Absence of stainable bone marrow iron in hemochromatosis

Stainable bone marrow iron was absent from two patients who were found at autopsy to have hemochromatosis. Bleeding could have accounted for the absence of marrow iron in one patient, but there was no evidence of blood loss in the other. Both had cirrhosis and heavy iron deposits in the liver parenc...

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Veröffentlicht in:	Southern medical journal (Birmingham, Ala.) Ala.), 1981-09, Vol.74 (9), p.1088-1089
Hauptverfasser:	Herring, W B, Gay, R M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Bone Marrow - metabolism Female Hemochromatosis - diagnosis Hemochromatosis - metabolism Humans Iron - metabolism Male Middle Aged Staining and Labeling
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description	Stainable bone marrow iron was absent from two patients who were found at autopsy to have hemochromatosis. Bleeding could have accounted for the absence of marrow iron in one patient, but there was no evidence of blood loss in the other. Both had cirrhosis and heavy iron deposits in the liver parenchyma. It is suggested that in patients with hemochromatosis and hepatic cirrhosis, absorbed dietary iron is ultimately taken up by the liver at the expense of the erythron, resulting in gradual depletion of marrow stores. A postulated mechanism is that the shunting of portal blood around the liver circumvents some iron-liver interaction that directs absorbed dietary iron to the erythron.
doi_str_mv	10.1097/00007611-198109000-00019
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Bleeding could have accounted for the absence of marrow iron in one patient, but there was no evidence of blood loss in the other. Both had cirrhosis and heavy iron deposits in the liver parenchyma. It is suggested that in patients with hemochromatosis and hepatic cirrhosis, absorbed dietary iron is ultimately taken up by the liver at the expense of the erythron, resulting in gradual depletion of marrow stores. A postulated mechanism is that the shunting of portal blood around the liver circumvents some iron-liver interaction that directs absorbed dietary iron to the erythron.</description><identifier>ISSN: 0038-4348</identifier><identifier>DOI: 10.1097/00007611-198109000-00019</identifier><identifier>PMID: 6169159</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Bone Marrow - metabolism ; Female ; Hemochromatosis - diagnosis ; Hemochromatosis - metabolism ; Humans ; Iron - metabolism ; Male ; Middle Aged ; Staining and Labeling</subject><ispartof>Southern medical journal (Birmingham, Ala.), 1981-09, Vol.74 (9), p.1088-1089</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c310t-d6a824c98b4ed91f0a96a9568f4e9023954f81c55c5b68a78a5fb0714714fa7a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6169159$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Herring, W B</creatorcontrib><creatorcontrib>Gay, R M</creatorcontrib><title>Absence of stainable bone marrow iron in hemochromatosis</title><title>Southern medical journal (Birmingham, Ala.)</title><addtitle>South Med J</addtitle><description>Stainable bone marrow iron was absent from two patients who were found at autopsy to have hemochromatosis. Bleeding could have accounted for the absence of marrow iron in one patient, but there was no evidence of blood loss in the other. Both had cirrhosis and heavy iron deposits in the liver parenchyma. It is suggested that in patients with hemochromatosis and hepatic cirrhosis, absorbed dietary iron is ultimately taken up by the liver at the expense of the erythron, resulting in gradual depletion of marrow stores. A postulated mechanism is that the shunting of portal blood around the liver circumvents some iron-liver interaction that directs absorbed dietary iron to the erythron.</description><subject>Aged</subject><subject>Bone Marrow - metabolism</subject><subject>Female</subject><subject>Hemochromatosis - diagnosis</subject><subject>Hemochromatosis - metabolism</subject><subject>Humans</subject><subject>Iron - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Staining and Labeling</subject><issn>0038-4348</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1PwzAMhnMAjTH4CUg5cSvEy0eT4zQBQ5rEBc5RkiZaUduMpBXi35OxMcuWZeu1LT8IYSAPQFT9SIrVAqACJUujVFUJUBdoTgiVFaNMXqHrnD8PQi7FDM0ECAVczZFc2ewH53EMOI-mHYztPLZx8Lg3KcVv3KY44HbAO99Ht0uxN2PMbb5Bl8F02d-e8gJ9PD-9rzfV9u3ldb3aVo4CGatGGLlkTknLfKMgEKOEUVzIwLwiS6o4CxIc545bIU0tDQ-W1MCKB1MbukD3x737FL8mn0fdt9n5rjODj1PWNRWCM66KUB6FLsWckw96n9ryw48Gog-g9D8ofQal_0CV0bvTjcn2vjkPnijRX35nZKA</recordid><startdate>198109</startdate><enddate>198109</enddate><creator>Herring, W B</creator><creator>Gay, R M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198109</creationdate><title>Absence of stainable bone marrow iron in hemochromatosis</title><author>Herring, W B ; Gay, R M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c310t-d6a824c98b4ed91f0a96a9568f4e9023954f81c55c5b68a78a5fb0714714fa7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Aged</topic><topic>Bone Marrow - metabolism</topic><topic>Female</topic><topic>Hemochromatosis - diagnosis</topic><topic>Hemochromatosis - metabolism</topic><topic>Humans</topic><topic>Iron - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Staining and Labeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herring, W B</creatorcontrib><creatorcontrib>Gay, R M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Southern medical journal (Birmingham, Ala.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herring, W B</au><au>Gay, R M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Absence of stainable bone marrow iron in hemochromatosis</atitle><jtitle>Southern medical journal (Birmingham, Ala.)</jtitle><addtitle>South Med J</addtitle><date>1981-09</date><risdate>1981</risdate><volume>74</volume><issue>9</issue><spage>1088</spage><epage>1089</epage><pages>1088-1089</pages><issn>0038-4348</issn><abstract>Stainable bone marrow iron was absent from two patients who were found at autopsy to have hemochromatosis. Bleeding could have accounted for the absence of marrow iron in one patient, but there was no evidence of blood loss in the other. Both had cirrhosis and heavy iron deposits in the liver parenchyma. It is suggested that in patients with hemochromatosis and hepatic cirrhosis, absorbed dietary iron is ultimately taken up by the liver at the expense of the erythron, resulting in gradual depletion of marrow stores. A postulated mechanism is that the shunting of portal blood around the liver circumvents some iron-liver interaction that directs absorbed dietary iron to the erythron.</abstract><cop>United States</cop><pmid>6169159</pmid><doi>10.1097/00007611-198109000-00019</doi><tpages>2</tpages></addata></record>
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identifier	ISSN: 0038-4348
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source	MEDLINE; Journals@Ovid Complete
subjects	Aged Bone Marrow - metabolism Female Hemochromatosis - diagnosis Hemochromatosis - metabolism Humans Iron - metabolism Male Middle Aged Staining and Labeling
title	Absence of stainable bone marrow iron in hemochromatosis
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