Thyroid pathology in four patients with Cowden’s disease
Cowden’s disease (multiple hamartoma syndrome) is a rare genodermatosis, which carries an increased risk of malignancy, especially breast and thyroid carcinoma. Thyroid disease is the most common internal manifestation of the syndrome, but the histological features in benign cases have hitherto been...
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| Veröffentlicht in: | Pathology 2003-08, Vol.35 (4), p.311-314 |
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| container_title | Pathology |
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| creator | Hemmings, Christine T. |
| description | Cowden’s disease (multiple hamartoma syndrome) is a rare genodermatosis, which carries an increased risk of malignancy, especially breast and thyroid carcinoma. Thyroid disease is the most common internal manifestation of the syndrome, but the histological features in benign cases have hitherto been relatively poorly described. Thyroidectomy specimens from four patients with Cowden’s disease have been reported in our laboratory in recent years. A number of rather distinctive features were common to all, raising the possibility of a distinctive ‘Cowden’s thyroid’ phenotype. |
| doi_str_mv | 10.1080/0031302031000150533 |
| format | Article |
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Thyroid disease is the most common internal manifestation of the syndrome, but the histological features in benign cases have hitherto been relatively poorly described. Thyroidectomy specimens from four patients with Cowden’s disease have been reported in our laboratory in recent years. A number of rather distinctive features were common to all, raising the possibility of a distinctive ‘Cowden’s thyroid’ phenotype.</description><identifier>ISSN: 0031-3025</identifier><identifier>EISSN: 1465-3931</identifier><identifier>DOI: 10.1080/0031302031000150533</identifier><identifier>PMID: 12959766</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>adenomatoid nodules ; Cowden’s disease ; Female ; genodermatosis ; Hamartoma Syndrome, Multiple - complications ; Hamartoma Syndrome, Multiple - pathology ; Humans ; Male ; multiple hamartoma syndrome ; Pedigree ; Siblings ; Thyroid ; Thyroid Gland - pathology ; Thyroid Gland - surgery ; Thyroid Nodule - etiology ; Thyroid Nodule - pathology ; Thyroid Nodule - surgery</subject><ispartof>Pathology, 2003-08, Vol.35 (4), p.311-314</ispartof><rights>2003 Royal College of Pathologists of Australasia</rights><rights>2003 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-acf60995b2800d32886777229e84c2a0a7aaa7c51d3f8c7141066086a4a83a813</citedby><cites>FETCH-LOGICAL-c409t-acf60995b2800d32886777229e84c2a0a7aaa7c51d3f8c7141066086a4a83a813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/0031302031000150533$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/0031302031000150533$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,61221,61402</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12959766$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hemmings, Christine T.</creatorcontrib><title>Thyroid pathology in four patients with Cowden’s disease</title><title>Pathology</title><addtitle>Pathology</addtitle><description>Cowden’s disease (multiple hamartoma syndrome) is a rare genodermatosis, which carries an increased risk of malignancy, especially breast and thyroid carcinoma. Thyroid disease is the most common internal manifestation of the syndrome, but the histological features in benign cases have hitherto been relatively poorly described. Thyroidectomy specimens from four patients with Cowden’s disease have been reported in our laboratory in recent years. A number of rather distinctive features were common to all, raising the possibility of a distinctive ‘Cowden’s thyroid’ phenotype.</description><subject>adenomatoid nodules</subject><subject>Cowden’s disease</subject><subject>Female</subject><subject>genodermatosis</subject><subject>Hamartoma Syndrome, Multiple - complications</subject><subject>Hamartoma Syndrome, Multiple - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>multiple hamartoma syndrome</subject><subject>Pedigree</subject><subject>Siblings</subject><subject>Thyroid</subject><subject>Thyroid Gland - pathology</subject><subject>Thyroid Gland - surgery</subject><subject>Thyroid Nodule - etiology</subject><subject>Thyroid Nodule - pathology</subject><subject>Thyroid Nodule - surgery</subject><issn>0031-3025</issn><issn>1465-3931</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1KxDAQx4Moun48gSA9eatOmjZNBQ-y-AWCFz2H2XRqs3SbNekqe_M1fD2fxCy74EX0MgPD7z_D_Bg75nDGQcE5gOACslgBgBdQCLHFRjyXRSoqwbfZaEWkESn22H4I04jlSqldtsezqqhKKUfs4qldemfrZI5D6zr3skxsnzRu4VcTS_0Qknc7tMnYvdfUf318hqS2gTDQIdtpsAt0tOkH7Pnm-ml8lz483t6Prx5Sk0M1pGgaCVVVTDIFUItMKVmWZZZVpHKTIWCJiKUpeC0aZUqec5ASlMQclUDFxQE7Xe-de_e6oDDomQ2Gug57cougSyELUHkVQbEGjXcheGr03NsZ-qXmoFfK9C_KYupks34xmVH9k9k4isDlGrB94_wMW8JuaA160tPoqY-__3Ngk6co6c2S18FEsYZq68kMunb2z_w3j1mK_Q</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Hemmings, Christine T.</creator><general>Elsevier B.V</general><general>Informa UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030801</creationdate><title>Thyroid pathology in four patients with Cowden’s disease</title><author>Hemmings, Christine T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-acf60995b2800d32886777229e84c2a0a7aaa7c51d3f8c7141066086a4a83a813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>adenomatoid nodules</topic><topic>Cowden’s disease</topic><topic>Female</topic><topic>genodermatosis</topic><topic>Hamartoma Syndrome, Multiple - complications</topic><topic>Hamartoma Syndrome, Multiple - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>multiple hamartoma syndrome</topic><topic>Pedigree</topic><topic>Siblings</topic><topic>Thyroid</topic><topic>Thyroid Gland - pathology</topic><topic>Thyroid Gland - surgery</topic><topic>Thyroid Nodule - etiology</topic><topic>Thyroid Nodule - pathology</topic><topic>Thyroid Nodule - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hemmings, Christine T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hemmings, Christine T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thyroid pathology in four patients with Cowden’s disease</atitle><jtitle>Pathology</jtitle><addtitle>Pathology</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>35</volume><issue>4</issue><spage>311</spage><epage>314</epage><pages>311-314</pages><issn>0031-3025</issn><eissn>1465-3931</eissn><abstract>Cowden’s disease (multiple hamartoma syndrome) is a rare genodermatosis, which carries an increased risk of malignancy, especially breast and thyroid carcinoma. Thyroid disease is the most common internal manifestation of the syndrome, but the histological features in benign cases have hitherto been relatively poorly described. Thyroidectomy specimens from four patients with Cowden’s disease have been reported in our laboratory in recent years. A number of rather distinctive features were common to all, raising the possibility of a distinctive ‘Cowden’s thyroid’ phenotype.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>12959766</pmid><doi>10.1080/0031302031000150533</doi><tpages>4</tpages></addata></record> |
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| ispartof | Pathology, 2003-08, Vol.35 (4), p.311-314 |
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| language | eng |
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| source | MEDLINE; Taylor & Francis Journals Complete; Alma/SFX Local Collection |
| subjects | adenomatoid nodules Cowden’s disease Female genodermatosis Hamartoma Syndrome, Multiple - complications Hamartoma Syndrome, Multiple - pathology Humans Male multiple hamartoma syndrome Pedigree Siblings Thyroid Thyroid Gland - pathology Thyroid Gland - surgery Thyroid Nodule - etiology Thyroid Nodule - pathology Thyroid Nodule - surgery |
| title | Thyroid pathology in four patients with Cowden’s disease |
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