Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B

Background/Aims: Lamivudine therapy in patients with chronic hepatitis B can induce the recovery of antiviral T cell responses. It is unknown whether the recovery of T cell responsiveness is long-lasting and persists throughout the treatment and whether the elevation of viremia which follows therapy...

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Veröffentlicht in:	Journal of hepatology 2003-10, Vol.39 (4), p.595-605
Hauptverfasser:	Boni, Carolina, Penna, Amalia, Bertoletti, Antonio, Lamonaca, Vincenzo, Rapti, Irene, Missale, Gabriele, Pilli, Massimo, Urbani, Simona, Cavalli, Albertina, Cerioni, Simona, Panebianco, Ruggero, Jenkins, Julian, Ferrari, Carlo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences CD4 cells CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD8 cells CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cell Division - drug effects Chronic hepatitis B Cytokine production Female Hepatitis B virus - immunology Hepatitis B, Chronic - drug therapy Human viral diseases Humans Infectious diseases Lamivudine Lamivudine - therapeutic use Male Medical sciences Mitogens - pharmacology Phytohemagglutinins - pharmacology Reverse Transcriptase Inhibitors - therapeutic use T cell cytotoxicity T-Lymphocytes - immunology T-Lymphocytes - pathology T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - pathology Tetanus Toxoid - pharmacology Time Factors Viral diseases Viral hepatitis Viral load
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