Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects
The aim of the present study was to compare the response of a range of atherogenic and thrombogenic risk markers to two dietary levels of saturated fatty acid (SFA) substitution with monounsaturated fatty acids (MUFA) in students living in a university hall of residence. Although the benefits of suc...
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| Veröffentlicht in: | British journal of nutrition 2003-09, Vol.90 (3), p.597-606 |
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| creator | Smith, Ruth D. Kelly, Colette N. M. Fielding, Barbara A. Hauton, David Silva, K. D. Renuka R. Nydahl, Margaretha C. Miller, George J. Williams, Christine M. |
| description | The aim of the present study was to compare the response of a range of atherogenic and thrombogenic risk markers to two dietary levels of saturated fatty acid (SFA) substitution with monounsaturated fatty acids (MUFA) in students living in a university hall of residence. Although the benefits of such diets have been reported for plasma lipoproteins in high-risk groups, more needs to be known about effects of more modest SFA-MUFA substitutions over the long term and in young healthy adults. In a parallel design over 16 weeks, fifty-one healthy young subjects were randomised to one of two diets: (1) a moderate-MUFA diet in which 16 g dietary SFA/100 g total fatty acids were substituted with MUFA (n 25); (2) a high-MUFA diet in which 33 g dietary SFA/100 g total fatty acids were substituted with MUFA (n 26). All subjects followed an 8-week run-in diet (reference diet), with a fatty acid composition close to the UK average values. There were no differences in plasma lipid responses between the two diets over 16 weeks of the study with similar reductions in total cholesterol (P |
| doi_str_mv | 10.1079/BJN2003953 |
| format | Article |
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M. ; Fielding, Barbara A. ; Hauton, David ; Silva, K. D. Renuka R. ; Nydahl, Margaretha C. ; Miller, George J. ; Williams, Christine M.</creator><creatorcontrib>Smith, Ruth D. ; Kelly, Colette N. M. ; Fielding, Barbara A. ; Hauton, David ; Silva, K. D. Renuka R. ; Nydahl, Margaretha C. ; Miller, George J. ; Williams, Christine M.</creatorcontrib><description><![CDATA[The aim of the present study was to compare the response of a range of atherogenic and thrombogenic risk markers to two dietary levels of saturated fatty acid (SFA) substitution with monounsaturated fatty acids (MUFA) in students living in a university hall of residence. Although the benefits of such diets have been reported for plasma lipoproteins in high-risk groups, more needs to be known about effects of more modest SFA-MUFA substitutions over the long term and in young healthy adults. In a parallel design over 16 weeks, fifty-one healthy young subjects were randomised to one of two diets: (1) a moderate-MUFA diet in which 16 g dietary SFA/100 g total fatty acids were substituted with MUFA (n 25); (2) a high-MUFA diet in which 33 g dietary SFA/100 g total fatty acids were substituted with MUFA (n 26). All subjects followed an 8-week run-in diet (reference diet), with a fatty acid composition close to the UK average values. There were no differences in plasma lipid responses between the two diets over 16 weeks of the study with similar reductions in total cholesterol (P <0·001) and LDL-cholesterol (P<0·01) in both groups; a small but significant reduction in HDL-cholesterol was also observed in both groups (P<0·01). Platelet responses to ADP (P<0·01) and arachidonic acid (P<0·05) differed with time on the two diets; at 16 weeks, platelet aggregatory response to ADP was significantly lower on the high-MUFA than the moderate-MUFA (P<0·01) diet; ADP responses were also significantly lower within this group at 8 (P<0·05) and 16 (P<0·01) weeks compared with baseline. There were no differences in fasting factor VII activity (factors VIIc and VIIag), fibrinogen concentration or tissue-type plasminogen activator activity between the diets. There were no differences in postprandial factor VIIc responses to a standard meal (area under the curve) between the diets after 16 weeks, but postprandial factor VIIc response was lower than on the high-MUFA diet compared with baseline (P<0·01). In conclusion, a high-MUFA diet sustains potentially beneficial effects on platelet aggregation and postprandial activation of factor VII. Moderate or high substitution of MUFA for SFA achieves similar reductions in fasting blood lipids in young healthy subjects.]]></description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1079/BJN2003953</identifier><identifier>PMID: 13129466</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>adenosine diphosphate ; Adult ; adults ; Analysis of Variance ; arachidonic acid ; Area Under Curve ; Arteriosclerosis - blood ; Arteriosclerosis - prevention & control ; blood lipids ; Cholesterol ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Coagulation ; Diet ; Dietary Fats, Unsaturated - administration & dosage ; factor VII ; Factor VII - metabolism ; fasting ; fatty acid composition ; Fatty acids ; Fatty Acids, Monounsaturated - administration & dosage ; Female ; fibrinogen ; high density lipoprotein cholesterol ; Humans ; Lipids ; low density lipoprotein cholesterol ; Male ; monounsaturated fatty acids ; Monunsaturated fatty acids ; plasminogen activator ; Platelet Aggregation ; Postprandial Period ; risk ; Risk Factors ; saturated fatty acids ; Single-Blind Method ; students ; Thrombosis - blood ; Thrombosis - prevention & control</subject><ispartof>British journal of nutrition, 2003-09, Vol.90 (3), p.597-606</ispartof><rights>Copyright © The Nutrition Society 2003</rights><rights>The Nutrition Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-e2e9171cb636ee4fbf3515569c89ecf38545606d521a3d0eb65dc72164c161073</citedby><cites>FETCH-LOGICAL-c445t-e2e9171cb636ee4fbf3515569c89ecf38545606d521a3d0eb65dc72164c161073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13129466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, Ruth D.</creatorcontrib><creatorcontrib>Kelly, Colette N. M.</creatorcontrib><creatorcontrib>Fielding, Barbara A.</creatorcontrib><creatorcontrib>Hauton, David</creatorcontrib><creatorcontrib>Silva, K. D. Renuka R.</creatorcontrib><creatorcontrib>Nydahl, Margaretha C.</creatorcontrib><creatorcontrib>Miller, George J.</creatorcontrib><creatorcontrib>Williams, Christine M.</creatorcontrib><title>Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description><![CDATA[The aim of the present study was to compare the response of a range of atherogenic and thrombogenic risk markers to two dietary levels of saturated fatty acid (SFA) substitution with monounsaturated fatty acids (MUFA) in students living in a university hall of residence. Although the benefits of such diets have been reported for plasma lipoproteins in high-risk groups, more needs to be known about effects of more modest SFA-MUFA substitutions over the long term and in young healthy adults. In a parallel design over 16 weeks, fifty-one healthy young subjects were randomised to one of two diets: (1) a moderate-MUFA diet in which 16 g dietary SFA/100 g total fatty acids were substituted with MUFA (n 25); (2) a high-MUFA diet in which 33 g dietary SFA/100 g total fatty acids were substituted with MUFA (n 26). All subjects followed an 8-week run-in diet (reference diet), with a fatty acid composition close to the UK average values. There were no differences in plasma lipid responses between the two diets over 16 weeks of the study with similar reductions in total cholesterol (P <0·001) and LDL-cholesterol (P<0·01) in both groups; a small but significant reduction in HDL-cholesterol was also observed in both groups (P<0·01). Platelet responses to ADP (P<0·01) and arachidonic acid (P<0·05) differed with time on the two diets; at 16 weeks, platelet aggregatory response to ADP was significantly lower on the high-MUFA than the moderate-MUFA (P<0·01) diet; ADP responses were also significantly lower within this group at 8 (P<0·05) and 16 (P<0·01) weeks compared with baseline. There were no differences in fasting factor VII activity (factors VIIc and VIIag), fibrinogen concentration or tissue-type plasminogen activator activity between the diets. There were no differences in postprandial factor VIIc responses to a standard meal (area under the curve) between the diets after 16 weeks, but postprandial factor VIIc response was lower than on the high-MUFA diet compared with baseline (P<0·01). In conclusion, a high-MUFA diet sustains potentially beneficial effects on platelet aggregation and postprandial activation of factor VII. Moderate or high substitution of MUFA for SFA achieves similar reductions in fasting blood lipids in young healthy subjects.]]></description><subject>adenosine diphosphate</subject><subject>Adult</subject><subject>adults</subject><subject>Analysis of Variance</subject><subject>arachidonic acid</subject><subject>Area Under Curve</subject><subject>Arteriosclerosis - blood</subject><subject>Arteriosclerosis - prevention & control</subject><subject>blood lipids</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Coagulation</subject><subject>Diet</subject><subject>Dietary Fats, Unsaturated - administration & dosage</subject><subject>factor VII</subject><subject>Factor VII - metabolism</subject><subject>fasting</subject><subject>fatty acid composition</subject><subject>Fatty acids</subject><subject>Fatty Acids, Monounsaturated - administration & dosage</subject><subject>Female</subject><subject>fibrinogen</subject><subject>high density lipoprotein cholesterol</subject><subject>Humans</subject><subject>Lipids</subject><subject>low density lipoprotein cholesterol</subject><subject>Male</subject><subject>monounsaturated fatty acids</subject><subject>Monunsaturated fatty acids</subject><subject>plasminogen activator</subject><subject>Platelet Aggregation</subject><subject>Postprandial Period</subject><subject>risk</subject><subject>Risk Factors</subject><subject>saturated fatty acids</subject><subject>Single-Blind Method</subject><subject>students</subject><subject>Thrombosis - blood</subject><subject>Thrombosis - prevention & control</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0MuKFDEUBuAgitMzuvEBNLhwIZbmetK1HIfp9tIo4ozbmEqdqqm2Lm2SAvvtjXRjg7gIIZyPw5-fkCecvebMlG_efvgkGJOllvfIgiujCwEg7pMFY8wUnCt9Rs5j3ObnkrPyITnjkotSASzI9800tkXCMNBhGqd5jC7NwSWsaeNS2lPnu5rWHaZIA9azR7rr87jHRF3bBmxd6qaRdiO9Q9enuz3d5y0tjXO1RZ_iI_KgcX3Ex8f7gtyurm-u3hWbz-v3V5ebwiulU4ECS264r0AComqqRmquNZR-WaJv5FIrDQxqLbiTNcMKdO2N4KA8h9yCvCAvDnt3Yfo5Y0x26KLHvncjTnO0RoIGo1SGz_-B22kOY85mBZdLaRhARi8PyIcpxoCN3YVucGFvObN_Sren0jN-etw4VwPWJ3psOYPiALqY8NffuQs_LBhptIX1F7tac_i2-rixN9k_O_jGTda1oYv29qtgXLF8hClFFq-O-dxQha5u8fSL_yT8Dekjok4</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>Smith, Ruth D.</creator><creator>Kelly, Colette N. 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Renuka R.</creator><creator>Nydahl, Margaretha C.</creator><creator>Miller, George J.</creator><creator>Williams, Christine M.</creator><general>Cambridge University Press</general><general>CABI Pub</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20030901</creationdate><title>Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects</title><author>Smith, Ruth D. ; Kelly, Colette N. M. ; Fielding, Barbara A. ; Hauton, David ; Silva, K. D. Renuka R. ; Nydahl, Margaretha C. ; Miller, George J. ; Williams, Christine M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-e2e9171cb636ee4fbf3515569c89ecf38545606d521a3d0eb65dc72164c161073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>adenosine diphosphate</topic><topic>Adult</topic><topic>adults</topic><topic>Analysis of Variance</topic><topic>arachidonic acid</topic><topic>Area Under Curve</topic><topic>Arteriosclerosis - blood</topic><topic>Arteriosclerosis - prevention & control</topic><topic>blood lipids</topic><topic>Cholesterol</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Coagulation</topic><topic>Diet</topic><topic>Dietary Fats, Unsaturated - administration & dosage</topic><topic>factor VII</topic><topic>Factor VII - metabolism</topic><topic>fasting</topic><topic>fatty acid composition</topic><topic>Fatty acids</topic><topic>Fatty Acids, Monounsaturated - administration & dosage</topic><topic>Female</topic><topic>fibrinogen</topic><topic>high density lipoprotein cholesterol</topic><topic>Humans</topic><topic>Lipids</topic><topic>low density lipoprotein cholesterol</topic><topic>Male</topic><topic>monounsaturated fatty acids</topic><topic>Monunsaturated fatty acids</topic><topic>plasminogen activator</topic><topic>Platelet Aggregation</topic><topic>Postprandial Period</topic><topic>risk</topic><topic>Risk Factors</topic><topic>saturated fatty acids</topic><topic>Single-Blind Method</topic><topic>students</topic><topic>Thrombosis - blood</topic><topic>Thrombosis - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, Ruth D.</creatorcontrib><creatorcontrib>Kelly, Colette N. 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Renuka R.</creatorcontrib><creatorcontrib>Nydahl, Margaretha C.</creatorcontrib><creatorcontrib>Miller, George J.</creatorcontrib><creatorcontrib>Williams, Christine M.</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, Ruth D.</au><au>Kelly, Colette N. M.</au><au>Fielding, Barbara A.</au><au>Hauton, David</au><au>Silva, K. D. Renuka R.</au><au>Nydahl, Margaretha C.</au><au>Miller, George J.</au><au>Williams, Christine M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2003-09-01</date><risdate>2003</risdate><volume>90</volume><issue>3</issue><spage>597</spage><epage>606</epage><pages>597-606</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><abstract><![CDATA[The aim of the present study was to compare the response of a range of atherogenic and thrombogenic risk markers to two dietary levels of saturated fatty acid (SFA) substitution with monounsaturated fatty acids (MUFA) in students living in a university hall of residence. Although the benefits of such diets have been reported for plasma lipoproteins in high-risk groups, more needs to be known about effects of more modest SFA-MUFA substitutions over the long term and in young healthy adults. In a parallel design over 16 weeks, fifty-one healthy young subjects were randomised to one of two diets: (1) a moderate-MUFA diet in which 16 g dietary SFA/100 g total fatty acids were substituted with MUFA (n 25); (2) a high-MUFA diet in which 33 g dietary SFA/100 g total fatty acids were substituted with MUFA (n 26). All subjects followed an 8-week run-in diet (reference diet), with a fatty acid composition close to the UK average values. There were no differences in plasma lipid responses between the two diets over 16 weeks of the study with similar reductions in total cholesterol (P <0·001) and LDL-cholesterol (P<0·01) in both groups; a small but significant reduction in HDL-cholesterol was also observed in both groups (P<0·01). Platelet responses to ADP (P<0·01) and arachidonic acid (P<0·05) differed with time on the two diets; at 16 weeks, platelet aggregatory response to ADP was significantly lower on the high-MUFA than the moderate-MUFA (P<0·01) diet; ADP responses were also significantly lower within this group at 8 (P<0·05) and 16 (P<0·01) weeks compared with baseline. There were no differences in fasting factor VII activity (factors VIIc and VIIag), fibrinogen concentration or tissue-type plasminogen activator activity between the diets. There were no differences in postprandial factor VIIc responses to a standard meal (area under the curve) between the diets after 16 weeks, but postprandial factor VIIc response was lower than on the high-MUFA diet compared with baseline (P<0·01). In conclusion, a high-MUFA diet sustains potentially beneficial effects on platelet aggregation and postprandial activation of factor VII. Moderate or high substitution of MUFA for SFA achieves similar reductions in fasting blood lipids in young healthy subjects.]]></abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>13129466</pmid><doi>10.1079/BJN2003953</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | adenosine diphosphate Adult adults Analysis of Variance arachidonic acid Area Under Curve Arteriosclerosis - blood Arteriosclerosis - prevention & control blood lipids Cholesterol Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Coagulation Diet Dietary Fats, Unsaturated - administration & dosage factor VII Factor VII - metabolism fasting fatty acid composition Fatty acids Fatty Acids, Monounsaturated - administration & dosage Female fibrinogen high density lipoprotein cholesterol Humans Lipids low density lipoprotein cholesterol Male monounsaturated fatty acids Monunsaturated fatty acids plasminogen activator Platelet Aggregation Postprandial Period risk Risk Factors saturated fatty acids Single-Blind Method students Thrombosis - blood Thrombosis - prevention & control |
| title | Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects |
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