Renin-angiotensin system gene polymorphisms: assessment of the risk of coronary heart disease
Renin-angiotensin system genes are candidate genes in cardiovascular system diseases. Angiotensinconverting enzyme (ACE), angiotensinogen (AGT) and angiotensin II type 1 receptor (AT1R) gene polymorphisms are considered risk factors in coronary heart disease (CHD). To evaluate the involvement of the...
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| Veröffentlicht in: | Kardiologia polska (1957) 2003-01, Vol.58 (1), p.1-9 |
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| container_title | Kardiologia polska (1957) |
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| creator | Buraczyńska, Monika Pijanowski, Zbigniew Spasiewicz, Danuta Nowicka, Teresa Sodolski, Tomasz Widomska - Czekajska, Teresa Ksiazek, Andrzej |
| description | Renin-angiotensin system genes are candidate genes in cardiovascular system diseases. Angiotensinconverting enzyme (ACE), angiotensinogen (AGT) and angiotensin II type 1 receptor (AT1R) gene polymorphisms are considered risk factors in coronary heart disease (CHD).
To evaluate the involvement of the ACE, AGT and AT1R genetic variants in predisposition to CHD as well as their association with other known risk factors.
The study included 400 male subjects (200 with CHD and 200 healthy individuals). Genotypes were determined by a polymerase chain reaction (PCR). For the AGT and AT1R genes a restriction analysis of the PCR product was performed. The allele frequency and genotype distribution were compared between groups.
The allele and genotype frequencies of the ACE gene were similar in both groups, however, a significantly higher frequency of the DD genotype was observed in the presence of hyperlipidemia (39% vs 24% in non-hyperlipidemic subjects, p |
| format | Article |
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To evaluate the involvement of the ACE, AGT and AT1R genetic variants in predisposition to CHD as well as their association with other known risk factors.
The study included 400 male subjects (200 with CHD and 200 healthy individuals). Genotypes were determined by a polymerase chain reaction (PCR). For the AGT and AT1R genes a restriction analysis of the PCR product was performed. The allele frequency and genotype distribution were compared between groups.
The allele and genotype frequencies of the ACE gene were similar in both groups, however, a significantly higher frequency of the DD genotype was observed in the presence of hyperlipidemia (39% vs 24% in non-hyperlipidemic subjects, p<0.01). The AGT gene polymorphism was associated with the development of CHD. The T allele was significantly more frequent in patients than in the control group (55% vs 44%, p<0.05). The heterozygous MT genotype was observed in 61% of patients compared to 40% in the controls (p<0.05). The A1166C polymorphism of the AT1R gene was also associated with CHD as well as with age at the onset of disease. The frequency of the C allele was 29% compared to 21% in the control group (p<0.01) and the frequency of the CC homozygote was almost three times higher in patients.
There is an association between molecular variants of the angiotensinogen and angiotensin II type 1 receptor and increased risk of CHD. The DD genotype of the ACE gene polymorphism and the TT genotype of the AGT gene polymorphism were significantly more frequent in patients with hyperlipidemia. The TT genotype of the AGT gene M235T polymorphism was associated with an increased risk of CHD and myocardial infarction only in smokers.</description><identifier>ISSN: 0022-9032</identifier><identifier>PMID: 14502296</identifier><language>eng</language><publisher>Poland</publisher><subject>Adult ; Aged ; Angiotensinogen - genetics ; Coronary Disease - genetics ; Gene Frequency ; Genotype ; Humans ; Male ; Middle Aged ; Peptidyl-Dipeptidase A - genetics ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Receptor, Angiotensin, Type 1 ; Receptors, Angiotensin - genetics ; Renin-Angiotensin System - genetics ; Risk Assessment ; Risk Factors</subject><ispartof>Kardiologia polska (1957), 2003-01, Vol.58 (1), p.1-9</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14502296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buraczyńska, Monika</creatorcontrib><creatorcontrib>Pijanowski, Zbigniew</creatorcontrib><creatorcontrib>Spasiewicz, Danuta</creatorcontrib><creatorcontrib>Nowicka, Teresa</creatorcontrib><creatorcontrib>Sodolski, Tomasz</creatorcontrib><creatorcontrib>Widomska - Czekajska, Teresa</creatorcontrib><creatorcontrib>Ksiazek, Andrzej</creatorcontrib><title>Renin-angiotensin system gene polymorphisms: assessment of the risk of coronary heart disease</title><title>Kardiologia polska (1957)</title><addtitle>Kardiol Pol</addtitle><description>Renin-angiotensin system genes are candidate genes in cardiovascular system diseases. Angiotensinconverting enzyme (ACE), angiotensinogen (AGT) and angiotensin II type 1 receptor (AT1R) gene polymorphisms are considered risk factors in coronary heart disease (CHD).
To evaluate the involvement of the ACE, AGT and AT1R genetic variants in predisposition to CHD as well as their association with other known risk factors.
The study included 400 male subjects (200 with CHD and 200 healthy individuals). Genotypes were determined by a polymerase chain reaction (PCR). For the AGT and AT1R genes a restriction analysis of the PCR product was performed. The allele frequency and genotype distribution were compared between groups.
The allele and genotype frequencies of the ACE gene were similar in both groups, however, a significantly higher frequency of the DD genotype was observed in the presence of hyperlipidemia (39% vs 24% in non-hyperlipidemic subjects, p<0.01). The AGT gene polymorphism was associated with the development of CHD. The T allele was significantly more frequent in patients than in the control group (55% vs 44%, p<0.05). The heterozygous MT genotype was observed in 61% of patients compared to 40% in the controls (p<0.05). The A1166C polymorphism of the AT1R gene was also associated with CHD as well as with age at the onset of disease. The frequency of the C allele was 29% compared to 21% in the control group (p<0.01) and the frequency of the CC homozygote was almost three times higher in patients.
There is an association between molecular variants of the angiotensinogen and angiotensin II type 1 receptor and increased risk of CHD. The DD genotype of the ACE gene polymorphism and the TT genotype of the AGT gene polymorphism were significantly more frequent in patients with hyperlipidemia. The TT genotype of the AGT gene M235T polymorphism was associated with an increased risk of CHD and myocardial infarction only in smokers.</description><subject>Adult</subject><subject>Aged</subject><subject>Angiotensinogen - genetics</subject><subject>Coronary Disease - genetics</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Receptor, Angiotensin, Type 1</subject><subject>Receptors, Angiotensin - genetics</subject><subject>Renin-Angiotensin System - genetics</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><issn>0022-9032</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UEtLxDAYzEFx19W_IDl5K-TRpK03WXwsLAiiRylp-3UbbZKaLz3sv7fiepoZZhiGOSNrxoTIKibFilwifi6y1JxfkBXP1WJVek0-XsFbnxl_sCGBR-spHjGBowfwQKcwHl2I02DR4R01iIDowCcaepoGoNHi1y9vQwzexCMdwMREO4tgEK7IeW9GhOsTbsj748Pb9jnbvzzttvf7bOJCpKxkkGtZ9LlmRcF0wzlvAYreyFIw2UkOIJq87FSX51AyBU1bVU0BqlFSt6KUG3L71zvF8D0DptpZbGEcjYcwY11IrbVSYgnenIJz46Crp2jdsrr-P0T-ALQ-XLo</recordid><startdate>200301</startdate><enddate>200301</enddate><creator>Buraczyńska, Monika</creator><creator>Pijanowski, Zbigniew</creator><creator>Spasiewicz, Danuta</creator><creator>Nowicka, Teresa</creator><creator>Sodolski, Tomasz</creator><creator>Widomska - Czekajska, Teresa</creator><creator>Ksiazek, Andrzej</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200301</creationdate><title>Renin-angiotensin system gene polymorphisms: assessment of the risk of coronary heart disease</title><author>Buraczyńska, Monika ; Pijanowski, Zbigniew ; Spasiewicz, Danuta ; Nowicka, Teresa ; Sodolski, Tomasz ; Widomska - Czekajska, Teresa ; Ksiazek, Andrzej</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p122t-80e4637f4607706b111cee7fa38203d31ee2b48d5d44e805ebc99b7e5b536c283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Angiotensinogen - genetics</topic><topic>Coronary Disease - genetics</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Receptor, Angiotensin, Type 1</topic><topic>Receptors, Angiotensin - genetics</topic><topic>Renin-Angiotensin System - genetics</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buraczyńska, Monika</creatorcontrib><creatorcontrib>Pijanowski, Zbigniew</creatorcontrib><creatorcontrib>Spasiewicz, Danuta</creatorcontrib><creatorcontrib>Nowicka, Teresa</creatorcontrib><creatorcontrib>Sodolski, Tomasz</creatorcontrib><creatorcontrib>Widomska - Czekajska, Teresa</creatorcontrib><creatorcontrib>Ksiazek, Andrzej</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Kardiologia polska (1957)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buraczyńska, Monika</au><au>Pijanowski, Zbigniew</au><au>Spasiewicz, Danuta</au><au>Nowicka, Teresa</au><au>Sodolski, Tomasz</au><au>Widomska - Czekajska, Teresa</au><au>Ksiazek, Andrzej</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renin-angiotensin system gene polymorphisms: assessment of the risk of coronary heart disease</atitle><jtitle>Kardiologia polska (1957)</jtitle><addtitle>Kardiol Pol</addtitle><date>2003-01</date><risdate>2003</risdate><volume>58</volume><issue>1</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>0022-9032</issn><abstract>Renin-angiotensin system genes are candidate genes in cardiovascular system diseases. Angiotensinconverting enzyme (ACE), angiotensinogen (AGT) and angiotensin II type 1 receptor (AT1R) gene polymorphisms are considered risk factors in coronary heart disease (CHD).
To evaluate the involvement of the ACE, AGT and AT1R genetic variants in predisposition to CHD as well as their association with other known risk factors.
The study included 400 male subjects (200 with CHD and 200 healthy individuals). Genotypes were determined by a polymerase chain reaction (PCR). For the AGT and AT1R genes a restriction analysis of the PCR product was performed. The allele frequency and genotype distribution were compared between groups.
The allele and genotype frequencies of the ACE gene were similar in both groups, however, a significantly higher frequency of the DD genotype was observed in the presence of hyperlipidemia (39% vs 24% in non-hyperlipidemic subjects, p<0.01). The AGT gene polymorphism was associated with the development of CHD. The T allele was significantly more frequent in patients than in the control group (55% vs 44%, p<0.05). The heterozygous MT genotype was observed in 61% of patients compared to 40% in the controls (p<0.05). The A1166C polymorphism of the AT1R gene was also associated with CHD as well as with age at the onset of disease. The frequency of the C allele was 29% compared to 21% in the control group (p<0.01) and the frequency of the CC homozygote was almost three times higher in patients.
There is an association between molecular variants of the angiotensinogen and angiotensin II type 1 receptor and increased risk of CHD. The DD genotype of the ACE gene polymorphism and the TT genotype of the AGT gene polymorphism were significantly more frequent in patients with hyperlipidemia. The TT genotype of the AGT gene M235T polymorphism was associated with an increased risk of CHD and myocardial infarction only in smokers.</abstract><cop>Poland</cop><pmid>14502296</pmid><tpages>9</tpages></addata></record> |
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| ispartof | Kardiologia polska (1957), 2003-01, Vol.58 (1), p.1-9 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Angiotensinogen - genetics Coronary Disease - genetics Gene Frequency Genotype Humans Male Middle Aged Peptidyl-Dipeptidase A - genetics Polymerase Chain Reaction Polymorphism, Genetic Receptor, Angiotensin, Type 1 Receptors, Angiotensin - genetics Renin-Angiotensin System - genetics Risk Assessment Risk Factors |
| title | Renin-angiotensin system gene polymorphisms: assessment of the risk of coronary heart disease |
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