Impaired Fracture Healing in the Absence of TNF‐α Signaling: The Role of TNF‐α in Endochondral Cartilage Resorption

TNF‐α is a major inflammatory factor that is induced in response to injury, and it contributes to the normal regulatory processes of bone resorption. The role of TNF‐α during fracture healing was examined in wild‐type and TNF‐α receptor (p55−/−/p75−/−)‐deficient mice. The results show that TNF‐α pla...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of bone and mineral research 2003-09, Vol.18 (9), p.1584-1592
Hauptverfasser:	Gerstenfeld, LC, Cho, T‐J, Kon, T, Aizawa, T, Tsay, A, Fitch, J, Barnes, GL, Graves, DT, Einhorn, TA
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - genetics Antigens, CD - physiology Apoptosis Base Sequence Biological and medical sciences Bone Resorption - genetics Bone Resorption - pathology Bone Resorption - physiopathology Cartilage - physiology Cartilage - physiopathology chondrocyte apoptosis Chondrocytes - pathology Chondrocytes - physiology fracture healing Fracture Healing - physiology Injuries of the limb. Injuries of the spine Male Medical sciences Mice Mice, Knockout Mice, Transgenic Receptors, Tumor Necrosis Factor - deficiency Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor - physiology Receptors, Tumor Necrosis Factor, Type I Receptors, Tumor Necrosis Factor, Type II resorption RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction TNF‐α Traumas. Diseases due to physical agents Tumor Necrosis Factor-alpha - deficiency Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!