DQAsome-mediated delivery of plasmid DNA toward mitochondria in living cells

DQAsomes are mitochondriotropic cationic ‘bola-lipid’-based vesicles, which have been developed by us for the transport of drugs and DNA to mitochondria in living cells. This has made direct mitochondrial gene therapy feasible for the very first time. Our strategy for the delivery of DNA into the ma...

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Veröffentlicht in:	Journal of controlled release 2003-09, Vol.92 (1), p.189-197
Hauptverfasser:	D’Souza, Gerard G.M, Rammohan, Ram, Cheng, Shing-Ming, Torchilin, Vladimir P, Weissig, Volkmar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Dequalinium Dequalinium - administration & dosage Dequalinium - pharmacokinetics DNA - administration & dosage DNA - pharmacokinetics DNA delivery DQAsomes Drug Delivery Systems - methods Gene therapy General pharmacology Humans Liposomes Medical sciences Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondrial targeting Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Plasmids - administration & dosage Plasmids - pharmacokinetics Rats
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