Ex Vivo Mechanical Evaluation of Carbonate Apatite-Collagen-Grafted Porous Poly-L-lactic Acid Membrane in Rabbit Calvarial Bone
Appropriate mechanical recovery is an important parameter in successful restoration of skeletal defects. Carbonate apatite and type I atelocollagen mixture (CAp) was grafted on a porous poly-L-lactic acid (PLLA) membrane to produce a CAp bilayered PLLA membrane (CAp+PLLA). After implantation, region...
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| Veröffentlicht in: | Tissue engineering 2003-08, Vol.9 (4), p.635-643 |
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| creator | Suh, Hwal Song, Min Jung Ohata, Makoto Kang, Yu-Bong Tsutsumi, Sadami |
| description | Appropriate mechanical recovery is an important parameter in successful restoration of skeletal defects. Carbonate apatite and type I atelocollagen mixture (CAp) was grafted on a porous poly-L-lactic acid
(PLLA) membrane to produce a CAp bilayered PLLA membrane (CAp+PLLA). After implantation, regional mechanical change in the membrane was investigated in rabbit calvarial bone defects. Dynamic viscoelasticity
and elastic modulus of the implanted specimen were measured after 2, 4, 8, 12, 16, 26, and 52 weeks. The modulus of the peripheral part was higher than that of the central part of the implanted area, whereas
the central part demonstrated a gradual increase. This phenomenon indicates that regeneration initially occurs from the periphery of the calvarial bone. After 26 weeks, stiffness of the central part became
similar to that of the periphery in the CAp + PLLA-implanted area. According to this result, measuring viscoelasticity of an implanted biodegradable material would be a useful method to determine degrees
of regeneration and replacement of an implanted region. |
| doi_str_mv | 10.1089/107632703768247331 |
| format | Article |
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(PLLA) membrane to produce a CAp bilayered PLLA membrane (CAp+PLLA). After implantation, regional mechanical change in the membrane was investigated in rabbit calvarial bone defects. Dynamic viscoelasticity
and elastic modulus of the implanted specimen were measured after 2, 4, 8, 12, 16, 26, and 52 weeks. The modulus of the peripheral part was higher than that of the central part of the implanted area, whereas
the central part demonstrated a gradual increase. This phenomenon indicates that regeneration initially occurs from the periphery of the calvarial bone. After 26 weeks, stiffness of the central part became
similar to that of the periphery in the CAp + PLLA-implanted area. According to this result, measuring viscoelasticity of an implanted biodegradable material would be a useful method to determine degrees
of regeneration and replacement of an implanted region.</description><identifier>ISSN: 1076-3279</identifier><identifier>EISSN: 1557-8690</identifier><identifier>DOI: 10.1089/107632703768247331</identifier><identifier>PMID: 13678442</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Analysis of Variance ; Animals ; Apatites - metabolism ; Bone Substitutes - metabolism ; Collagen - metabolism ; Lactic Acid - metabolism ; Materials Testing ; Membranes, Artificial ; Microscopy, Electron, Scanning ; Original Articles ; poly(L-lactic acid) ; Polyesters ; Polymers - metabolism ; Rabbits ; Skull - metabolism</subject><ispartof>Tissue engineering, 2003-08, Vol.9 (4), p.635-643</ispartof><rights>Copyright Mary Ann Liebert Inc. Aug 2003</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-94e965cd6553d2127eb734fa1d9d3b084ad72f1f657416c7b0e61db18dd15f463</citedby><cites>FETCH-LOGICAL-c406t-94e965cd6553d2127eb734fa1d9d3b084ad72f1f657416c7b0e61db18dd15f463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.liebertpub.com/doi/epdf/10.1089/107632703768247331$$EPDF$$P50$$Gmaryannliebert$$H</linktopdf><linktohtml>$$Uhttps://www.liebertpub.com/doi/full/10.1089/107632703768247331$$EHTML$$P50$$Gmaryannliebert$$H</linktohtml><link.rule.ids>314,776,780,3029,21702,27901,27902,55266,55278</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13678442$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suh, Hwal</creatorcontrib><creatorcontrib>Song, Min Jung</creatorcontrib><creatorcontrib>Ohata, Makoto</creatorcontrib><creatorcontrib>Kang, Yu-Bong</creatorcontrib><creatorcontrib>Tsutsumi, Sadami</creatorcontrib><title>Ex Vivo Mechanical Evaluation of Carbonate Apatite-Collagen-Grafted Porous Poly-L-lactic Acid Membrane in Rabbit Calvarial Bone</title><title>Tissue engineering</title><addtitle>Tissue Eng</addtitle><description>Appropriate mechanical recovery is an important parameter in successful restoration of skeletal defects. Carbonate apatite and type I atelocollagen mixture (CAp) was grafted on a porous poly-L-lactic acid
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and elastic modulus of the implanted specimen were measured after 2, 4, 8, 12, 16, 26, and 52 weeks. The modulus of the peripheral part was higher than that of the central part of the implanted area, whereas
the central part demonstrated a gradual increase. This phenomenon indicates that regeneration initially occurs from the periphery of the calvarial bone. After 26 weeks, stiffness of the central part became
similar to that of the periphery in the CAp + PLLA-implanted area. According to this result, measuring viscoelasticity of an implanted biodegradable material would be a useful method to determine degrees
of regeneration and replacement of an implanted region.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Apatites - metabolism</subject><subject>Bone Substitutes - metabolism</subject><subject>Collagen - metabolism</subject><subject>Lactic Acid - metabolism</subject><subject>Materials Testing</subject><subject>Membranes, Artificial</subject><subject>Microscopy, Electron, Scanning</subject><subject>Original Articles</subject><subject>poly(L-lactic acid)</subject><subject>Polyesters</subject><subject>Polymers - metabolism</subject><subject>Rabbits</subject><subject>Skull - metabolism</subject><issn>1076-3279</issn><issn>1557-8690</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU2LFDEQhoMo7rr6BzxI8LC3rEnnq_s4DuMqjCiiXpt8VGuWTDKm04N78q-bZQaE9aCnCsVTT1J5EXrO6BWj_fCKUa14pynXqu-E5pw9QOdMSk16NdCH7dwA0ojhDD2Z5xtKqZRMP0ZnjCvdC9Gdo1-bn_hrOGT8Htx3k4IzEW8OJi6mhpxwnvDaFJuTqYBX-9asQNY5RvMNErkuZqrg8cdc8jK3Em_JlkTjanB45YJv1p0tJgEOCX8y1obafPFgSmj3vM4JnqJHk4kzPDvVC_Tlzebz-i3Zfrh-t15tiRNUVTIIGJR0XknJfcc6DVZzMRnmB88t7YXxupvYpKQWTDltKSjmLeu9Z3ISil-gy6N3X_KPBeY67sLsoC2SoL191FzJ9j_6nyDrB6Wo4g18eQ-8yUtJbYmxY1IxSZVsUHeEXMnzXGAa9yXsTLkdGR3vQhz_DrENvTiZF7sD_2fklFoD-iNw1zYpxQAWSv0f92_8tqcn</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Suh, Hwal</creator><creator>Song, Min Jung</creator><creator>Ohata, Makoto</creator><creator>Kang, Yu-Bong</creator><creator>Tsutsumi, Sadami</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20030801</creationdate><title>Ex Vivo Mechanical Evaluation of Carbonate Apatite-Collagen-Grafted Porous Poly-L-lactic Acid Membrane in Rabbit Calvarial Bone</title><author>Suh, Hwal ; 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Carbonate apatite and type I atelocollagen mixture (CAp) was grafted on a porous poly-L-lactic acid
(PLLA) membrane to produce a CAp bilayered PLLA membrane (CAp+PLLA). After implantation, regional mechanical change in the membrane was investigated in rabbit calvarial bone defects. Dynamic viscoelasticity
and elastic modulus of the implanted specimen were measured after 2, 4, 8, 12, 16, 26, and 52 weeks. The modulus of the peripheral part was higher than that of the central part of the implanted area, whereas
the central part demonstrated a gradual increase. This phenomenon indicates that regeneration initially occurs from the periphery of the calvarial bone. After 26 weeks, stiffness of the central part became
similar to that of the periphery in the CAp + PLLA-implanted area. According to this result, measuring viscoelasticity of an implanted biodegradable material would be a useful method to determine degrees
of regeneration and replacement of an implanted region.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>13678442</pmid><doi>10.1089/107632703768247331</doi><tpages>9</tpages></addata></record> |
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| subjects | Analysis of Variance Animals Apatites - metabolism Bone Substitutes - metabolism Collagen - metabolism Lactic Acid - metabolism Materials Testing Membranes, Artificial Microscopy, Electron, Scanning Original Articles poly(L-lactic acid) Polyesters Polymers - metabolism Rabbits Skull - metabolism |
| title | Ex Vivo Mechanical Evaluation of Carbonate Apatite-Collagen-Grafted Porous Poly-L-lactic Acid Membrane in Rabbit Calvarial Bone |
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