Comparative efficacy of Keishi-bukuryo-gan and Pentoxifylline on RBC deformability in patients with “oketsu” syndrome
Keishi-bukuryo-gan (Gui-Zhi-Fu-Ling-Wan) (KBG) is one of the prescriptions in Japanese traditional medicine for improving the “oketsu” syndrome, so-called blood stasis syndrome. “Oketsu” syndrome is an important pathological conception in Japanese traditional medicine and often accompanies cerebro-v...
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| Veröffentlicht in: | Phytomedicine (Stuttgart) 2003-01, Vol.10 (6), p.459-466 |
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| creator | Hikiami, H. Goto, H. Sekiya, N. Hattori, N. Sakakibara, I. Shimada, Y. Terasawa, K. |
| description | Keishi-bukuryo-gan (Gui-Zhi-Fu-Ling-Wan) (KBG) is one of the prescriptions in Japanese traditional medicine for improving the “oketsu” syndrome, so-called blood stasis syndrome. “Oketsu” syndrome is an important pathological conception in Japanese traditional medicine and often accompanies cerebro-vascular disorders. Previously, we were able to reveal a deterioration of RBC (Red blood cell) deformability and viscoelasticity in patients with “oketsu” syndrome. The purpose of the present study was to evaluate whether KBG has an effect on RBC deformability in comparison with pentoxifylline (PXF). The subjects were 30 male patients with multiple lacunar infarctions. Eighteen patients (44–79 yrs, mean ±SD, 66.1 ± 10.7 yrs) were treated with 12 g of KBG daily for 4 weeks (KBG group). Twelve patients (59–78 yrs, 70.7 ± 6.4 yrs) were treated with 300 mg of PXF daily for 4 weeks (PXF group). Based on the “oketsu” score, the patients of each group were divided into two subgroups, a non-“oketsu” group (“oketsu” score 20 points or less) and an “oketsu” group (“oketsu” score 21 points or higher). KBG had significant effects on RBC deformability as evaluated by filtration method. KBG also significantly increased intracellular ATP content, as did PXF. Moreover, KBG was more effective for patients with a more severe “oketsu” state. However, PXF was effective only in patients with “oketsu” syndrome, who might have deteriorated RBC deformability. In conclusion, the effect of KBG on RBC deformability was by no means inferior to PXF. |
| doi_str_mv | 10.1078/094471103322331395 |
| format | Article |
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Previously, we were able to reveal a deterioration of RBC (Red blood cell) deformability and viscoelasticity in patients with “oketsu” syndrome. The purpose of the present study was to evaluate whether KBG has an effect on RBC deformability in comparison with pentoxifylline (PXF). The subjects were 30 male patients with multiple lacunar infarctions. Eighteen patients (44–79 yrs, mean ±SD, 66.1 ± 10.7 yrs) were treated with 12 g of KBG daily for 4 weeks (KBG group). Twelve patients (59–78 yrs, 70.7 ± 6.4 yrs) were treated with 300 mg of PXF daily for 4 weeks (PXF group). Based on the “oketsu” score, the patients of each group were divided into two subgroups, a non-“oketsu” group (“oketsu” score 20 points or less) and an “oketsu” group (“oketsu” score 21 points or higher). KBG had significant effects on RBC deformability as evaluated by filtration method. KBG also significantly increased intracellular ATP content, as did PXF. Moreover, KBG was more effective for patients with a more severe “oketsu” state. However, PXF was effective only in patients with “oketsu” syndrome, who might have deteriorated RBC deformability. In conclusion, the effect of KBG on RBC deformability was by no means inferior to PXF.</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1078/094471103322331395</identifier><identifier>PMID: 13678228</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Administration, Oral ; Adult ; Aged ; Blood ; Cerebral Infarction - drug therapy ; Cerebral Infarction - pathology ; Chromatography, High Pressure Liquid ; Drug therapy ; Drugs, Chinese Herbal - administration & dosage ; Drugs, Chinese Herbal - pharmacology ; Drugs, Chinese Herbal - therapeutic use ; Erythrocyte Deformability - drug effects ; Erythrocytes ; Evaluation ; Hemolysis - drug effects ; hemorheology ; Humans ; Japan ; Kampo medicine ; Keishi-bukuryo-gan ; Male ; Medicinal plants ; Medicine, Traditional ; Middle Aged ; Pentoxifylline ; Pentoxifylline - administration & dosage ; Pentoxifylline - pharmacology ; Pentoxifylline - therapeutic use ; Phytotherapy ; Platelet Aggregation Inhibitors - administration & dosage ; Platelet Aggregation Inhibitors - pharmacology ; Platelet Aggregation Inhibitors - therapeutic use ; RBC deformability ; Rheology ; Severity of Illness Index ; Statistics ; Treatment Outcome</subject><ispartof>Phytomedicine (Stuttgart), 2003-01, Vol.10 (6), p.459-466</ispartof><rights>2003 Urban & Fischer Verlag</rights><rights>COPYRIGHT 2003 Urban & Fischer Verlag</rights><rights>Copyright Urban & Fischer Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-feb6ed5eef287706051aff2413f11c0f646c301beabf9ad343e47c12888d84b93</citedby><cites>FETCH-LOGICAL-c456t-feb6ed5eef287706051aff2413f11c0f646c301beabf9ad343e47c12888d84b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0944711304702482$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13678228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hikiami, H.</creatorcontrib><creatorcontrib>Goto, H.</creatorcontrib><creatorcontrib>Sekiya, N.</creatorcontrib><creatorcontrib>Hattori, N.</creatorcontrib><creatorcontrib>Sakakibara, I.</creatorcontrib><creatorcontrib>Shimada, Y.</creatorcontrib><creatorcontrib>Terasawa, K.</creatorcontrib><title>Comparative efficacy of Keishi-bukuryo-gan and Pentoxifylline on RBC deformability in patients with “oketsu” syndrome</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>Keishi-bukuryo-gan (Gui-Zhi-Fu-Ling-Wan) (KBG) is one of the prescriptions in Japanese traditional medicine for improving the “oketsu” syndrome, so-called blood stasis syndrome. “Oketsu” syndrome is an important pathological conception in Japanese traditional medicine and often accompanies cerebro-vascular disorders. Previously, we were able to reveal a deterioration of RBC (Red blood cell) deformability and viscoelasticity in patients with “oketsu” syndrome. The purpose of the present study was to evaluate whether KBG has an effect on RBC deformability in comparison with pentoxifylline (PXF). The subjects were 30 male patients with multiple lacunar infarctions. Eighteen patients (44–79 yrs, mean ±SD, 66.1 ± 10.7 yrs) were treated with 12 g of KBG daily for 4 weeks (KBG group). Twelve patients (59–78 yrs, 70.7 ± 6.4 yrs) were treated with 300 mg of PXF daily for 4 weeks (PXF group). Based on the “oketsu” score, the patients of each group were divided into two subgroups, a non-“oketsu” group (“oketsu” score 20 points or less) and an “oketsu” group (“oketsu” score 21 points or higher). KBG had significant effects on RBC deformability as evaluated by filtration method. KBG also significantly increased intracellular ATP content, as did PXF. Moreover, KBG was more effective for patients with a more severe “oketsu” state. However, PXF was effective only in patients with “oketsu” syndrome, who might have deteriorated RBC deformability. In conclusion, the effect of KBG on RBC deformability was by no means inferior to PXF.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Aged</subject><subject>Blood</subject><subject>Cerebral Infarction - drug therapy</subject><subject>Cerebral Infarction - pathology</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Drug therapy</subject><subject>Drugs, Chinese Herbal - administration & dosage</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>Erythrocyte Deformability - drug effects</subject><subject>Erythrocytes</subject><subject>Evaluation</subject><subject>Hemolysis - drug effects</subject><subject>hemorheology</subject><subject>Humans</subject><subject>Japan</subject><subject>Kampo medicine</subject><subject>Keishi-bukuryo-gan</subject><subject>Male</subject><subject>Medicinal plants</subject><subject>Medicine, Traditional</subject><subject>Middle Aged</subject><subject>Pentoxifylline</subject><subject>Pentoxifylline - administration & dosage</subject><subject>Pentoxifylline - pharmacology</subject><subject>Pentoxifylline - therapeutic use</subject><subject>Phytotherapy</subject><subject>Platelet Aggregation Inhibitors - administration & dosage</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>Platelet Aggregation Inhibitors - therapeutic use</subject><subject>RBC deformability</subject><subject>Rheology</subject><subject>Severity of Illness Index</subject><subject>Statistics</subject><subject>Treatment Outcome</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp90c9qFTEUBvAgir2tvoALCS7cTc2_mcyAm3qxKhYUUXAXMsnJbdqZ5JrMVGfXB9GX65OYci8IWiSLQPh9h0M-hJ5QckyJbF-QTghJKeGcMc4p7-p7aEUb2lakq7_eR6tbUBXBD9BhzheEUNFJ8hAdUN7IlrF2hZZ1HLc66clfAQbnvNFmwdHh9-Dzua_6-XJOS6w2OmAdLP4IYYo_vFuGwQfAMeBPr9bYgotp1L0f_LRgH_C2DCwy4-9-Osc31z_jJUx5vrn-hfMSbIojPEIPnB4yPN7fR-jL6evP67fV2Yc379YnZ5URdTNVDvoGbA3gWCslaUhNtXNMUO4oNcQ1ojGc0B507zptueAgpKGsbVvbir7jR-j5bu42xW8z5EmNPhsYBh0gzllJ3tSccFbgs7_gRZxTKLspRupaECJlQdUObfQAygcXp6TNBgIkPcQAzpfnE0o6whohRPHHd_hyLIze3Blgu4BJMecETm2TH3VaFCXqtnb1b-0l9HS_-tyPYP9E9j0X8HIHoPz0lYeksikFGbA-gZmUjf5_838DXMy8xA</recordid><startdate>20030101</startdate><enddate>20030101</enddate><creator>Hikiami, H.</creator><creator>Goto, H.</creator><creator>Sekiya, N.</creator><creator>Hattori, N.</creator><creator>Sakakibara, I.</creator><creator>Shimada, Y.</creator><creator>Terasawa, K.</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20030101</creationdate><title>Comparative efficacy of Keishi-bukuryo-gan and Pentoxifylline on RBC deformability in patients with “oketsu” syndrome</title><author>Hikiami, H. ; Goto, H. ; Sekiya, N. ; Hattori, N. ; Sakakibara, I. ; Shimada, Y. ; Terasawa, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-feb6ed5eef287706051aff2413f11c0f646c301beabf9ad343e47c12888d84b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Aged</topic><topic>Blood</topic><topic>Cerebral Infarction - drug therapy</topic><topic>Cerebral Infarction - pathology</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Drug therapy</topic><topic>Drugs, Chinese Herbal - administration & dosage</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Drugs, Chinese Herbal - therapeutic use</topic><topic>Erythrocyte Deformability - drug effects</topic><topic>Erythrocytes</topic><topic>Evaluation</topic><topic>Hemolysis - drug effects</topic><topic>hemorheology</topic><topic>Humans</topic><topic>Japan</topic><topic>Kampo medicine</topic><topic>Keishi-bukuryo-gan</topic><topic>Male</topic><topic>Medicinal plants</topic><topic>Medicine, Traditional</topic><topic>Middle Aged</topic><topic>Pentoxifylline</topic><topic>Pentoxifylline - administration & dosage</topic><topic>Pentoxifylline - pharmacology</topic><topic>Pentoxifylline - therapeutic use</topic><topic>Phytotherapy</topic><topic>Platelet Aggregation Inhibitors - administration & dosage</topic><topic>Platelet Aggregation Inhibitors - 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Academic</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hikiami, H.</au><au>Goto, H.</au><au>Sekiya, N.</au><au>Hattori, N.</au><au>Sakakibara, I.</au><au>Shimada, Y.</au><au>Terasawa, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative efficacy of Keishi-bukuryo-gan and Pentoxifylline on RBC deformability in patients with “oketsu” syndrome</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2003-01-01</date><risdate>2003</risdate><volume>10</volume><issue>6</issue><spage>459</spage><epage>466</epage><pages>459-466</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>Keishi-bukuryo-gan (Gui-Zhi-Fu-Ling-Wan) (KBG) is one of the prescriptions in Japanese traditional medicine for improving the “oketsu” syndrome, so-called blood stasis syndrome. “Oketsu” syndrome is an important pathological conception in Japanese traditional medicine and often accompanies cerebro-vascular disorders. Previously, we were able to reveal a deterioration of RBC (Red blood cell) deformability and viscoelasticity in patients with “oketsu” syndrome. The purpose of the present study was to evaluate whether KBG has an effect on RBC deformability in comparison with pentoxifylline (PXF). The subjects were 30 male patients with multiple lacunar infarctions. Eighteen patients (44–79 yrs, mean ±SD, 66.1 ± 10.7 yrs) were treated with 12 g of KBG daily for 4 weeks (KBG group). Twelve patients (59–78 yrs, 70.7 ± 6.4 yrs) were treated with 300 mg of PXF daily for 4 weeks (PXF group). Based on the “oketsu” score, the patients of each group were divided into two subgroups, a non-“oketsu” group (“oketsu” score 20 points or less) and an “oketsu” group (“oketsu” score 21 points or higher). KBG had significant effects on RBC deformability as evaluated by filtration method. KBG also significantly increased intracellular ATP content, as did PXF. Moreover, KBG was more effective for patients with a more severe “oketsu” state. However, PXF was effective only in patients with “oketsu” syndrome, who might have deteriorated RBC deformability. In conclusion, the effect of KBG on RBC deformability was by no means inferior to PXF.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>13678228</pmid><doi>10.1078/094471103322331395</doi><tpages>8</tpages></addata></record> |
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| ispartof | Phytomedicine (Stuttgart), 2003-01, Vol.10 (6), p.459-466 |
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| subjects | Administration, Oral Adult Aged Blood Cerebral Infarction - drug therapy Cerebral Infarction - pathology Chromatography, High Pressure Liquid Drug therapy Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Erythrocyte Deformability - drug effects Erythrocytes Evaluation Hemolysis - drug effects hemorheology Humans Japan Kampo medicine Keishi-bukuryo-gan Male Medicinal plants Medicine, Traditional Middle Aged Pentoxifylline Pentoxifylline - administration & dosage Pentoxifylline - pharmacology Pentoxifylline - therapeutic use Phytotherapy Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - pharmacology Platelet Aggregation Inhibitors - therapeutic use RBC deformability Rheology Severity of Illness Index Statistics Treatment Outcome |
| title | Comparative efficacy of Keishi-bukuryo-gan and Pentoxifylline on RBC deformability in patients with “oketsu” syndrome |
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