Myocardial gene expression of inflammatory cytokines after heart transplantation in relation to the development of transplant coronary artery disease
Long-term success of cardiac transplantation is mainly limited by the development of transplant coronary artery disease (CAD); it is generally accepted that it is immune mediated, involving cytokines and growth factors. We show that development of transplant CAD is associated with a particular cytok...
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| Veröffentlicht in: | The American journal of cardiology 2003-09, Vol.92 (6), p.715-717 |
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| container_title | The American journal of cardiology |
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| creator | Ueland, Thor Sikkeland, Liv I Yndestad, Arne Eiken, Hans G Holm, Torbjørn Guevara, Cecilia Haug, Terje Endresen, Knut Frøland, Stig S Gullestad, Lars Andreassen, Arne K Geiran, Odd Simonsen, Svein Aukrust, Pål |
| description | Long-term success of cardiac transplantation is mainly limited by the development of transplant coronary artery disease (CAD); it is generally accepted that it is immune mediated, involving cytokines and growth factors. We show that development of transplant CAD is associated with a particular cytokine profile in myocardial biopsies characterized by a late (i.e., 1 year) increase in tumor necrosis factor-α and interferon-γ gene expression, which precede and potentially contribute to the development of allograft vasculopathy, further supporting a role for inflammation and the pathogenesis of transplant CAD in humans. |
| doi_str_mv | 10.1016/S0002-9149(03)00836-1 |
| format | Article |
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We show that development of transplant CAD is associated with a particular cytokine profile in myocardial biopsies characterized by a late (i.e., 1 year) increase in tumor necrosis factor-α and interferon-γ gene expression, which precede and potentially contribute to the development of allograft vasculopathy, further supporting a role for inflammation and the pathogenesis of transplant CAD in humans.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/S0002-9149(03)00836-1</identifier><identifier>PMID: 12972116</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Blood vessels ; Coronary Artery Disease - etiology ; Coronary Artery Disease - genetics ; Cytokines - genetics ; Disease ; Female ; Follow-Up Studies ; Gene Expression - genetics ; Heart ; Heart Transplantation - adverse effects ; Humans ; Interferon-gamma - genetics ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Myocardium - pathology ; Surgery (general aspects). 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| identifier | ISSN: 0002-9149 |
| ispartof | The American journal of cardiology, 2003-09, Vol.92 (6), p.715-717 |
| issn | 0002-9149 1879-1913 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Biological and medical sciences Blood vessels Coronary Artery Disease - etiology Coronary Artery Disease - genetics Cytokines - genetics Disease Female Follow-Up Studies Gene Expression - genetics Heart Heart Transplantation - adverse effects Humans Interferon-gamma - genetics Longitudinal Studies Male Medical sciences Middle Aged Myocardium - pathology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Time Factors Transplants & implants Tumor Necrosis Factor-alpha - genetics |
| title | Myocardial gene expression of inflammatory cytokines after heart transplantation in relation to the development of transplant coronary artery disease |
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