Urinary dopamine and turn bias in traumatized women with and without PTSD symptoms
Turning biases are known to occur in the direction of the brain hemisphere with decreased dopamine (DA). Although elevations in urinary DA have been shown in posttraumatic stress disorder (PTSD), evidence for dysregulation of dopaminergic activity in the brain is lacking. Turn bias and urinary DA le...
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| Veröffentlicht in: | Behavioural brain research 2003-09, Vol.144 (1), p.137-141 |
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| creator | Glover, Dorie A Powers, Mark B Bergman, Lyndsey Smits, Jasper A.J Telch, Michael J Stuber, Margaret |
| description | Turning biases are known to occur in the direction of the brain hemisphere with decreased dopamine (DA). Although elevations in urinary DA have been shown in posttraumatic stress disorder (PTSD), evidence for dysregulation of dopaminergic activity in the brain is lacking. Turn bias and urinary DA levels were examined in mothers of childhood cancer survivors. As expected, cancer trauma mothers with PTSD symptoms (
n=14) had higher urinary DA levels than trauma mothers without PTSD symptoms (
n=7) and controls (
n=8) (
P=0.01). Groups were also significantly different in prevalence of left turn bias (
P=0.03). All controls (100%) showed a left turn bias compared to 75 and 37.5% prevalence among trauma mothers with and without PTSD, respectively. Urinary DA levels and turn bias rates were not correlated. Results lend support for further exploration of DA in traumatized groups with and without PTSD. |
| doi_str_mv | 10.1016/S0166-4328(03)00074-3 |
| format | Article |
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n=14) had higher urinary DA levels than trauma mothers without PTSD symptoms (
n=7) and controls (
n=8) (
P=0.01). Groups were also significantly different in prevalence of left turn bias (
P=0.03). All controls (100%) showed a left turn bias compared to 75 and 37.5% prevalence among trauma mothers with and without PTSD, respectively. Urinary DA levels and turn bias rates were not correlated. Results lend support for further exploration of DA in traumatized groups with and without PTSD.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/S0166-4328(03)00074-3</identifier><identifier>PMID: 12946604</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Analysis of Variance ; Biomarkers ; Chi-Square Distribution ; Child ; Dopamine ; Dopamine - urine ; Female ; Humans ; Lateralization ; Mothers - psychology ; Movement Disorders - metabolism ; Movement Disorders - psychology ; Neoplasms - metabolism ; Neoplasms - physiopathology ; Posttraumatic stress disorder ; Psychiatric Status Rating Scales ; Stress Disorders, Post-Traumatic - psychology ; Stress Disorders, Post-Traumatic - urine ; Survivors ; Trauma ; Turn bias</subject><ispartof>Behavioural brain research, 2003-09, Vol.144 (1), p.137-141</ispartof><rights>2003 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-254cc8104cda40d0a458096639e73541ad7ab7521fbebdbd1e3616f058dd7a1e3</citedby><cites>FETCH-LOGICAL-c423t-254cc8104cda40d0a458096639e73541ad7ab7521fbebdbd1e3616f058dd7a1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0166-4328(03)00074-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12946604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Glover, Dorie A</creatorcontrib><creatorcontrib>Powers, Mark B</creatorcontrib><creatorcontrib>Bergman, Lyndsey</creatorcontrib><creatorcontrib>Smits, Jasper A.J</creatorcontrib><creatorcontrib>Telch, Michael J</creatorcontrib><creatorcontrib>Stuber, Margaret</creatorcontrib><title>Urinary dopamine and turn bias in traumatized women with and without PTSD symptoms</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>Turning biases are known to occur in the direction of the brain hemisphere with decreased dopamine (DA). Although elevations in urinary DA have been shown in posttraumatic stress disorder (PTSD), evidence for dysregulation of dopaminergic activity in the brain is lacking. Turn bias and urinary DA levels were examined in mothers of childhood cancer survivors. As expected, cancer trauma mothers with PTSD symptoms (
n=14) had higher urinary DA levels than trauma mothers without PTSD symptoms (
n=7) and controls (
n=8) (
P=0.01). Groups were also significantly different in prevalence of left turn bias (
P=0.03). All controls (100%) showed a left turn bias compared to 75 and 37.5% prevalence among trauma mothers with and without PTSD, respectively. Urinary DA levels and turn bias rates were not correlated. Results lend support for further exploration of DA in traumatized groups with and without PTSD.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Biomarkers</subject><subject>Chi-Square Distribution</subject><subject>Child</subject><subject>Dopamine</subject><subject>Dopamine - urine</subject><subject>Female</subject><subject>Humans</subject><subject>Lateralization</subject><subject>Mothers - psychology</subject><subject>Movement Disorders - metabolism</subject><subject>Movement Disorders - psychology</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - physiopathology</subject><subject>Posttraumatic stress disorder</subject><subject>Psychiatric Status Rating Scales</subject><subject>Stress Disorders, Post-Traumatic - psychology</subject><subject>Stress Disorders, Post-Traumatic - urine</subject><subject>Survivors</subject><subject>Trauma</subject><subject>Turn bias</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAQgIMo7vr4CUpOoodq0qRJexJZnyAounsOaTKLkW27Jqmiv97sAz3uZR7MNzPwIXREyTklVFy8piAyzvLylLAzQojkGdtCQ1rKPJMFr7bR8A8ZoL0Q3hPESUF30YDmFReC8CF6mXjXav-NbTfXjWsB69bi2PsW104H7Focve4bHd0PWPzVNdDiLxffltyi6PqIn8ev1zh8N_PYNeEA7Uz1LMDhOu-jye3NeHSfPT7dPYyuHjPDcxazvODGlJRwYzUnlmhelKQSglUgWcGptlLXssjptIba1pYCE1RMSVHaNEndPjpZ3Z377qOHEFXjgoHZTLfQ9UFJJkpWcr4RpGXFuZAygcUKNL4LwcNUzb1rkh1FiVpYV0vraqFUEaaW1hVLe8frB33dgP3fWmtOwOUKgOTj04FXwThoDVjnwURlO7fhxS_LiZGG</recordid><startdate>20030915</startdate><enddate>20030915</enddate><creator>Glover, Dorie A</creator><creator>Powers, Mark B</creator><creator>Bergman, Lyndsey</creator><creator>Smits, Jasper A.J</creator><creator>Telch, Michael J</creator><creator>Stuber, Margaret</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20030915</creationdate><title>Urinary dopamine and turn bias in traumatized women with and without PTSD symptoms</title><author>Glover, Dorie A ; Powers, Mark B ; Bergman, Lyndsey ; Smits, Jasper A.J ; Telch, Michael J ; Stuber, Margaret</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-254cc8104cda40d0a458096639e73541ad7ab7521fbebdbd1e3616f058dd7a1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Biomarkers</topic><topic>Chi-Square Distribution</topic><topic>Child</topic><topic>Dopamine</topic><topic>Dopamine - urine</topic><topic>Female</topic><topic>Humans</topic><topic>Lateralization</topic><topic>Mothers - psychology</topic><topic>Movement Disorders - metabolism</topic><topic>Movement Disorders - psychology</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - physiopathology</topic><topic>Posttraumatic stress disorder</topic><topic>Psychiatric Status Rating Scales</topic><topic>Stress Disorders, Post-Traumatic - psychology</topic><topic>Stress Disorders, Post-Traumatic - urine</topic><topic>Survivors</topic><topic>Trauma</topic><topic>Turn bias</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Glover, Dorie A</creatorcontrib><creatorcontrib>Powers, Mark B</creatorcontrib><creatorcontrib>Bergman, Lyndsey</creatorcontrib><creatorcontrib>Smits, Jasper A.J</creatorcontrib><creatorcontrib>Telch, Michael J</creatorcontrib><creatorcontrib>Stuber, Margaret</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Glover, Dorie A</au><au>Powers, Mark B</au><au>Bergman, Lyndsey</au><au>Smits, Jasper A.J</au><au>Telch, Michael J</au><au>Stuber, Margaret</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary dopamine and turn bias in traumatized women with and without PTSD symptoms</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2003-09-15</date><risdate>2003</risdate><volume>144</volume><issue>1</issue><spage>137</spage><epage>141</epage><pages>137-141</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><abstract>Turning biases are known to occur in the direction of the brain hemisphere with decreased dopamine (DA). Although elevations in urinary DA have been shown in posttraumatic stress disorder (PTSD), evidence for dysregulation of dopaminergic activity in the brain is lacking. Turn bias and urinary DA levels were examined in mothers of childhood cancer survivors. As expected, cancer trauma mothers with PTSD symptoms (
n=14) had higher urinary DA levels than trauma mothers without PTSD symptoms (
n=7) and controls (
n=8) (
P=0.01). Groups were also significantly different in prevalence of left turn bias (
P=0.03). All controls (100%) showed a left turn bias compared to 75 and 37.5% prevalence among trauma mothers with and without PTSD, respectively. Urinary DA levels and turn bias rates were not correlated. Results lend support for further exploration of DA in traumatized groups with and without PTSD.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>12946604</pmid><doi>10.1016/S0166-4328(03)00074-3</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Analysis of Variance Biomarkers Chi-Square Distribution Child Dopamine Dopamine - urine Female Humans Lateralization Mothers - psychology Movement Disorders - metabolism Movement Disorders - psychology Neoplasms - metabolism Neoplasms - physiopathology Posttraumatic stress disorder Psychiatric Status Rating Scales Stress Disorders, Post-Traumatic - psychology Stress Disorders, Post-Traumatic - urine Survivors Trauma Turn bias |
| title | Urinary dopamine and turn bias in traumatized women with and without PTSD symptoms |
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