Cationic Tc-99m Complexes as Potential Myocardial Imaging Agents
Nineteen cationic Tc-99m complexes, based upon four different ligand series, have been synthesized under "no carrier added" conditions and qualitatively evaluated as myocardial imaging agents in a dog model. Of these complexes, the four halogen derivatives of the diars series [diars = o-ph...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1981-10, Vol.22 (10), p.897-907 |
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| container_title | The Journal of nuclear medicine (1978) |
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| creator | Deutsch, Edward Glavan, Kenneth A Sodd, Vincent J Nishiyama, Hiroshi Ferguson, Debra L Lukes, Steven J |
| description | Nineteen cationic Tc-99m complexes, based upon four different ligand series, have been synthesized under "no carrier added" conditions and qualitatively evaluated as myocardial imaging agents in a dog model. Of these complexes, the four halogen derivatives of the diars series [diars = o-phenylenebis(dimethylarsine)] successfully concentrate in the myocardium. These Tc-99m diars complexes are shown by thin-layer chromatography to be identical to the Tc-99 analogs that have been fully characterized as trans octahedral complexes of Tc(III) by classical chemical techniques. Tissue distribution studies in rats show a definite difference in the biodistributions of [99mTc(diars)2Cl2]+ and [99mTc(diars)2Br2]+, despite the similar size, shape, charge, and lipophilicity of these two complexes. A tissue distribution study in resting beagle dogs shows that [99mTc(diars)2Br2]+ accumulates in the normal myocardium about half as well as TI-201 (0.022 compared with 0.038% dose/g). |
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Of these complexes, the four halogen derivatives of the diars series [diars = o-phenylenebis(dimethylarsine)] successfully concentrate in the myocardium. These Tc-99m diars complexes are shown by thin-layer chromatography to be identical to the Tc-99 analogs that have been fully characterized as trans octahedral complexes of Tc(III) by classical chemical techniques. Tissue distribution studies in rats show a definite difference in the biodistributions of [99mTc(diars)2Cl2]+ and [99mTc(diars)2Br2]+, despite the similar size, shape, charge, and lipophilicity of these two complexes. A tissue distribution study in resting beagle dogs shows that [99mTc(diars)2Br2]+ accumulates in the normal myocardium about half as well as TI-201 (0.022 compared with 0.038% dose/g).</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 7288486</identifier><language>eng</language><publisher>United States: Soc Nuclear Med</publisher><subject>Animals ; Dogs ; Female ; Heart - diagnostic imaging ; Male ; Myocardium - metabolism ; Radionuclide Imaging ; Rats ; Rats, Inbred Strains ; Technetium - metabolism ; Time Factors ; Tissue Distribution</subject><ispartof>The Journal of nuclear medicine (1978), 1981-10, Vol.22 (10), p.897-907</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7288486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deutsch, Edward</creatorcontrib><creatorcontrib>Glavan, Kenneth A</creatorcontrib><creatorcontrib>Sodd, Vincent J</creatorcontrib><creatorcontrib>Nishiyama, Hiroshi</creatorcontrib><creatorcontrib>Ferguson, Debra L</creatorcontrib><creatorcontrib>Lukes, Steven J</creatorcontrib><title>Cationic Tc-99m Complexes as Potential Myocardial Imaging Agents</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>Nineteen cationic Tc-99m complexes, based upon four different ligand series, have been synthesized under "no carrier added" conditions and qualitatively evaluated as myocardial imaging agents in a dog model. Of these complexes, the four halogen derivatives of the diars series [diars = o-phenylenebis(dimethylarsine)] successfully concentrate in the myocardium. These Tc-99m diars complexes are shown by thin-layer chromatography to be identical to the Tc-99 analogs that have been fully characterized as trans octahedral complexes of Tc(III) by classical chemical techniques. Tissue distribution studies in rats show a definite difference in the biodistributions of [99mTc(diars)2Cl2]+ and [99mTc(diars)2Br2]+, despite the similar size, shape, charge, and lipophilicity of these two complexes. 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Of these complexes, the four halogen derivatives of the diars series [diars = o-phenylenebis(dimethylarsine)] successfully concentrate in the myocardium. These Tc-99m diars complexes are shown by thin-layer chromatography to be identical to the Tc-99 analogs that have been fully characterized as trans octahedral complexes of Tc(III) by classical chemical techniques. Tissue distribution studies in rats show a definite difference in the biodistributions of [99mTc(diars)2Cl2]+ and [99mTc(diars)2Br2]+, despite the similar size, shape, charge, and lipophilicity of these two complexes. A tissue distribution study in resting beagle dogs shows that [99mTc(diars)2Br2]+ accumulates in the normal myocardium about half as well as TI-201 (0.022 compared with 0.038% dose/g).</abstract><cop>United States</cop><pub>Soc Nuclear Med</pub><pmid>7288486</pmid><tpages>11</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Dogs Female Heart - diagnostic imaging Male Myocardium - metabolism Radionuclide Imaging Rats Rats, Inbred Strains Technetium - metabolism Time Factors Tissue Distribution |
| title | Cationic Tc-99m Complexes as Potential Myocardial Imaging Agents |
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