Effects of dietary vitamin E and selenium on the mixed-function oxygenase system of male and female chicks
1. 1. Selenium- and vitamin E-depleted chicks were fed diets containing 0 or 0.2 ppm supplemental Se and/or 0 or 100 IU/kg vitamin E for 12 days; phenobarbital or water was administered orally for the final 6 days. 2. 2. Hepatic microsomal MFO activities, cytochrome P450 levels and NADPH-cytochrome...
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| Veröffentlicht in: | Comparative biochemistry and physiology. C, Comparative pharmacology Comparative pharmacology, 1981, Vol.69 (2), p.331-335 |
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| container_issue | 2 |
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| container_title | Comparative biochemistry and physiology. C, Comparative pharmacology |
| container_volume | 69 |
| creator | Pilch, Susan M. Combs, Gerald F. |
| description | 1.
1. Selenium- and vitamin E-depleted chicks were fed diets containing 0 or 0.2 ppm supplemental Se and/or 0 or 100 IU/kg vitamin E for 12 days; phenobarbital or water was administered orally for the final 6 days.
2.
2. Hepatic microsomal MFO activities, cytochrome
P450 levels and NADPH-cytochrome
c reductase activities were not significantly affected by sex or diet in uninduced chicks.
3.
3. Maximal induction of MFO activity was impaired by combined Se/vitamin E deficiency in male, but not female, chicks.
4.
4. Induction of cytochrome
P450 and NADPH-cytochrome
c reductase was not significantly affected by diet in male or female chicks.
5.
5. Total glutathione peroxidase activity was increased by phenobarbital treatment; Se-dependent glutathione peroxidase activity was not affected. |
| doi_str_mv | 10.1016/0306-4492(81)90146-5 |
| format | Article |
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1. Selenium- and vitamin E-depleted chicks were fed diets containing 0 or 0.2 ppm supplemental Se and/or 0 or 100 IU/kg vitamin E for 12 days; phenobarbital or water was administered orally for the final 6 days.
2.
2. Hepatic microsomal MFO activities, cytochrome
P450 levels and NADPH-cytochrome
c reductase activities were not significantly affected by sex or diet in uninduced chicks.
3.
3. Maximal induction of MFO activity was impaired by combined Se/vitamin E deficiency in male, but not female, chicks.
4.
4. Induction of cytochrome
P450 and NADPH-cytochrome
c reductase was not significantly affected by diet in male or female chicks.
5.
5. Total glutathione peroxidase activity was increased by phenobarbital treatment; Se-dependent glutathione peroxidase activity was not affected.</description><identifier>ISSN: 0306-4492</identifier><identifier>DOI: 10.1016/0306-4492(81)90146-5</identifier><identifier>PMID: 6116572</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>animal nutrition ; Animals ; Body Weight - drug effects ; Chickens - metabolism ; Diet ; Enzyme Induction ; Female ; Glutathione Peroxidase - metabolism ; Male ; Mixed Function Oxygenases - metabolism ; Organ Size - drug effects ; Oxidoreductases - metabolism ; Phenobarbital - pharmacology ; Selenium - pharmacology ; Sex Factors ; Vitamin E - pharmacology</subject><ispartof>Comparative biochemistry and physiology. C, Comparative pharmacology, 1981, Vol.69 (2), p.331-335</ispartof><rights>1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-cb4aaeaae8e0e205ba20c04a10bf2fa84f0fa7aa93cafcefa90112fbb3c2473c3</citedby><cites>FETCH-LOGICAL-c447t-cb4aaeaae8e0e205ba20c04a10bf2fa84f0fa7aa93cafcefa90112fbb3c2473c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6116572$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pilch, Susan M.</creatorcontrib><creatorcontrib>Combs, Gerald F.</creatorcontrib><title>Effects of dietary vitamin E and selenium on the mixed-function oxygenase system of male and female chicks</title><title>Comparative biochemistry and physiology. C, Comparative pharmacology</title><addtitle>Comp Biochem Physiol C</addtitle><description>1.
1. Selenium- and vitamin E-depleted chicks were fed diets containing 0 or 0.2 ppm supplemental Se and/or 0 or 100 IU/kg vitamin E for 12 days; phenobarbital or water was administered orally for the final 6 days.
2.
2. Hepatic microsomal MFO activities, cytochrome
P450 levels and NADPH-cytochrome
c reductase activities were not significantly affected by sex or diet in uninduced chicks.
3.
3. Maximal induction of MFO activity was impaired by combined Se/vitamin E deficiency in male, but not female, chicks.
4.
4. Induction of cytochrome
P450 and NADPH-cytochrome
c reductase was not significantly affected by diet in male or female chicks.
5.
5. Total glutathione peroxidase activity was increased by phenobarbital treatment; Se-dependent glutathione peroxidase activity was not affected.</description><subject>animal nutrition</subject><subject>Animals</subject><subject>Body Weight - drug effects</subject><subject>Chickens - metabolism</subject><subject>Diet</subject><subject>Enzyme Induction</subject><subject>Female</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Male</subject><subject>Mixed Function Oxygenases - metabolism</subject><subject>Organ Size - drug effects</subject><subject>Oxidoreductases - metabolism</subject><subject>Phenobarbital - pharmacology</subject><subject>Selenium - pharmacology</subject><subject>Sex Factors</subject><subject>Vitamin E - pharmacology</subject><issn>0306-4492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUlPwzAQhX0AQVn-AQifEBwC3prlgoRQWaRKHKBna-KMiyFLiZOq_fc4bdUj1ki2Zt57sj8TcsHZHWc8vmeSxZFSmbhJ-W3GuIqj8QEZ7dvH5MT7b8Z4lsr0iBzFnMfjRIzI98RaNJ2njaWFww7aNV26DipX0wmFuqAeS6xdX9Gmpt0X0sqtsIhsX5vOhVazWs-xBo_Ur32H1RBUQYkbr8XN0Xw58-PPyKGF0uP5bj8ls-fJ59NrNH1_eXt6nEZGqaSLTK4AMFSKDAUb5yCYYQo4y62wkCrLLCQAmTRgDVoIz-XC5rk0QiXSyFNyvc1dtM1vj77TlfMGyxJqbHqvExkPSwSh2gpN23jfotWL1lWBgOZMD1j1wE8P_HTK9QarHgfb5S6_zyss9qYd0zC_2s4tNBrmrfN69iEYl6F4JpUMioetAgOGpcNWe-OwNli4NnyGLhr3_xX-AMBSlFA</recordid><startdate>1981</startdate><enddate>1981</enddate><creator>Pilch, Susan M.</creator><creator>Combs, Gerald F.</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1981</creationdate><title>Effects of dietary vitamin E and selenium on the mixed-function oxygenase system of male and female chicks</title><author>Pilch, Susan M. ; Combs, Gerald F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-cb4aaeaae8e0e205ba20c04a10bf2fa84f0fa7aa93cafcefa90112fbb3c2473c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>animal nutrition</topic><topic>Animals</topic><topic>Body Weight - drug effects</topic><topic>Chickens - metabolism</topic><topic>Diet</topic><topic>Enzyme Induction</topic><topic>Female</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Male</topic><topic>Mixed Function Oxygenases - metabolism</topic><topic>Organ Size - drug effects</topic><topic>Oxidoreductases - metabolism</topic><topic>Phenobarbital - pharmacology</topic><topic>Selenium - pharmacology</topic><topic>Sex Factors</topic><topic>Vitamin E - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pilch, Susan M.</creatorcontrib><creatorcontrib>Combs, Gerald F.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Comparative biochemistry and physiology. C, Comparative pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pilch, Susan M.</au><au>Combs, Gerald F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of dietary vitamin E and selenium on the mixed-function oxygenase system of male and female chicks</atitle><jtitle>Comparative biochemistry and physiology. C, Comparative pharmacology</jtitle><addtitle>Comp Biochem Physiol C</addtitle><date>1981</date><risdate>1981</risdate><volume>69</volume><issue>2</issue><spage>331</spage><epage>335</epage><pages>331-335</pages><issn>0306-4492</issn><abstract>1.
1. Selenium- and vitamin E-depleted chicks were fed diets containing 0 or 0.2 ppm supplemental Se and/or 0 or 100 IU/kg vitamin E for 12 days; phenobarbital or water was administered orally for the final 6 days.
2.
2. Hepatic microsomal MFO activities, cytochrome
P450 levels and NADPH-cytochrome
c reductase activities were not significantly affected by sex or diet in uninduced chicks.
3.
3. Maximal induction of MFO activity was impaired by combined Se/vitamin E deficiency in male, but not female, chicks.
4.
4. Induction of cytochrome
P450 and NADPH-cytochrome
c reductase was not significantly affected by diet in male or female chicks.
5.
5. Total glutathione peroxidase activity was increased by phenobarbital treatment; Se-dependent glutathione peroxidase activity was not affected.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>6116572</pmid><doi>10.1016/0306-4492(81)90146-5</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-4492 |
| ispartof | Comparative biochemistry and physiology. C, Comparative pharmacology, 1981, Vol.69 (2), p.331-335 |
| issn | 0306-4492 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73666662 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | animal nutrition Animals Body Weight - drug effects Chickens - metabolism Diet Enzyme Induction Female Glutathione Peroxidase - metabolism Male Mixed Function Oxygenases - metabolism Organ Size - drug effects Oxidoreductases - metabolism Phenobarbital - pharmacology Selenium - pharmacology Sex Factors Vitamin E - pharmacology |
| title | Effects of dietary vitamin E and selenium on the mixed-function oxygenase system of male and female chicks |
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