Lispro insulin and metformin versus other combination in the diabetes mellitus type 2 management after secondary oral antidiabetic drug failure
The purpose of the study was to find out differences between treatments of diabetes type 2 after secondary oral antidiabetic drug failure. Three different methods of treatment were compared: lispro insulin in combination with metformin, glimepiride and metformin combination or two daily doses of bip...
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| Veröffentlicht in: | Collegium antropologicum 2003-06, Vol.27 (1), p.181-187 |
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| container_title | Collegium antropologicum |
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| creator | Kokić, Slaven Buković, Damir Radman, Maja Capkun, Vesna Gabrić, Nikica Lesko, Vesna Karelović, Deni Stancerić, Tajana |
| description | The purpose of the study was to find out differences between treatments of diabetes type 2 after secondary oral antidiabetic drug failure. Three different methods of treatment were compared: lispro insulin in combination with metformin, glimepiride and metformin combination or two daily doses of biphasic insulin 30/70 together with bed-time NPH insulin. The study included 87 patients with diabetes mellitus type 2 randomly distributed into 3 different treatment groups. Fasting and postprandial glucose were analyzed by enzymatic colorimetric method and HbA1c was measured by ion exchange chromatography. HbA1c significantly decreased in all three study groups. The decrease was mostly expressed among patients treated with lispro and metformin. When focused on postprandial glucose control, antihyperglycemic metformin and insulin lispro therapy has greater impact on the overall metabolic control (decrease in level of HbA1c) in comparison with the above mentioned more traditional approaches. |
| format | Article |
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Three different methods of treatment were compared: lispro insulin in combination with metformin, glimepiride and metformin combination or two daily doses of biphasic insulin 30/70 together with bed-time NPH insulin. The study included 87 patients with diabetes mellitus type 2 randomly distributed into 3 different treatment groups. Fasting and postprandial glucose were analyzed by enzymatic colorimetric method and HbA1c was measured by ion exchange chromatography. HbA1c significantly decreased in all three study groups. The decrease was mostly expressed among patients treated with lispro and metformin. When focused on postprandial glucose control, antihyperglycemic metformin and insulin lispro therapy has greater impact on the overall metabolic control (decrease in level of HbA1c) in comparison with the above mentioned more traditional approaches.</description><identifier>ISSN: 0350-6134</identifier><identifier>PMID: 12974145</identifier><language>eng</language><publisher>Croatia</publisher><subject>Administration, Oral ; Aged ; Blood Glucose - analysis ; Diabetes Mellitus, Type 2 - drug therapy ; Drug Therapy, Combination ; Female ; Humans ; Hypoglycemic Agents - administration & dosage ; Hypoglycemic Agents - pharmacology ; Insulin - administration & dosage ; Insulin - analogs & derivatives ; Insulin - pharmacology ; Insulin Lispro ; Male ; Metformin - administration & dosage ; Metformin - pharmacology ; Middle Aged ; Postprandial Period ; Sulfonylurea Compounds - administration & dosage ; Sulfonylurea Compounds - pharmacology ; Treatment Outcome</subject><ispartof>Collegium antropologicum, 2003-06, Vol.27 (1), p.181-187</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12974145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kokić, Slaven</creatorcontrib><creatorcontrib>Buković, Damir</creatorcontrib><creatorcontrib>Radman, Maja</creatorcontrib><creatorcontrib>Capkun, Vesna</creatorcontrib><creatorcontrib>Gabrić, Nikica</creatorcontrib><creatorcontrib>Lesko, Vesna</creatorcontrib><creatorcontrib>Karelović, Deni</creatorcontrib><creatorcontrib>Stancerić, Tajana</creatorcontrib><title>Lispro insulin and metformin versus other combination in the diabetes mellitus type 2 management after secondary oral antidiabetic drug failure</title><title>Collegium antropologicum</title><addtitle>Coll Antropol</addtitle><description>The purpose of the study was to find out differences between treatments of diabetes type 2 after secondary oral antidiabetic drug failure. Three different methods of treatment were compared: lispro insulin in combination with metformin, glimepiride and metformin combination or two daily doses of biphasic insulin 30/70 together with bed-time NPH insulin. The study included 87 patients with diabetes mellitus type 2 randomly distributed into 3 different treatment groups. Fasting and postprandial glucose were analyzed by enzymatic colorimetric method and HbA1c was measured by ion exchange chromatography. HbA1c significantly decreased in all three study groups. The decrease was mostly expressed among patients treated with lispro and metformin. When focused on postprandial glucose control, antihyperglycemic metformin and insulin lispro therapy has greater impact on the overall metabolic control (decrease in level of HbA1c) in comparison with the above mentioned more traditional approaches.</description><subject>Administration, Oral</subject><subject>Aged</subject><subject>Blood Glucose - analysis</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Humans</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Insulin - administration & dosage</subject><subject>Insulin - analogs & derivatives</subject><subject>Insulin - pharmacology</subject><subject>Insulin Lispro</subject><subject>Male</subject><subject>Metformin - administration & dosage</subject><subject>Metformin - pharmacology</subject><subject>Middle Aged</subject><subject>Postprandial Period</subject><subject>Sulfonylurea Compounds - administration & dosage</subject><subject>Sulfonylurea Compounds - pharmacology</subject><subject>Treatment Outcome</subject><issn>0350-6134</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE1PxCAQhnvQuOvqXzCcvDWhUNpyNBu_kiZe9NzwMayYAhWoyf4K_7Iku54YJs8zk3cuqi2mDNddQ9tNdZ3SF8as73B3VW0awvu2adm2-h1tWmJA1qd1th4Jr5GDbEJ05fcDMa0JhfwJEangpPUi2-ALjkoPaSskZEhFmWebC5qPCyCCnPDiAA58RsLkIidQwWsRjyhEMZc12Z5kq5CO6wEZYec1wk11acSc4Pb87qqPp8f3_Us9vj2_7h_GeiG4z7UZWq2BcT4MopFGlUIaDgNwzbiBjgje067rG4KZVIarXmKlMZWGMiKZobvq_jS3hP9eIeXJ2aRKCuEhrGkqNiMdaQp4dwZX6UBPS7SuxJj-T0j_AGXXcJk</recordid><startdate>20030601</startdate><enddate>20030601</enddate><creator>Kokić, Slaven</creator><creator>Buković, Damir</creator><creator>Radman, Maja</creator><creator>Capkun, Vesna</creator><creator>Gabrić, Nikica</creator><creator>Lesko, Vesna</creator><creator>Karelović, Deni</creator><creator>Stancerić, Tajana</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20030601</creationdate><title>Lispro insulin and metformin versus other combination in the diabetes mellitus type 2 management after secondary oral antidiabetic drug failure</title><author>Kokić, Slaven ; Buković, Damir ; Radman, Maja ; Capkun, Vesna ; Gabrić, Nikica ; Lesko, Vesna ; Karelović, Deni ; Stancerić, Tajana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p207t-f84dde59988a1bfc998bf9e8e9d59fe62a9736671205bcf9c7b0cd03bf352b5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Administration, Oral</topic><topic>Aged</topic><topic>Blood Glucose - analysis</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Humans</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Insulin - administration & dosage</topic><topic>Insulin - analogs & derivatives</topic><topic>Insulin - pharmacology</topic><topic>Insulin Lispro</topic><topic>Male</topic><topic>Metformin - administration & dosage</topic><topic>Metformin - pharmacology</topic><topic>Middle Aged</topic><topic>Postprandial Period</topic><topic>Sulfonylurea Compounds - administration & dosage</topic><topic>Sulfonylurea Compounds - pharmacology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kokić, Slaven</creatorcontrib><creatorcontrib>Buković, Damir</creatorcontrib><creatorcontrib>Radman, Maja</creatorcontrib><creatorcontrib>Capkun, Vesna</creatorcontrib><creatorcontrib>Gabrić, Nikica</creatorcontrib><creatorcontrib>Lesko, Vesna</creatorcontrib><creatorcontrib>Karelović, Deni</creatorcontrib><creatorcontrib>Stancerić, Tajana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Collegium antropologicum</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kokić, Slaven</au><au>Buković, Damir</au><au>Radman, Maja</au><au>Capkun, Vesna</au><au>Gabrić, Nikica</au><au>Lesko, Vesna</au><au>Karelović, Deni</au><au>Stancerić, Tajana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lispro insulin and metformin versus other combination in the diabetes mellitus type 2 management after secondary oral antidiabetic drug failure</atitle><jtitle>Collegium antropologicum</jtitle><addtitle>Coll Antropol</addtitle><date>2003-06-01</date><risdate>2003</risdate><volume>27</volume><issue>1</issue><spage>181</spage><epage>187</epage><pages>181-187</pages><issn>0350-6134</issn><abstract>The purpose of the study was to find out differences between treatments of diabetes type 2 after secondary oral antidiabetic drug failure. Three different methods of treatment were compared: lispro insulin in combination with metformin, glimepiride and metformin combination or two daily doses of biphasic insulin 30/70 together with bed-time NPH insulin. The study included 87 patients with diabetes mellitus type 2 randomly distributed into 3 different treatment groups. Fasting and postprandial glucose were analyzed by enzymatic colorimetric method and HbA1c was measured by ion exchange chromatography. HbA1c significantly decreased in all three study groups. The decrease was mostly expressed among patients treated with lispro and metformin. When focused on postprandial glucose control, antihyperglycemic metformin and insulin lispro therapy has greater impact on the overall metabolic control (decrease in level of HbA1c) in comparison with the above mentioned more traditional approaches.</abstract><cop>Croatia</cop><pmid>12974145</pmid><tpages>7</tpages></addata></record> |
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| ispartof | Collegium antropologicum, 2003-06, Vol.27 (1), p.181-187 |
| issn | 0350-6134 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Administration, Oral Aged Blood Glucose - analysis Diabetes Mellitus, Type 2 - drug therapy Drug Therapy, Combination Female Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacology Insulin - administration & dosage Insulin - analogs & derivatives Insulin - pharmacology Insulin Lispro Male Metformin - administration & dosage Metformin - pharmacology Middle Aged Postprandial Period Sulfonylurea Compounds - administration & dosage Sulfonylurea Compounds - pharmacology Treatment Outcome |
| title | Lispro insulin and metformin versus other combination in the diabetes mellitus type 2 management after secondary oral antidiabetic drug failure |
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