Animal models of ocular allergy
PURPOSE OF REVIEWThis review focuses on reports on animal models of ocular allergy published within the past year. A number of animal models are currently being used to clarify the pathophysiology of ocular allergy and to improve the therapeutic interventions for this disease. RECENT FINDINGSPublish...
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| Veröffentlicht in: | Current opinion in allergy and clinical immunology 2003-10, Vol.3 (5), p.375-379 |
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| container_title | Current opinion in allergy and clinical immunology |
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| creator | Bundoc, Virgilio G Keane-Myers, Andrea |
| description | PURPOSE OF REVIEWThis review focuses on reports on animal models of ocular allergy published within the past year. A number of animal models are currently being used to clarify the pathophysiology of ocular allergy and to improve the therapeutic interventions for this disease.
RECENT FINDINGSPublished literature examined the role of cytokines and other effector molecules which drive the immunopathology of ocular allergies in several animal models. Animal models were also used to compare the safety and efficacy of currently available drugs, and were utilized in initial trials of novel therapeutic agents. Novel therapeutic options being studied include DNA immunizations and recombinant peptides that block enzymes involved in the inflammatory processes.
SUMMARYSeveral animal models are currently being used in the study of ocular allergy. These include different strains within the mouse, rat, guinea pig, rabbit and dog species. Continuing investigations are needed to elucidate the complex molecular and cellular processes involved in the pathogenesis of ocular allergies. A better understanding of the interplay of effector cells, cytokines, adhesion molecules and a number of other inflammatory mediators will broaden our knowledge of the pathophysiology of ocular allergy and allow improved therapeutic options for this disease. |
| doi_str_mv | 10.1097/00130832-200310000-00010 |
| format | Article |
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RECENT FINDINGSPublished literature examined the role of cytokines and other effector molecules which drive the immunopathology of ocular allergies in several animal models. Animal models were also used to compare the safety and efficacy of currently available drugs, and were utilized in initial trials of novel therapeutic agents. Novel therapeutic options being studied include DNA immunizations and recombinant peptides that block enzymes involved in the inflammatory processes.
SUMMARYSeveral animal models are currently being used in the study of ocular allergy. These include different strains within the mouse, rat, guinea pig, rabbit and dog species. Continuing investigations are needed to elucidate the complex molecular and cellular processes involved in the pathogenesis of ocular allergies. A better understanding of the interplay of effector cells, cytokines, adhesion molecules and a number of other inflammatory mediators will broaden our knowledge of the pathophysiology of ocular allergy and allow improved therapeutic options for this disease.</description><identifier>ISSN: 1528-4050</identifier><identifier>EISSN: 1473-6322</identifier><identifier>DOI: 10.1097/00130832-200310000-00010</identifier><identifier>PMID: 14501438</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins, Inc</publisher><subject>Animals ; Dogs ; Eye Diseases - drug therapy ; Eye Diseases - immunology ; Eye Diseases - physiopathology ; Guinea Pigs ; Humans ; Hypersensitivity - complications ; Hypersensitivity - drug therapy ; Hypersensitivity - physiopathology ; Mice ; Models, Animal ; Rabbits ; Rats</subject><ispartof>Current opinion in allergy and clinical immunology, 2003-10, Vol.3 (5), p.375-379</ispartof><rights>2003 Lippincott Williams & Wilkins, Inc.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2710-197a2d31dee03597425cae3c579c382a3e03ae620d2c819ff41aaec357cd1db53</citedby><cites>FETCH-LOGICAL-c2710-197a2d31dee03597425cae3c579c382a3e03ae620d2c819ff41aaec357cd1db53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14501438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bundoc, Virgilio G</creatorcontrib><creatorcontrib>Keane-Myers, Andrea</creatorcontrib><title>Animal models of ocular allergy</title><title>Current opinion in allergy and clinical immunology</title><addtitle>Curr Opin Allergy Clin Immunol</addtitle><description>PURPOSE OF REVIEWThis review focuses on reports on animal models of ocular allergy published within the past year. A number of animal models are currently being used to clarify the pathophysiology of ocular allergy and to improve the therapeutic interventions for this disease.
RECENT FINDINGSPublished literature examined the role of cytokines and other effector molecules which drive the immunopathology of ocular allergies in several animal models. Animal models were also used to compare the safety and efficacy of currently available drugs, and were utilized in initial trials of novel therapeutic agents. Novel therapeutic options being studied include DNA immunizations and recombinant peptides that block enzymes involved in the inflammatory processes.
SUMMARYSeveral animal models are currently being used in the study of ocular allergy. These include different strains within the mouse, rat, guinea pig, rabbit and dog species. Continuing investigations are needed to elucidate the complex molecular and cellular processes involved in the pathogenesis of ocular allergies. A better understanding of the interplay of effector cells, cytokines, adhesion molecules and a number of other inflammatory mediators will broaden our knowledge of the pathophysiology of ocular allergy and allow improved therapeutic options for this disease.</description><subject>Animals</subject><subject>Dogs</subject><subject>Eye Diseases - drug therapy</subject><subject>Eye Diseases - immunology</subject><subject>Eye Diseases - physiopathology</subject><subject>Guinea Pigs</subject><subject>Humans</subject><subject>Hypersensitivity - complications</subject><subject>Hypersensitivity - drug therapy</subject><subject>Hypersensitivity - physiopathology</subject><subject>Mice</subject><subject>Models, Animal</subject><subject>Rabbits</subject><subject>Rats</subject><issn>1528-4050</issn><issn>1473-6322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLAzEQgIMoVqt_QffkLTqTR7N7LMUXFLzoOaTZWVvNdmvSpfTfG23Vk4GQIXzz-hgrEK4RKnMDgBJKKbgAkAj58HwRDtgJKiP5SApxmGMtSq5Aw4CdpvSWCVGBOGYDVBpQyfKEXY6Xi9aFou1qCqnomqLzfXCxcCFQfN2esaPGhUTn-3fIXu5unycPfPp0_zgZT7kXBoFjZZyoJdZEIHVllNDekfTaVF6Wwsn87WgkoBa-xKppFDpHXmrja6xnWg7Z1a7uKnYfPaW1bRfJUwhuSV2frJEjVeXpM1juQB-7lCI1dhXzBnFrEeyXHPsjx_7Ksd9ycurFvkc_a6n-S9zbyIDaAZsurCmm99BvKNo5ubCe2_-ky0-Dz2yM</recordid><startdate>200310</startdate><enddate>200310</enddate><creator>Bundoc, Virgilio G</creator><creator>Keane-Myers, Andrea</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200310</creationdate><title>Animal models of ocular allergy</title><author>Bundoc, Virgilio G ; Keane-Myers, Andrea</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2710-197a2d31dee03597425cae3c579c382a3e03ae620d2c819ff41aaec357cd1db53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Dogs</topic><topic>Eye Diseases - drug therapy</topic><topic>Eye Diseases - immunology</topic><topic>Eye Diseases - physiopathology</topic><topic>Guinea Pigs</topic><topic>Humans</topic><topic>Hypersensitivity - complications</topic><topic>Hypersensitivity - drug therapy</topic><topic>Hypersensitivity - physiopathology</topic><topic>Mice</topic><topic>Models, Animal</topic><topic>Rabbits</topic><topic>Rats</topic><toplevel>online_resources</toplevel><creatorcontrib>Bundoc, Virgilio G</creatorcontrib><creatorcontrib>Keane-Myers, Andrea</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current opinion in allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bundoc, Virgilio G</au><au>Keane-Myers, Andrea</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Animal models of ocular allergy</atitle><jtitle>Current opinion in allergy and clinical immunology</jtitle><addtitle>Curr Opin Allergy Clin Immunol</addtitle><date>2003-10</date><risdate>2003</risdate><volume>3</volume><issue>5</issue><spage>375</spage><epage>379</epage><pages>375-379</pages><issn>1528-4050</issn><eissn>1473-6322</eissn><abstract>PURPOSE OF REVIEWThis review focuses on reports on animal models of ocular allergy published within the past year. A number of animal models are currently being used to clarify the pathophysiology of ocular allergy and to improve the therapeutic interventions for this disease.
RECENT FINDINGSPublished literature examined the role of cytokines and other effector molecules which drive the immunopathology of ocular allergies in several animal models. Animal models were also used to compare the safety and efficacy of currently available drugs, and were utilized in initial trials of novel therapeutic agents. Novel therapeutic options being studied include DNA immunizations and recombinant peptides that block enzymes involved in the inflammatory processes.
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| ispartof | Current opinion in allergy and clinical immunology, 2003-10, Vol.3 (5), p.375-379 |
| issn | 1528-4050 1473-6322 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Dogs Eye Diseases - drug therapy Eye Diseases - immunology Eye Diseases - physiopathology Guinea Pigs Humans Hypersensitivity - complications Hypersensitivity - drug therapy Hypersensitivity - physiopathology Mice Models, Animal Rabbits Rats |
| title | Animal models of ocular allergy |
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