siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells

The targeted inhibition of antiapoptotic factors in tumour cells may provide a rational approach towards the development of novel anticancer therapies. Using human papillomavirus (HPV)-transformed cells as a model system, we investigated if RNA interference (RNAi)-mediated gene silencing can be empl...

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Veröffentlicht in:	Oncogene 2003-09, Vol.22 (38), p.5938-5945
Hauptverfasser:	BUTZ, Karin, RISTRIANI, Tutik, HENGSTERMANN, Arnd, DENK, Claudia, SCHEFFNER, Martin, HOPPE-SEYLER, Felix
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Apoptosis - genetics Biological and medical sciences Cancer Cell death Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Classical genetics, quantitative genetics, hybrids DNA-Binding Proteins Fundamental and applied biological sciences. Psychology Gene silencing Genes Genetic Therapy - methods Genetics of eukaryotes. Biological and molecular evolution HeLa Cells - drug effects HeLa Cells - virology Human Human papillomavirus Humans Molecular and cellular biology Oncogene Proteins, Viral - drug effects Oncogene Proteins, Viral - genetics Oncogenes Proteins Retinoblastoma Protein - genetics Retinoblastoma Protein - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - pharmacology RNA-mediated interference siRNA Therapeutic targets Transfection Transformed cells Tumor Cells, Cultured Tumor Stem Cell Assay Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
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