulate the proliferation of target cells was studied in relation to the proteic variations in interstitial subcutan...
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| Veröffentlicht in: | European journal of cancer 1977-09, Vol.13 (9), p.1025-1032 |
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| container_title | European journal of cancer |
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| creator | Vaillier, D. Vaillier, J. Bischoff, P. |
| description | Some murine tumours stimulate the proliferation of target cells in diffusion chambers implanted subcutaneously near the tumour. The growth of tumours with or without the property to stimulate the proliferation of target cells was studied in relation to the proteic variations in interstitial subcutaneous fluid and serum in normal hosts and thymectomized or thymus-deprived hosts.
“Stimulating” tumours were found to exhibit a much faster growth than “non stimulating” tumours, in normal hosts. A significant protein decrease was observed in interstitial fluid of mice bearing “stimulating” tumours as compared to control mice.
In contrast, the analysis of interstitial fluid and serum of mice bearing “non stimulating” tumours revealed a significant proteic increase.
The study of the growth behaviour of these tumours in T-cell deprived mice revealed a deceleration of the “stimulating” tumours, and a heavy acceleration for the “non stimulating” tumours. No proteic variation as compared to control mice was found in interstitial fluid and serum of tumour bearing T-cell deprived mice.
The hypothesis was formulated that some relationship exists between tumour growth rate and proteic variations in interstitial subcutaneous fluid and serum which might be under thymic control. |
| doi_str_mv | 10.1016/0014-2964(77)90182-7 |
| format | Article |
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“Stimulating” tumours were found to exhibit a much faster growth than “non stimulating” tumours, in normal hosts. A significant protein decrease was observed in interstitial fluid of mice bearing “stimulating” tumours as compared to control mice.
In contrast, the analysis of interstitial fluid and serum of mice bearing “non stimulating” tumours revealed a significant proteic increase.
The study of the growth behaviour of these tumours in T-cell deprived mice revealed a deceleration of the “stimulating” tumours, and a heavy acceleration for the “non stimulating” tumours. No proteic variation as compared to control mice was found in interstitial fluid and serum of tumour bearing T-cell deprived mice.
The hypothesis was formulated that some relationship exists between tumour growth rate and proteic variations in interstitial subcutaneous fluid and serum which might be under thymic control.</description><identifier>ISSN: 0014-2964</identifier><identifier>DOI: 10.1016/0014-2964(77)90182-7</identifier><identifier>PMID: 303177</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Extracellular Space - analysis ; Mice ; Mice, Inbred CBA ; Mice, Inbred Strains ; Neoplasms, Experimental ; Proteins - analysis ; Rhabdomyosarcoma - blood ; Rhabdomyosarcoma - metabolism ; T-Lymphocytes - immunology ; Thymus Gland - physiology</subject><ispartof>European journal of cancer, 1977-09, Vol.13 (9), p.1025-1032</ispartof><rights>1977</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c351t-3b7f07595a1d22d41b932a953895cf96a16b3fa32e6a084f3e60cbb91bbfd9bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/303177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vaillier, D.</creatorcontrib><creatorcontrib>Vaillier, J.</creatorcontrib><creatorcontrib>Bischoff, P.</creatorcontrib><title>Relationship between tumour growth rate and proteic variations in interstitial subcutaneous fluid and serum: Possible thymic control</title><title>European journal of cancer</title><addtitle>Eur J Cancer</addtitle><description>Some murine tumours stimulate the proliferation of target cells in diffusion chambers implanted subcutaneously near the tumour. The growth of tumours with or without the property to stimulate the proliferation of target cells was studied in relation to the proteic variations in interstitial subcutaneous fluid and serum in normal hosts and thymectomized or thymus-deprived hosts.
“Stimulating” tumours were found to exhibit a much faster growth than “non stimulating” tumours, in normal hosts. A significant protein decrease was observed in interstitial fluid of mice bearing “stimulating” tumours as compared to control mice.
In contrast, the analysis of interstitial fluid and serum of mice bearing “non stimulating” tumours revealed a significant proteic increase.
The study of the growth behaviour of these tumours in T-cell deprived mice revealed a deceleration of the “stimulating” tumours, and a heavy acceleration for the “non stimulating” tumours. No proteic variation as compared to control mice was found in interstitial fluid and serum of tumour bearing T-cell deprived mice.
The hypothesis was formulated that some relationship exists between tumour growth rate and proteic variations in interstitial subcutaneous fluid and serum which might be under thymic control.</description><subject>Animals</subject><subject>Extracellular Space - analysis</subject><subject>Mice</subject><subject>Mice, Inbred CBA</subject><subject>Mice, Inbred Strains</subject><subject>Neoplasms, Experimental</subject><subject>Proteins - analysis</subject><subject>Rhabdomyosarcoma - blood</subject><subject>Rhabdomyosarcoma - metabolism</subject><subject>T-Lymphocytes - immunology</subject><subject>Thymus Gland - physiology</subject><issn>0014-2964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxTAQhbPw_fgHLrISXVSTpm0aF4JcfIGgiK5Dkk69kba55nHl7v3h9lpxKQwMzMw5nPkQOqLkjBJanRNCiywXVXHC-akgtM4zvoF2_8Y7aC-Ed0LyuijzbbTFCKOc76KvZ-hUtG4Ic7vAGuInwIBj6l3y-M27zzjHXkXAamjwwrsI1uCl8nYSYTuMFcGHaKNVHQ5JmxTVAC4F3HbJNj_KAD71F_jJhWB1BzjOV_1oZNwQvesO0GarugCHv30fvd5cv8zusofH2_vZ1UNmWEljxjRvCS9FqWiT501BtWC5EiWrRWlaUSlaadYqlkOlSF20DCpitBZU67YR2rB9dDz5jo98JAhR9jYY6Lopr-Ssqgsq-HhYTIfGj4k9tHLhba_8SlIi17zlGqxcg5Wcyx_eci07-vVPuofmTzTBHteX0xrGH5cWvAzGwmCgsR5MlI2z__t_A4MXlS0</recordid><startdate>197709</startdate><enddate>197709</enddate><creator>Vaillier, D.</creator><creator>Vaillier, J.</creator><creator>Bischoff, P.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197709</creationdate><title>Relationship between tumour growth rate and proteic variations in interstitial subcutaneous fluid and serum: Possible thymic control</title><author>Vaillier, D. ; Vaillier, J. ; Bischoff, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-3b7f07595a1d22d41b932a953895cf96a16b3fa32e6a084f3e60cbb91bbfd9bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Animals</topic><topic>Extracellular Space - analysis</topic><topic>Mice</topic><topic>Mice, Inbred CBA</topic><topic>Mice, Inbred Strains</topic><topic>Neoplasms, Experimental</topic><topic>Proteins - analysis</topic><topic>Rhabdomyosarcoma - blood</topic><topic>Rhabdomyosarcoma - metabolism</topic><topic>T-Lymphocytes - immunology</topic><topic>Thymus Gland - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vaillier, D.</creatorcontrib><creatorcontrib>Vaillier, J.</creatorcontrib><creatorcontrib>Bischoff, P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vaillier, D.</au><au>Vaillier, J.</au><au>Bischoff, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between tumour growth rate and proteic variations in interstitial subcutaneous fluid and serum: Possible thymic control</atitle><jtitle>European journal of cancer</jtitle><addtitle>Eur J Cancer</addtitle><date>1977-09</date><risdate>1977</risdate><volume>13</volume><issue>9</issue><spage>1025</spage><epage>1032</epage><pages>1025-1032</pages><issn>0014-2964</issn><abstract>Some murine tumours stimulate the proliferation of target cells in diffusion chambers implanted subcutaneously near the tumour. The growth of tumours with or without the property to stimulate the proliferation of target cells was studied in relation to the proteic variations in interstitial subcutaneous fluid and serum in normal hosts and thymectomized or thymus-deprived hosts.
“Stimulating” tumours were found to exhibit a much faster growth than “non stimulating” tumours, in normal hosts. A significant protein decrease was observed in interstitial fluid of mice bearing “stimulating” tumours as compared to control mice.
In contrast, the analysis of interstitial fluid and serum of mice bearing “non stimulating” tumours revealed a significant proteic increase.
The study of the growth behaviour of these tumours in T-cell deprived mice revealed a deceleration of the “stimulating” tumours, and a heavy acceleration for the “non stimulating” tumours. No proteic variation as compared to control mice was found in interstitial fluid and serum of tumour bearing T-cell deprived mice.
The hypothesis was formulated that some relationship exists between tumour growth rate and proteic variations in interstitial subcutaneous fluid and serum which might be under thymic control.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>303177</pmid><doi>10.1016/0014-2964(77)90182-7</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0014-2964 |
| ispartof | European journal of cancer, 1977-09, Vol.13 (9), p.1025-1032 |
| issn | 0014-2964 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Extracellular Space - analysis Mice Mice, Inbred CBA Mice, Inbred Strains Neoplasms, Experimental Proteins - analysis Rhabdomyosarcoma - blood Rhabdomyosarcoma - metabolism T-Lymphocytes - immunology Thymus Gland - physiology |
| title | Relationship between tumour growth rate and proteic variations in interstitial subcutaneous fluid and serum: Possible thymic control |
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