Vitamin B6-mediated suppression of colon tumorigenesis, cell proliferation, and angiogenesis (review)
This review describes current research on the preventive effect of dietary vitamin B(6) against colon tumorigenesis and its possible mechanisms. Studies in cell culture have demonstrated that high levels of vitamin B(6) suppress growth of some cancer cells. From these studies it has been considered...
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| Veröffentlicht in: | The Journal of nutritional biochemistry 2003-05, Vol.14 (5), p.246-250 |
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| container_title | The Journal of nutritional biochemistry |
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| creator | MATSUBARA, Kiminori KOMATSU, Shun-Ichiro OKA, Tatsuzo KATO, Norihisa |
| description | This review describes current research on the preventive effect of dietary vitamin B(6) against colon tumorigenesis and its possible mechanisms. Studies in cell culture have demonstrated that high levels of vitamin B(6) suppress growth of some cancer cells. From these studies it has been considered that supraphysiological doses of vitamin B(6) suppress tumor growth and metastasis. However, recent rodent study has indicated that azoxymethane-induced colon tumorigenesis in mice is suppressed by moderate doses of dietary vitamin B(6.) Epidemiological studies also support an inverse relationship between vitamin B(6) intake and colon cancer risk. Potential mechanisms underlying the preventive effect of dietary vitamin B(6) have been suggested to include the suppression of cell proliferation, oxidative stress, nitric oxide (NO) synthesis, and angiogenesis. |
| doi_str_mv | 10.1016/s0955-2863(03)00009-3 |
| format | Article |
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Studies in cell culture have demonstrated that high levels of vitamin B(6) suppress growth of some cancer cells. From these studies it has been considered that supraphysiological doses of vitamin B(6) suppress tumor growth and metastasis. However, recent rodent study has indicated that azoxymethane-induced colon tumorigenesis in mice is suppressed by moderate doses of dietary vitamin B(6.) Epidemiological studies also support an inverse relationship between vitamin B(6) intake and colon cancer risk. 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Studies in cell culture have demonstrated that high levels of vitamin B(6) suppress growth of some cancer cells. From these studies it has been considered that supraphysiological doses of vitamin B(6) suppress tumor growth and metastasis. However, recent rodent study has indicated that azoxymethane-induced colon tumorigenesis in mice is suppressed by moderate doses of dietary vitamin B(6.) Epidemiological studies also support an inverse relationship between vitamin B(6) intake and colon cancer risk. 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| ispartof | The Journal of nutritional biochemistry, 2003-05, Vol.14 (5), p.246-250 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cell Division - drug effects Colonic Neoplasms - prevention & control Diet Foods and miscellaneous Humans Medical sciences Mice Neovascularization, Physiologic - drug effects Nitric Oxide Oxidative Stress Tumors Vitamin B 6 - administration & dosage |
| title | Vitamin B6-mediated suppression of colon tumorigenesis, cell proliferation, and angiogenesis (review) |
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