Genetically modified filamentous phage as bactericidal agents: a pilot study

Aims: To evaluate the ability of a filamentous phage encoding lethal proteins to kill bacteria without host‐cell lysis. Methods and Results: Bacterial survival was determined after infection of a growing Escherichia coli culture with phage M13 encoding either the restriction endonuclease BglII gene...

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Veröffentlicht in:	Letters in applied microbiology 2003-01, Vol.37 (4), p.318-323
Hauptverfasser:	Hagens, S., Bläsi, U.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Infections - therapy Bacteriophage M13 - genetics Bacteriophage M13 - physiology bacteriophage therapy Biological and medical sciences Deoxyribonucleases, Type II Site-Specific - genetics Escherichia coli - virology Fundamental and applied biological sciences. Psychology Genetic Engineering - methods Genetic Therapy Humans lysis Microbiology restrictionendonuclease Viral Proteins - genetics
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