Heart Imaging with Cationic Complexes of Technetium
The cationic technetium-99 complex trans-[$^{99}$TC(dmpe)$_{2}$Cl$_{2}$]$^{+}$, where dmpe is bis(1,2-dimethylphosphino)ethane or (CH$_{3}$)$_{2}$P-CH$_{2}$CH$_{2}$-P(CH$_{3}$)$_{2}$, has been prepared and characterized by single-crystal, x-ray structural analysis. The technetium-99m analog, trans-[...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1981-10, Vol.214 (4516), p.85-86 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Deutsch, Edward Bushong, William Glavan, Kenneth A. Elder, R. C. Sodd, Vincent J. Scholz, Kenneth L. Fortman, Donald L. Lukes, Steven J. |
| description | The cationic technetium-99 complex trans-[$^{99}$TC(dmpe)$_{2}$Cl$_{2}$]$^{+}$, where dmpe is bis(1,2-dimethylphosphino)ethane or (CH$_{3}$)$_{2}$P-CH$_{2}$CH$_{2}$-P(CH$_{3}$)$_{2}$, has been prepared and characterized by single-crystal, x-ray structural analysis. The technetium-99m analog, trans-[$^{99\text{m}}$Tc(dmpe) $_{2}$Cl$_{2}$]$^{+}$, has also been prepared and shown to yield excellent gamma-ray images of the heart. The purposeful design, characterization, and synthesis of this technetium-99m radiopharmaceutical represents a striking application of fundamental inorganic chemistry to a problem in applied nuclear medicine. |
| doi_str_mv | 10.1126/science.6897930 |
| format | Article |
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C. ; Sodd, Vincent J. ; Scholz, Kenneth L. ; Fortman, Donald L. ; Lukes, Steven J.</creator><creatorcontrib>Deutsch, Edward ; Bushong, William ; Glavan, Kenneth A. ; Elder, R. C. ; Sodd, Vincent J. ; Scholz, Kenneth L. ; Fortman, Donald L. ; Lukes, Steven J.</creatorcontrib><description>The cationic technetium-99 complex trans-[$^{99}$TC(dmpe)$_{2}$Cl$_{2}$]$^{+}$, where dmpe is bis(1,2-dimethylphosphino)ethane or (CH$_{3}$)$_{2}$P-CH$_{2}$CH$_{2}$-P(CH$_{3}$)$_{2}$, has been prepared and characterized by single-crystal, x-ray structural analysis. The technetium-99m analog, trans-[$^{99\text{m}}$Tc(dmpe) $_{2}$Cl$_{2}$]$^{+}$, has also been prepared and shown to yield excellent gamma-ray images of the heart. The purposeful design, characterization, and synthesis of this technetium-99m radiopharmaceutical represents a striking application of fundamental inorganic chemistry to a problem in applied nuclear medicine.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.6897930</identifier><identifier>PMID: 6897930</identifier><language>eng</language><publisher>United States: The American Association for the Advancement Science</publisher><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics ; Animals ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; Birds ; Blood ; BODY ; CARDIOGRAPHY ; CARDIOVASCULAR DISEASES ; CARDIOVASCULAR SYSTEM ; CATIONS ; Cations, Monovalent ; CHARGED PARTICLES ; CHEMICAL PREPARATION ; COMPLEXES ; DIAGNOSIS ; DIAGNOSTIC TECHNIQUES ; DISEASES ; Dogs ; DRUGS ; Gamma rays ; HEART ; Heart - diagnostic imaging ; HOURS LIVING RADIOISOTOPES ; Imaging ; INTERMEDIATE MASS NUCLEI ; IONS ; ISOMERIC NUCLEI ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPES ; LABELLED COMPOUNDS ; Ligands ; Liver ; MEASURING METHODS ; MEDICINE ; Myocardium ; NUCLEAR MEDICINE ; NUCLEI ; ODD-EVEN NUCLEI ; Organotechnetium Compounds ; ORGANS ; Phosphines ; RADIOCARDIOGRAPHY ; RADIOISOTOPES ; RADIOLOGY AND NUCLEAR MEDICINE ; Radionuclide Imaging ; RADIOPHARMACEUTICALS ; Structure-Activity Relationship ; SYNTHESIS ; Technetium ; TECHNETIUM 99 ; TECHNETIUM COMPLEXES ; TECHNETIUM ISOTOPES ; TRANSITION ELEMENT COMPLEXES ; UPTAKE ; YEARS LIVING RADIOISOTOPES</subject><ispartof>Science (American Association for the Advancement of Science), 1981-10, Vol.214 (4516), p.85-86</ispartof><rights>Copyright 1981 The American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-fa64c70df9214e88c5fb3bde3baf179ffa0da55000a3eb9ea1ec8355ea810abe3</citedby><cites>FETCH-LOGICAL-c369t-fa64c70df9214e88c5fb3bde3baf179ffa0da55000a3eb9ea1ec8355ea810abe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1687270$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1687270$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,885,2882,2883,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6897930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5800889$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Deutsch, Edward</creatorcontrib><creatorcontrib>Bushong, William</creatorcontrib><creatorcontrib>Glavan, Kenneth A.</creatorcontrib><creatorcontrib>Elder, R. C.</creatorcontrib><creatorcontrib>Sodd, Vincent J.</creatorcontrib><creatorcontrib>Scholz, Kenneth L.</creatorcontrib><creatorcontrib>Fortman, Donald L.</creatorcontrib><creatorcontrib>Lukes, Steven J.</creatorcontrib><title>Heart Imaging with Cationic Complexes of Technetium</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The cationic technetium-99 complex trans-[$^{99}$TC(dmpe)$_{2}$Cl$_{2}$]$^{+}$, where dmpe is bis(1,2-dimethylphosphino)ethane or (CH$_{3}$)$_{2}$P-CH$_{2}$CH$_{2}$-P(CH$_{3}$)$_{2}$, has been prepared and characterized by single-crystal, x-ray structural analysis. The technetium-99m analog, trans-[$^{99\text{m}}$Tc(dmpe) $_{2}$Cl$_{2}$]$^{+}$, has also been prepared and shown to yield excellent gamma-ray images of the heart. The purposeful design, characterization, and synthesis of this technetium-99m radiopharmaceutical represents a striking application of fundamental inorganic chemistry to a problem in applied nuclear medicine.</description><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics</subject><subject>Animals</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>Birds</subject><subject>Blood</subject><subject>BODY</subject><subject>CARDIOGRAPHY</subject><subject>CARDIOVASCULAR DISEASES</subject><subject>CARDIOVASCULAR SYSTEM</subject><subject>CATIONS</subject><subject>Cations, Monovalent</subject><subject>CHARGED PARTICLES</subject><subject>CHEMICAL PREPARATION</subject><subject>COMPLEXES</subject><subject>DIAGNOSIS</subject><subject>DIAGNOSTIC TECHNIQUES</subject><subject>DISEASES</subject><subject>Dogs</subject><subject>DRUGS</subject><subject>Gamma rays</subject><subject>HEART</subject><subject>Heart - diagnostic imaging</subject><subject>HOURS LIVING RADIOISOTOPES</subject><subject>Imaging</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>IONS</subject><subject>ISOMERIC NUCLEI</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPES</subject><subject>LABELLED COMPOUNDS</subject><subject>Ligands</subject><subject>Liver</subject><subject>MEASURING METHODS</subject><subject>MEDICINE</subject><subject>Myocardium</subject><subject>NUCLEAR MEDICINE</subject><subject>NUCLEI</subject><subject>ODD-EVEN NUCLEI</subject><subject>Organotechnetium Compounds</subject><subject>ORGANS</subject><subject>Phosphines</subject><subject>RADIOCARDIOGRAPHY</subject><subject>RADIOISOTOPES</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radionuclide Imaging</subject><subject>RADIOPHARMACEUTICALS</subject><subject>Structure-Activity Relationship</subject><subject>SYNTHESIS</subject><subject>Technetium</subject><subject>TECHNETIUM 99</subject><subject>TECHNETIUM COMPLEXES</subject><subject>TECHNETIUM ISOTOPES</subject><subject>TRANSITION ELEMENT COMPLEXES</subject><subject>UPTAKE</subject><subject>YEARS LIVING RADIOISOTOPES</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkDFPwzAUhC0EKqUws4AUMbClfY6bxB5RBLRSJZYyW47z3LpK4hK7Av49QYlgesN9d7p3hNxSmFOaZAuvLbYa5xkXuWBwRqYURBqLBNg5mQKwLOaQp5fkyvsDQK8JNiGTEZ8StkLVhWjdqJ1td9GnDfuoUMG61uqocM2xxi_0kTPRFvW-xWBPzTW5MKr2eDPeGXl_ed4Wq3jz9rounjaxZpkIsVHZUudQGZHQJXKuU1OyskJWKkNzYYyCSqVpX0oxLAUqipqzNEXFKagS2Yw8DLnOByv7T0NfQbu2RR1kygE4Fz30OEDHzn2c0AfZWK-xrlWL7uRlzrKlAJ704GIAdee879DIY2cb1X1LCvJ3SzluKcdxesf9GH0qG6z--H_9btAPPrjuPy7jeZID-wGdmnpG</recordid><startdate>19811002</startdate><enddate>19811002</enddate><creator>Deutsch, Edward</creator><creator>Bushong, William</creator><creator>Glavan, Kenneth A.</creator><creator>Elder, R. C.</creator><creator>Sodd, Vincent J.</creator><creator>Scholz, Kenneth L.</creator><creator>Fortman, Donald L.</creator><creator>Lukes, Steven J.</creator><general>The American Association for the Advancement Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19811002</creationdate><title>Heart Imaging with Cationic Complexes of Technetium</title><author>Deutsch, Edward ; Bushong, William ; Glavan, Kenneth A. ; Elder, R. C. ; Sodd, Vincent J. ; Scholz, Kenneth L. ; Fortman, Donald L. ; Lukes, Steven J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-fa64c70df9214e88c5fb3bde3baf179ffa0da55000a3eb9ea1ec8355ea810abe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>550601 - Medicine- Unsealed Radionuclides in Diagnostics</topic><topic>Animals</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>Birds</topic><topic>Blood</topic><topic>BODY</topic><topic>CARDIOGRAPHY</topic><topic>CARDIOVASCULAR DISEASES</topic><topic>CARDIOVASCULAR SYSTEM</topic><topic>CATIONS</topic><topic>Cations, Monovalent</topic><topic>CHARGED PARTICLES</topic><topic>CHEMICAL PREPARATION</topic><topic>COMPLEXES</topic><topic>DIAGNOSIS</topic><topic>DIAGNOSTIC TECHNIQUES</topic><topic>DISEASES</topic><topic>Dogs</topic><topic>DRUGS</topic><topic>Gamma rays</topic><topic>HEART</topic><topic>Heart - diagnostic imaging</topic><topic>HOURS LIVING RADIOISOTOPES</topic><topic>Imaging</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>IONS</topic><topic>ISOMERIC NUCLEI</topic><topic>ISOMERIC TRANSITION ISOTOPES</topic><topic>ISOTOPES</topic><topic>LABELLED COMPOUNDS</topic><topic>Ligands</topic><topic>Liver</topic><topic>MEASURING METHODS</topic><topic>MEDICINE</topic><topic>Myocardium</topic><topic>NUCLEAR MEDICINE</topic><topic>NUCLEI</topic><topic>ODD-EVEN NUCLEI</topic><topic>Organotechnetium Compounds</topic><topic>ORGANS</topic><topic>Phosphines</topic><topic>RADIOCARDIOGRAPHY</topic><topic>RADIOISOTOPES</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Radionuclide Imaging</topic><topic>RADIOPHARMACEUTICALS</topic><topic>Structure-Activity Relationship</topic><topic>SYNTHESIS</topic><topic>Technetium</topic><topic>TECHNETIUM 99</topic><topic>TECHNETIUM COMPLEXES</topic><topic>TECHNETIUM ISOTOPES</topic><topic>TRANSITION ELEMENT COMPLEXES</topic><topic>UPTAKE</topic><topic>YEARS LIVING RADIOISOTOPES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deutsch, Edward</creatorcontrib><creatorcontrib>Bushong, William</creatorcontrib><creatorcontrib>Glavan, Kenneth A.</creatorcontrib><creatorcontrib>Elder, R. C.</creatorcontrib><creatorcontrib>Sodd, Vincent J.</creatorcontrib><creatorcontrib>Scholz, Kenneth L.</creatorcontrib><creatorcontrib>Fortman, Donald L.</creatorcontrib><creatorcontrib>Lukes, Steven J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deutsch, Edward</au><au>Bushong, William</au><au>Glavan, Kenneth A.</au><au>Elder, R. C.</au><au>Sodd, Vincent J.</au><au>Scholz, Kenneth L.</au><au>Fortman, Donald L.</au><au>Lukes, Steven J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heart Imaging with Cationic Complexes of Technetium</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1981-10-02</date><risdate>1981</risdate><volume>214</volume><issue>4516</issue><spage>85</spage><epage>86</epage><pages>85-86</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>The cationic technetium-99 complex trans-[$^{99}$TC(dmpe)$_{2}$Cl$_{2}$]$^{+}$, where dmpe is bis(1,2-dimethylphosphino)ethane or (CH$_{3}$)$_{2}$P-CH$_{2}$CH$_{2}$-P(CH$_{3}$)$_{2}$, has been prepared and characterized by single-crystal, x-ray structural analysis. The technetium-99m analog, trans-[$^{99\text{m}}$Tc(dmpe) $_{2}$Cl$_{2}$]$^{+}$, has also been prepared and shown to yield excellent gamma-ray images of the heart. The purposeful design, characterization, and synthesis of this technetium-99m radiopharmaceutical represents a striking application of fundamental inorganic chemistry to a problem in applied nuclear medicine.</abstract><cop>United States</cop><pub>The American Association for the Advancement Science</pub><pmid>6897930</pmid><doi>10.1126/science.6897930</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1981-10, Vol.214 (4516), p.85-86 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73649082 |
| source | MEDLINE; Science Magazine; JSTOR Archive Collection A-Z Listing |
| subjects | 550601 - Medicine- Unsealed Radionuclides in Diagnostics Animals BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Birds Blood BODY CARDIOGRAPHY CARDIOVASCULAR DISEASES CARDIOVASCULAR SYSTEM CATIONS Cations, Monovalent CHARGED PARTICLES CHEMICAL PREPARATION COMPLEXES DIAGNOSIS DIAGNOSTIC TECHNIQUES DISEASES Dogs DRUGS Gamma rays HEART Heart - diagnostic imaging HOURS LIVING RADIOISOTOPES Imaging INTERMEDIATE MASS NUCLEI IONS ISOMERIC NUCLEI ISOMERIC TRANSITION ISOTOPES ISOTOPES LABELLED COMPOUNDS Ligands Liver MEASURING METHODS MEDICINE Myocardium NUCLEAR MEDICINE NUCLEI ODD-EVEN NUCLEI Organotechnetium Compounds ORGANS Phosphines RADIOCARDIOGRAPHY RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE Radionuclide Imaging RADIOPHARMACEUTICALS Structure-Activity Relationship SYNTHESIS Technetium TECHNETIUM 99 TECHNETIUM COMPLEXES TECHNETIUM ISOTOPES TRANSITION ELEMENT COMPLEXES UPTAKE YEARS LIVING RADIOISOTOPES |
| title | Heart Imaging with Cationic Complexes of Technetium |
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