Evaluation of the gonadotropic responsiveness of the pituitary to acute and prolonged administration of LH/FSH-releasing hormone (lhrh) in untreated patients with congenital adrenal hyperplasia
The pituitary gonadotropic responsiveness to acute and prolonged administration of LH/FSH-releasing hormone (LHRH) were assessed in 6 patients with untreated congenital virilizing adrenal hyperplasia (partial 21-hydroxylase deficiency). The oldest subjects had normal response in comparison to female...
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| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 1981-10, Vol.30 (10), p.976-981 |
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| container_end_page | 981 |
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| container_issue | 10 |
| container_start_page | 976 |
| container_title | Metabolism, clinical and experimental |
| container_volume | 30 |
| creator | Wajchenberg, B L Pinto, H Achando, S S Kiyan, T S Okada, H Goldman, J Betti, R T Liberman, B Thomsen, I L |
| description | The pituitary gonadotropic responsiveness to acute and prolonged administration of LH/FSH-releasing hormone (LHRH) were assessed in 6 patients with untreated congenital virilizing adrenal hyperplasia (partial 21-hydroxylase deficiency). The oldest subjects had normal response in comparison to females at the midfollicular phase, to the acute infusion of 25 ug LHRH regarding both gonadotropins whereas LH secretory area was decreased during the prolonged (100 ug LHRH in 8 hours) infusion with normal FSH secretion. The two youngest subjects, with higher steroid levels in our series, were either unresponsive on both ways of testing or presented pre-pubertal response. |
| doi_str_mv | 10.1016/0026-0495(81)90095-0 |
| format | Article |
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The oldest subjects had normal response in comparison to females at the midfollicular phase, to the acute infusion of 25 ug LHRH regarding both gonadotropins whereas LH secretory area was decreased during the prolonged (100 ug LHRH in 8 hours) infusion with normal FSH secretion. The two youngest subjects, with higher steroid levels in our series, were either unresponsive on both ways of testing or presented pre-pubertal response.</description><identifier>ISSN: 0026-0495</identifier><identifier>DOI: 10.1016/0026-0495(81)90095-0</identifier><identifier>PMID: 7024724</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Adrenal Hyperplasia, Congenital - blood ; Adrenal Hyperplasia, Congenital - complications ; Adult ; Androgens - blood ; Child ; Estrogens - blood ; Female ; Gonadotropin-Releasing Hormone ; Humans ; Hydroxyprogesterones - blood ; Pituitary Gland - drug effects ; Pituitary Gland - metabolism ; Progesterone - blood ; Virilism - blood ; Virilism - complications</subject><ispartof>Metabolism, clinical and experimental, 1981-10, Vol.30 (10), p.976-981</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7024724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wajchenberg, B L</creatorcontrib><creatorcontrib>Pinto, H</creatorcontrib><creatorcontrib>Achando, S S</creatorcontrib><creatorcontrib>Kiyan, T S</creatorcontrib><creatorcontrib>Okada, H</creatorcontrib><creatorcontrib>Goldman, J</creatorcontrib><creatorcontrib>Betti, R T</creatorcontrib><creatorcontrib>Liberman, B</creatorcontrib><creatorcontrib>Thomsen, I L</creatorcontrib><title>Evaluation of the gonadotropic responsiveness of the pituitary to acute and prolonged administration of LH/FSH-releasing hormone (lhrh) in untreated patients with congenital adrenal hyperplasia</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>The pituitary gonadotropic responsiveness to acute and prolonged administration of LH/FSH-releasing hormone (LHRH) were assessed in 6 patients with untreated congenital virilizing adrenal hyperplasia (partial 21-hydroxylase deficiency). The oldest subjects had normal response in comparison to females at the midfollicular phase, to the acute infusion of 25 ug LHRH regarding both gonadotropins whereas LH secretory area was decreased during the prolonged (100 ug LHRH in 8 hours) infusion with normal FSH secretion. The two youngest subjects, with higher steroid levels in our series, were either unresponsive on both ways of testing or presented pre-pubertal response.</description><subject>Adolescent</subject><subject>Adrenal Hyperplasia, Congenital - blood</subject><subject>Adrenal Hyperplasia, Congenital - complications</subject><subject>Adult</subject><subject>Androgens - blood</subject><subject>Child</subject><subject>Estrogens - blood</subject><subject>Female</subject><subject>Gonadotropin-Releasing Hormone</subject><subject>Humans</subject><subject>Hydroxyprogesterones - blood</subject><subject>Pituitary Gland - drug effects</subject><subject>Pituitary Gland - metabolism</subject><subject>Progesterone - blood</subject><subject>Virilism - blood</subject><subject>Virilism - complications</subject><issn>0026-0495</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1OwzAQhH0A8VN4A5B8QvQQsPPjNEeEWopUiQNwrrbJujFybGM7oD4eb4YRhb2MtJr5VjuEXHB2wxkXt4zlImNlU13P-LRhrKkydkBO_tfH5DSEN8ZYXc_EETmqWV7WeXlCvuYfoEeIyhpqJY090q010NnorVMt9RicNUF9oMEQ_ixOxVFF8DsaLYV2jEjBdNR5q63ZYkehG5RRIfp_8mp5u3heZh41QlBmS3vrB2uQXuve91OqDB1N9AgxxV2KoYmBfqrY0_aHadI9nbgeTdJ-59A7nUhwRg4l6IDne52Q18X85X6ZrZ4eHu_vVpnLmYjZpgNZlEWaSgheoRQ1h0bOmoLnTEJdlS1UGwlQlh1yKSVjFReQ53lTzlohigm5-uWmL99HDHE9qNCi1mDQjmFdF6JKvTfJeLk3jpsBu7XzakhVrfedF984aIeV</recordid><startdate>198110</startdate><enddate>198110</enddate><creator>Wajchenberg, B L</creator><creator>Pinto, H</creator><creator>Achando, S S</creator><creator>Kiyan, T S</creator><creator>Okada, H</creator><creator>Goldman, J</creator><creator>Betti, R T</creator><creator>Liberman, B</creator><creator>Thomsen, I L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198110</creationdate><title>Evaluation of the gonadotropic responsiveness of the pituitary to acute and prolonged administration of LH/FSH-releasing hormone (lhrh) in untreated patients with congenital adrenal hyperplasia</title><author>Wajchenberg, B L ; Pinto, H ; Achando, S S ; Kiyan, T S ; Okada, H ; Goldman, J ; Betti, R T ; Liberman, B ; Thomsen, I L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p206t-bdaf34333356615ef671a9f893120fa754ca5bfaa44de1fff00516a222948c663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Adolescent</topic><topic>Adrenal Hyperplasia, Congenital - blood</topic><topic>Adrenal Hyperplasia, Congenital - complications</topic><topic>Adult</topic><topic>Androgens - blood</topic><topic>Child</topic><topic>Estrogens - blood</topic><topic>Female</topic><topic>Gonadotropin-Releasing Hormone</topic><topic>Humans</topic><topic>Hydroxyprogesterones - blood</topic><topic>Pituitary Gland - drug effects</topic><topic>Pituitary Gland - metabolism</topic><topic>Progesterone - blood</topic><topic>Virilism - blood</topic><topic>Virilism - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wajchenberg, B L</creatorcontrib><creatorcontrib>Pinto, H</creatorcontrib><creatorcontrib>Achando, S S</creatorcontrib><creatorcontrib>Kiyan, T S</creatorcontrib><creatorcontrib>Okada, H</creatorcontrib><creatorcontrib>Goldman, J</creatorcontrib><creatorcontrib>Betti, R T</creatorcontrib><creatorcontrib>Liberman, B</creatorcontrib><creatorcontrib>Thomsen, I L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wajchenberg, B L</au><au>Pinto, H</au><au>Achando, S S</au><au>Kiyan, T S</au><au>Okada, H</au><au>Goldman, J</au><au>Betti, R T</au><au>Liberman, B</au><au>Thomsen, I L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the gonadotropic responsiveness of the pituitary to acute and prolonged administration of LH/FSH-releasing hormone (lhrh) in untreated patients with congenital adrenal hyperplasia</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>1981-10</date><risdate>1981</risdate><volume>30</volume><issue>10</issue><spage>976</spage><epage>981</epage><pages>976-981</pages><issn>0026-0495</issn><abstract>The pituitary gonadotropic responsiveness to acute and prolonged administration of LH/FSH-releasing hormone (LHRH) were assessed in 6 patients with untreated congenital virilizing adrenal hyperplasia (partial 21-hydroxylase deficiency). The oldest subjects had normal response in comparison to females at the midfollicular phase, to the acute infusion of 25 ug LHRH regarding both gonadotropins whereas LH secretory area was decreased during the prolonged (100 ug LHRH in 8 hours) infusion with normal FSH secretion. The two youngest subjects, with higher steroid levels in our series, were either unresponsive on both ways of testing or presented pre-pubertal response.</abstract><cop>United States</cop><pmid>7024724</pmid><doi>10.1016/0026-0495(81)90095-0</doi><tpages>6</tpages></addata></record> |
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| ispartof | Metabolism, clinical and experimental, 1981-10, Vol.30 (10), p.976-981 |
| issn | 0026-0495 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adolescent Adrenal Hyperplasia, Congenital - blood Adrenal Hyperplasia, Congenital - complications Adult Androgens - blood Child Estrogens - blood Female Gonadotropin-Releasing Hormone Humans Hydroxyprogesterones - blood Pituitary Gland - drug effects Pituitary Gland - metabolism Progesterone - blood Virilism - blood Virilism - complications |
| title | Evaluation of the gonadotropic responsiveness of the pituitary to acute and prolonged administration of LH/FSH-releasing hormone (lhrh) in untreated patients with congenital adrenal hyperplasia |
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