Contribution of β-2 microglobulin levels to the prognostic stratification of survival in patients with myelodysplastic syndrome (MDS)
Prospective analysis of the importance of the plasma levels of β-2 microglobulin (B2M) in 553 patients with myelodysplastic syndrome (MDS) found that B2M is an independent prognostic variable for survival with weighted significance second only to the karyotype. The incorporation of the B2M covariate...
Gespeichert in:
| Veröffentlicht in: | Blood 2003-09, Vol.102 (5), p.1622-1625 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1625 |
|---|---|
| container_issue | 5 |
| container_start_page | 1622 |
| container_title | Blood |
| container_volume | 102 |
| creator | Gatto, Simona Ball, Greg Onida, Francesco Kantarjian, Hagop M. Estey, Elihu H. Beran, Miloslav |
| description | Prospective analysis of the importance of the plasma levels of β-2 microglobulin (B2M) in 553 patients with myelodysplastic syndrome (MDS) found that B2M is an independent prognostic variable for survival with weighted significance second only to the karyotype. The incorporation of the B2M covariate into risk assessment of MDS patients added significantly to the power of the IPSS to stratify MDS patients into risk categories. Our results further document that the 2 objectively measured covariates that display the highest power to predict survival, that is, karyotype and B2M, can alone be used for risk stratification. While the results must be verified in an independent and comparable population, our data strongly recommend routine measurement of B2M in patients with MDS. |
| doi_str_mv | 10.1182/blood-2002-10-3264 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73647447</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006497120441436</els_id><sourcerecordid>73647447</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-35be53b7ca924c021a527531618946eb03c60824604f36c814d24dcbc830ff073</originalsourceid><addsrcrecordid>eNp9kE1uFDEQRi0EIpPABVggb0BhYfBf2z1SNmiABCmIBbC23O5qYuRuD7Z70FwgB-IgnAk3Myi7rEr66n0l-yH0jNHXjLX8TRdi7AmnlBNGieBKPkAr1vCW1Ig-RCtKqSJyrdkJOs35B6VMCt48RieMa9EqrVfodhOnknw3Fx8nHAf85zfhePQuxe8hdnPwEw6wg5BxibjcAN7WzRRz8Q7nkmzxg3f2fzvPaed3NuBa29YUppLxL19u8LiHEPt93gZ76O6nPsUR8Pmnd19ePUGPBhsyPD3OM_Ttw_uvmyty_fny4-btNXGSq0JE00EjOu3smktHObMN141girVrqaCjwinacqmoHIRyLZM9l73rXCvoMFAtztDLw936i58z5GJGnx2EYCeIczZaKKmlXEB-AKuInBMMZpv8aNPeMGoW--affbPYX6LFfi09P16fuxH6u8pRdwVeHAGbnQ1DspPz-Y5raKul4pW7OHDVO-w8JJNddemg9wlcMX30973jL17YpTI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73647447</pqid></control><display><type>article</type><title>Contribution of β-2 microglobulin levels to the prognostic stratification of survival in patients with myelodysplastic syndrome (MDS)</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Gatto, Simona ; Ball, Greg ; Onida, Francesco ; Kantarjian, Hagop M. ; Estey, Elihu H. ; Beran, Miloslav</creator><creatorcontrib>Gatto, Simona ; Ball, Greg ; Onida, Francesco ; Kantarjian, Hagop M. ; Estey, Elihu H. ; Beran, Miloslav</creatorcontrib><description>Prospective analysis of the importance of the plasma levels of β-2 microglobulin (B2M) in 553 patients with myelodysplastic syndrome (MDS) found that B2M is an independent prognostic variable for survival with weighted significance second only to the karyotype. The incorporation of the B2M covariate into risk assessment of MDS patients added significantly to the power of the IPSS to stratify MDS patients into risk categories. Our results further document that the 2 objectively measured covariates that display the highest power to predict survival, that is, karyotype and B2M, can alone be used for risk stratification. While the results must be verified in an independent and comparable population, our data strongly recommend routine measurement of B2M in patients with MDS.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood-2002-10-3264</identifier><identifier>PMID: 12738677</identifier><language>eng</language><publisher>Washington, DC: Elsevier Inc</publisher><subject>beta 2-Microglobulin - blood ; Biological and medical sciences ; Female ; Hematologic and hematopoietic diseases ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Middle Aged ; Myelodysplastic Syndromes - blood ; Myelodysplastic Syndromes - diagnosis ; Myelodysplastic Syndromes - mortality ; Predictive Value of Tests ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Risk Factors ; Survival Analysis</subject><ispartof>Blood, 2003-09, Vol.102 (5), p.1622-1625</ispartof><rights>2003 American Society of Hematology</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-35be53b7ca924c021a527531618946eb03c60824604f36c814d24dcbc830ff073</citedby><cites>FETCH-LOGICAL-c426t-35be53b7ca924c021a527531618946eb03c60824604f36c814d24dcbc830ff073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15087462$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12738677$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gatto, Simona</creatorcontrib><creatorcontrib>Ball, Greg</creatorcontrib><creatorcontrib>Onida, Francesco</creatorcontrib><creatorcontrib>Kantarjian, Hagop M.</creatorcontrib><creatorcontrib>Estey, Elihu H.</creatorcontrib><creatorcontrib>Beran, Miloslav</creatorcontrib><title>Contribution of β-2 microglobulin levels to the prognostic stratification of survival in patients with myelodysplastic syndrome (MDS)</title><title>Blood</title><addtitle>Blood</addtitle><description>Prospective analysis of the importance of the plasma levels of β-2 microglobulin (B2M) in 553 patients with myelodysplastic syndrome (MDS) found that B2M is an independent prognostic variable for survival with weighted significance second only to the karyotype. The incorporation of the B2M covariate into risk assessment of MDS patients added significantly to the power of the IPSS to stratify MDS patients into risk categories. Our results further document that the 2 objectively measured covariates that display the highest power to predict survival, that is, karyotype and B2M, can alone be used for risk stratification. While the results must be verified in an independent and comparable population, our data strongly recommend routine measurement of B2M in patients with MDS.</description><subject>beta 2-Microglobulin - blood</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myelodysplastic Syndromes - blood</subject><subject>Myelodysplastic Syndromes - diagnosis</subject><subject>Myelodysplastic Syndromes - mortality</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Survival Analysis</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1uFDEQRi0EIpPABVggb0BhYfBf2z1SNmiABCmIBbC23O5qYuRuD7Z70FwgB-IgnAk3Myi7rEr66n0l-yH0jNHXjLX8TRdi7AmnlBNGieBKPkAr1vCW1Ig-RCtKqSJyrdkJOs35B6VMCt48RieMa9EqrVfodhOnknw3Fx8nHAf85zfhePQuxe8hdnPwEw6wg5BxibjcAN7WzRRz8Q7nkmzxg3f2fzvPaed3NuBa29YUppLxL19u8LiHEPt93gZ76O6nPsUR8Pmnd19ePUGPBhsyPD3OM_Ttw_uvmyty_fny4-btNXGSq0JE00EjOu3smktHObMN141girVrqaCjwinacqmoHIRyLZM9l73rXCvoMFAtztDLw936i58z5GJGnx2EYCeIczZaKKmlXEB-AKuInBMMZpv8aNPeMGoW--affbPYX6LFfi09P16fuxH6u8pRdwVeHAGbnQ1DspPz-Y5raKul4pW7OHDVO-w8JJNddemg9wlcMX30973jL17YpTI</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>Gatto, Simona</creator><creator>Ball, Greg</creator><creator>Onida, Francesco</creator><creator>Kantarjian, Hagop M.</creator><creator>Estey, Elihu H.</creator><creator>Beran, Miloslav</creator><general>Elsevier Inc</general><general>The Americain Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030901</creationdate><title>Contribution of β-2 microglobulin levels to the prognostic stratification of survival in patients with myelodysplastic syndrome (MDS)</title><author>Gatto, Simona ; Ball, Greg ; Onida, Francesco ; Kantarjian, Hagop M. ; Estey, Elihu H. ; Beran, Miloslav</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-35be53b7ca924c021a527531618946eb03c60824604f36c814d24dcbc830ff073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>beta 2-Microglobulin - blood</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myelodysplastic Syndromes - blood</topic><topic>Myelodysplastic Syndromes - diagnosis</topic><topic>Myelodysplastic Syndromes - mortality</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gatto, Simona</creatorcontrib><creatorcontrib>Ball, Greg</creatorcontrib><creatorcontrib>Onida, Francesco</creatorcontrib><creatorcontrib>Kantarjian, Hagop M.</creatorcontrib><creatorcontrib>Estey, Elihu H.</creatorcontrib><creatorcontrib>Beran, Miloslav</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gatto, Simona</au><au>Ball, Greg</au><au>Onida, Francesco</au><au>Kantarjian, Hagop M.</au><au>Estey, Elihu H.</au><au>Beran, Miloslav</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contribution of β-2 microglobulin levels to the prognostic stratification of survival in patients with myelodysplastic syndrome (MDS)</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>2003-09-01</date><risdate>2003</risdate><volume>102</volume><issue>5</issue><spage>1622</spage><epage>1625</epage><pages>1622-1625</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Prospective analysis of the importance of the plasma levels of β-2 microglobulin (B2M) in 553 patients with myelodysplastic syndrome (MDS) found that B2M is an independent prognostic variable for survival with weighted significance second only to the karyotype. The incorporation of the B2M covariate into risk assessment of MDS patients added significantly to the power of the IPSS to stratify MDS patients into risk categories. Our results further document that the 2 objectively measured covariates that display the highest power to predict survival, that is, karyotype and B2M, can alone be used for risk stratification. While the results must be verified in an independent and comparable population, our data strongly recommend routine measurement of B2M in patients with MDS.</abstract><cop>Washington, DC</cop><pub>Elsevier Inc</pub><pmid>12738677</pmid><doi>10.1182/blood-2002-10-3264</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-4971 |
| ispartof | Blood, 2003-09, Vol.102 (5), p.1622-1625 |
| issn | 0006-4971 1528-0020 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73647447 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | beta 2-Microglobulin - blood Biological and medical sciences Female Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Myelodysplastic Syndromes - blood Myelodysplastic Syndromes - diagnosis Myelodysplastic Syndromes - mortality Predictive Value of Tests Prognosis Proportional Hazards Models Prospective Studies Risk Factors Survival Analysis |
| title | Contribution of β-2 microglobulin levels to the prognostic stratification of survival in patients with myelodysplastic syndrome (MDS) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T05%3A46%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Contribution%20of%20%CE%B2-2%20microglobulin%20levels%20to%20the%20prognostic%20stratification%20of%20survival%20in%20patients%20with%20myelodysplastic%20syndrome%20(MDS)&rft.jtitle=Blood&rft.au=Gatto,%20Simona&rft.date=2003-09-01&rft.volume=102&rft.issue=5&rft.spage=1622&rft.epage=1625&rft.pages=1622-1625&rft.issn=0006-4971&rft.eissn=1528-0020&rft_id=info:doi/10.1182/blood-2002-10-3264&rft_dat=%3Cproquest_cross%3E73647447%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73647447&rft_id=info:pmid/12738677&rft_els_id=S0006497120441436&rfr_iscdi=true |