Physicochemical Properties of Sildenafil Citrate (Viagra) and Sildenafil Base

Sildenafil citrate (Viagra) [I] and sildenafil base [II] are easily and unequivocally characterized by a set of physicochemical methods that include X‐ray diffractometry, infrared spectroscopy, and thermal analysis. Monoclinic lattice constants: [I]: a = 26.98 Å; b = 11.95 Å; c = 16.68 Å; β = 106.97...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 2003-10, Vol.92 (10), p.2140-2143
Hauptverfasser:	Melnikov, Petr, Corbi, Pedro P., Cuin, Alexandre, Cavicchioli, Mauricio, Guimarães, Wellington R.
Format:	Artikel
Sprache:	eng
Schlagworte:	bioinorganic chemistry Biological and medical sciences Citric Acid - chemistry Drug Stability General pharmacology Heating Medical sciences Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Piperazines - chemistry Powders Purines sildenafil base Sildenafil Citrate Spectrophotometry, Infrared Structure-Activity Relationship Sulfones Thermodynamics Viagra X-Ray Diffraction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Sildenafil citrate (Viagra) [I] and sildenafil base [II] are easily and unequivocally characterized by a set of physicochemical methods that include X‐ray diffractometry, infrared spectroscopy, and thermal analysis. Monoclinic lattice constants: [I]: a = 26.98 Å; b = 11.95 Å; c = 16.68 Å; β = 106.97°. [II]: a = 8.66 Å; b = 34.27 Å; c = 8.93 Å; β = 96.63°. Both compounds decompose at 189.4°C [I] and 251.9°C [II]. Densities and refractive indices are given. © 2003 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 92:2140–2143, 2003
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.10469