Effects of neonatal treatment with phytoestrogens, genistein and daidzein, on sex difference in female rat brain function: estrous cycle and lordosis
It is well known that neonatal exposure to estrogen induces masculinization or defeminization of the brain. In this study, the effects of neonatal treatment with two kinds of soybean isoflavone aglycone, genistein (GS) and daidzein (DZ), on the estrous cycle and lordosis behavior were investigated....
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creator | Kouki, Tom Kishitake, Miki Okamoto, Miho Oosuka, Izumi Takebe, Minoru Yamanouchi, Korehito |
description | It is well known that neonatal exposure to estrogen induces masculinization or defeminization of the brain. In this study, the effects of neonatal treatment with two kinds of soybean isoflavone aglycone, genistein (GS) and daidzein (DZ), on the estrous cycle and lordosis behavior were investigated. Female rats were injected subcutaneously with 1 mg GS, 1 mg DZ, 100 μg estradiol (E
2), or oil daily for 5 days from birth. As a result, vaginal opening was advanced in GS- or E
2-treated females. A vaginal smear check indicated that oil- or DZ-treated females showed a constant 4- or 5-day estrous cycle, whereas GS- or E
2-treated rats showed a persistent or prolonged estrus. Ovariectomy was performed in all females at 60 days of age. The ovaries in the GS- or E
2-treated groups were smaller than those in the oil- and DZ-treated groups and contained no corpora lutea. In the DZ group, although corpora lutea were seen, ovaries were smaller than that of control females. Behavioral tests were carried out after implantation of E
2-tubes. All of the oil- or DZ-treated females showed lordosis with a high lordosis quotient (LQ). On the other hand, as male rats, LQs were extremely low in the E
2-treated group, when compared to the oil-treated group. In the GS-treated group, the mean LQ was lower than that in the oil-treated group, but higher than those in the E
2-treated female or male groups. These results suggest that genistein acts as an estrogen in the sexual differentiation of the brain and causes defeminization of the brain in regulating lordosis and the estrous cycle in rats. In addition, neonatal daidzein also has some influence on ovarian function. |
doi_str_mv | 10.1016/S0018-506X(03)00122-3 |
format | Article |
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2), or oil daily for 5 days from birth. As a result, vaginal opening was advanced in GS- or E
2-treated females. A vaginal smear check indicated that oil- or DZ-treated females showed a constant 4- or 5-day estrous cycle, whereas GS- or E
2-treated rats showed a persistent or prolonged estrus. Ovariectomy was performed in all females at 60 days of age. The ovaries in the GS- or E
2-treated groups were smaller than those in the oil- and DZ-treated groups and contained no corpora lutea. In the DZ group, although corpora lutea were seen, ovaries were smaller than that of control females. Behavioral tests were carried out after implantation of E
2-tubes. All of the oil- or DZ-treated females showed lordosis with a high lordosis quotient (LQ). On the other hand, as male rats, LQs were extremely low in the E
2-treated group, when compared to the oil-treated group. In the GS-treated group, the mean LQ was lower than that in the oil-treated group, but higher than those in the E
2-treated female or male groups. These results suggest that genistein acts as an estrogen in the sexual differentiation of the brain and causes defeminization of the brain in regulating lordosis and the estrous cycle in rats. In addition, neonatal daidzein also has some influence on ovarian function.</description><identifier>ISSN: 0018-506X</identifier><identifier>EISSN: 1095-6867</identifier><identifier>DOI: 10.1016/S0018-506X(03)00122-3</identifier><identifier>PMID: 13129486</identifier><identifier>CODEN: HOBEAO</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Animals, Newborn ; Behavioral psychophysiology ; Biological and medical sciences ; Brain ; daidzein ; Estradiol - physiology ; Estrogens, Non-Steroidal - pharmacology ; Estrous cycle ; Estrous Cycle - drug effects ; Female ; Fundamental and applied biological sciences. Psychology ; Genistein ; Genistein - pharmacology ; Hormones and behavior ; Isoflavones - pharmacology ; Lordosis ; Ovary - drug effects ; Phytoestrogen ; Phytoestrogens ; Plant Preparations ; Plants ; Posture - physiology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rat ; Rats ; Rats, Wistar ; Sex Characteristics ; Sex Differentiation - drug effects ; Sexual Behavior, Animal - drug effects ; Sexual differentiation</subject><ispartof>Hormones and behavior, 2003-08, Vol.44 (2), p.140-145, Article 140</ispartof><rights>2003 Elsevier Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-c58fe571b449d69ae9f9c4db4e08316075d63a67f13759ea3597f067a10392053</citedby><cites>FETCH-LOGICAL-c474t-c58fe571b449d69ae9f9c4db4e08316075d63a67f13759ea3597f067a10392053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0018506X03001223$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15136278$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13129486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kouki, Tom</creatorcontrib><creatorcontrib>Kishitake, Miki</creatorcontrib><creatorcontrib>Okamoto, Miho</creatorcontrib><creatorcontrib>Oosuka, Izumi</creatorcontrib><creatorcontrib>Takebe, Minoru</creatorcontrib><creatorcontrib>Yamanouchi, Korehito</creatorcontrib><title>Effects of neonatal treatment with phytoestrogens, genistein and daidzein, on sex difference in female rat brain function: estrous cycle and lordosis</title><title>Hormones and behavior</title><addtitle>Horm Behav</addtitle><description>It is well known that neonatal exposure to estrogen induces masculinization or defeminization of the brain. In this study, the effects of neonatal treatment with two kinds of soybean isoflavone aglycone, genistein (GS) and daidzein (DZ), on the estrous cycle and lordosis behavior were investigated. Female rats were injected subcutaneously with 1 mg GS, 1 mg DZ, 100 μg estradiol (E
2), or oil daily for 5 days from birth. As a result, vaginal opening was advanced in GS- or E
2-treated females. A vaginal smear check indicated that oil- or DZ-treated females showed a constant 4- or 5-day estrous cycle, whereas GS- or E
2-treated rats showed a persistent or prolonged estrus. Ovariectomy was performed in all females at 60 days of age. The ovaries in the GS- or E
2-treated groups were smaller than those in the oil- and DZ-treated groups and contained no corpora lutea. In the DZ group, although corpora lutea were seen, ovaries were smaller than that of control females. Behavioral tests were carried out after implantation of E
2-tubes. All of the oil- or DZ-treated females showed lordosis with a high lordosis quotient (LQ). On the other hand, as male rats, LQs were extremely low in the E
2-treated group, when compared to the oil-treated group. In the GS-treated group, the mean LQ was lower than that in the oil-treated group, but higher than those in the E
2-treated female or male groups. These results suggest that genistein acts as an estrogen in the sexual differentiation of the brain and causes defeminization of the brain in regulating lordosis and the estrous cycle in rats. In addition, neonatal daidzein also has some influence on ovarian function.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>daidzein</subject><subject>Estradiol - physiology</subject><subject>Estrogens, Non-Steroidal - pharmacology</subject><subject>Estrous cycle</subject><subject>Estrous Cycle - drug effects</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genistein</subject><subject>Genistein - pharmacology</subject><subject>Hormones and behavior</subject><subject>Isoflavones - pharmacology</subject><subject>Lordosis</subject><subject>Ovary - drug effects</subject><subject>Phytoestrogen</subject><subject>Phytoestrogens</subject><subject>Plant Preparations</subject><subject>Plants</subject><subject>Posture - physiology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sex Characteristics</subject><subject>Sex Differentiation - drug effects</subject><subject>Sexual Behavior, Animal - drug effects</subject><subject>Sexual differentiation</subject><issn>0018-506X</issn><issn>1095-6867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt9uFCEUxidGY9fqI2i40WjSURgGGPSiMU39kzTxQk28IywcLGYWtsDYru_h-8rsrm30pjeQQ37n8PF9NM1jgl8STPirzxiToWWYf3uO6YtadF1L7zQLgiVr-cDF3WZxjRw0D3L-UUvC-v5-c0Ao6WQ_8EXz-9Q5MCWj6FCAGHTRIyoJdFlBKOjSl3O0Pt-UCLmk-B1CPkJ19bmAD0gHi6z29lctjlAMKMMVsr6OTBAMoIo4WOkRUNIFLZOeD6Zgio_hNdqOnDIyG1OJedYYk43Z54fNPafHDI_2-2Hz9d3pl5MP7dmn9x9P3p61phd9aQ0bHDBBln0vLZcapJOmt8se8EAJx4JZTjUXjlDBJGjKpHCYC00wlR1m9LB5tpu7TvFiqnrUymcD46irF1NWgnImaI9vBYkkfOgkqSDbgSbFnBM4tU5-pdNGEazm4NQ2ODWnojBV2-AUrX1P9hdMyxXYm659UhV4ugd0Nnp0SQfj8w3HCOWdGCr35j8Bxhc9G16q_eO1jPxXxtW_Mo533VBd_-khqWz8HKX1qX4TZaO_5SF_AA_Iyeo</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Kouki, Tom</creator><creator>Kishitake, Miki</creator><creator>Okamoto, Miho</creator><creator>Oosuka, Izumi</creator><creator>Takebe, Minoru</creator><creator>Yamanouchi, Korehito</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7X8</scope></search><sort><creationdate>20030801</creationdate><title>Effects of neonatal treatment with phytoestrogens, genistein and daidzein, on sex difference in female rat brain function: estrous cycle and lordosis</title><author>Kouki, Tom ; Kishitake, Miki ; Okamoto, Miho ; Oosuka, Izumi ; Takebe, Minoru ; Yamanouchi, Korehito</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-c58fe571b449d69ae9f9c4db4e08316075d63a67f13759ea3597f067a10392053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>daidzein</topic><topic>Estradiol - physiology</topic><topic>Estrogens, Non-Steroidal - pharmacology</topic><topic>Estrous cycle</topic><topic>Estrous Cycle - drug effects</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genistein</topic><topic>Genistein - pharmacology</topic><topic>Hormones and behavior</topic><topic>Isoflavones - pharmacology</topic><topic>Lordosis</topic><topic>Ovary - drug effects</topic><topic>Phytoestrogen</topic><topic>Phytoestrogens</topic><topic>Plant Preparations</topic><topic>Plants</topic><topic>Posture - physiology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sex Characteristics</topic><topic>Sex Differentiation - drug effects</topic><topic>Sexual Behavior, Animal - drug effects</topic><topic>Sexual differentiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kouki, Tom</creatorcontrib><creatorcontrib>Kishitake, Miki</creatorcontrib><creatorcontrib>Okamoto, Miho</creatorcontrib><creatorcontrib>Oosuka, Izumi</creatorcontrib><creatorcontrib>Takebe, Minoru</creatorcontrib><creatorcontrib>Yamanouchi, Korehito</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Hormones and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kouki, Tom</au><au>Kishitake, Miki</au><au>Okamoto, Miho</au><au>Oosuka, Izumi</au><au>Takebe, Minoru</au><au>Yamanouchi, Korehito</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of neonatal treatment with phytoestrogens, genistein and daidzein, on sex difference in female rat brain function: estrous cycle and lordosis</atitle><jtitle>Hormones and behavior</jtitle><addtitle>Horm Behav</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>44</volume><issue>2</issue><spage>140</spage><epage>145</epage><pages>140-145</pages><artnum>140</artnum><issn>0018-506X</issn><eissn>1095-6867</eissn><coden>HOBEAO</coden><abstract>It is well known that neonatal exposure to estrogen induces masculinization or defeminization of the brain. In this study, the effects of neonatal treatment with two kinds of soybean isoflavone aglycone, genistein (GS) and daidzein (DZ), on the estrous cycle and lordosis behavior were investigated. Female rats were injected subcutaneously with 1 mg GS, 1 mg DZ, 100 μg estradiol (E
2), or oil daily for 5 days from birth. As a result, vaginal opening was advanced in GS- or E
2-treated females. A vaginal smear check indicated that oil- or DZ-treated females showed a constant 4- or 5-day estrous cycle, whereas GS- or E
2-treated rats showed a persistent or prolonged estrus. Ovariectomy was performed in all females at 60 days of age. The ovaries in the GS- or E
2-treated groups were smaller than those in the oil- and DZ-treated groups and contained no corpora lutea. In the DZ group, although corpora lutea were seen, ovaries were smaller than that of control females. Behavioral tests were carried out after implantation of E
2-tubes. All of the oil- or DZ-treated females showed lordosis with a high lordosis quotient (LQ). On the other hand, as male rats, LQs were extremely low in the E
2-treated group, when compared to the oil-treated group. In the GS-treated group, the mean LQ was lower than that in the oil-treated group, but higher than those in the E
2-treated female or male groups. These results suggest that genistein acts as an estrogen in the sexual differentiation of the brain and causes defeminization of the brain in regulating lordosis and the estrous cycle in rats. In addition, neonatal daidzein also has some influence on ovarian function.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>13129486</pmid><doi>10.1016/S0018-506X(03)00122-3</doi><tpages>6</tpages></addata></record> |
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subjects | Animals Animals, Newborn Behavioral psychophysiology Biological and medical sciences Brain daidzein Estradiol - physiology Estrogens, Non-Steroidal - pharmacology Estrous cycle Estrous Cycle - drug effects Female Fundamental and applied biological sciences. Psychology Genistein Genistein - pharmacology Hormones and behavior Isoflavones - pharmacology Lordosis Ovary - drug effects Phytoestrogen Phytoestrogens Plant Preparations Plants Posture - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rat Rats Rats, Wistar Sex Characteristics Sex Differentiation - drug effects Sexual Behavior, Animal - drug effects Sexual differentiation |
title | Effects of neonatal treatment with phytoestrogens, genistein and daidzein, on sex difference in female rat brain function: estrous cycle and lordosis |
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