Transvascular Osmotic Flow Reflected by Changes in Plasma Oncotic Pressure of Anesthetized Dog
To assess overall bodily transvascular fluid flow due to osmotic imbalance between blood and interstitial fluid during or after addition of hypertonic saline, sugar-, albumin-and dextran solutions or CO2 mixture to blood, arterial blood colloid osmotic pressure (COP) of anesthetized dogs was continu...
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| Veröffentlicht in: | Japanese journal of physiology 1981, Vol.31(1), pp.67-82 |
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| container_start_page | 67 |
| container_title | Japanese journal of physiology |
| container_volume | 31 |
| creator | KAKIUCHI, Yoshihiro NAKAJIMA, Susumu ARAI, Takashi HORIMOTO, Masashi KIKUCHI, Yuji KOYAMA, Tomiyasu |
| description | To assess overall bodily transvascular fluid flow due to osmotic imbalance between blood and interstitial fluid during or after addition of hypertonic saline, sugar-, albumin-and dextran solutions or CO2 mixture to blood, arterial blood colloid osmotic pressure (COP) of anesthetized dogs was continuously measured with a needle-type colloid osmometer.Plasma volume change (ΔVp) was estimated from the changes in either the equivalent albumin concentration (C) or the albumin concentration equivalent to plasma COP, which was well confirmed in inanimate model experiments.Carbon dioxide inhalation caused RBC swelling (1.5% volume increase/10mmHg of PCO2).Intravenous injection of hypertonic solutions resulted in transient osmotic flow (8.5±2.2ml/g of solute per kg of animal weight by NaCl, and 1.7±0.4 by glucose), and albumin and dextran also induced fluid flow (1.3±0.4 by albumin and 2.2±0.7 by dextran), which depended on van't Hoff's law and reflection coefficient of solutes. |
| doi_str_mv | 10.2170/jjphysiol.31.67 |
| format | Article |
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Capillary Permeability ; Carbon Dioxide ; Dogs ; Erythrocyte Volume ; Glucose ; Hypertonic Solutions ; Isotonic Solutions ; Mathematics ; Models, Biological ; osmoregulation ; Osmotic Pressure ; Rheology ; Saline Solution, Hypertonic ; Serum Albumin - analysis</subject><ispartof>The Japanese Journal of Physiology, 1981, Vol.31(1), pp.67-82</ispartof><rights>Physiological Society of Japan</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4927-518cb8ebd897d250b3f2619ea491dd762598bad64fbe7c5238abade4cc0ae5423</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6792407$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KAKIUCHI, Yoshihiro</creatorcontrib><creatorcontrib>NAKAJIMA, Susumu</creatorcontrib><creatorcontrib>ARAI, Takashi</creatorcontrib><creatorcontrib>HORIMOTO, Masashi</creatorcontrib><creatorcontrib>KIKUCHI, Yuji</creatorcontrib><creatorcontrib>KOYAMA, Tomiyasu</creatorcontrib><title>Transvascular Osmotic Flow Reflected by Changes in Plasma Oncotic Pressure of Anesthetized Dog</title><title>Japanese journal of physiology</title><addtitle>Jpn J Physiol</addtitle><description>To assess overall bodily transvascular fluid flow due to osmotic imbalance between blood and interstitial fluid during or after addition of hypertonic saline, sugar-, albumin-and dextran solutions or CO2 mixture to blood, arterial blood colloid osmotic pressure (COP) of anesthetized dogs was continuously measured with a needle-type colloid osmometer.Plasma volume change (ΔVp) was estimated from the changes in either the equivalent albumin concentration (C) or the albumin concentration equivalent to plasma COP, which was well confirmed in inanimate model experiments.Carbon dioxide inhalation caused RBC swelling (1.5% volume increase/10mmHg of PCO2).Intravenous injection of hypertonic solutions resulted in transient osmotic flow (8.5±2.2ml/g of solute per kg of animal weight by NaCl, and 1.7±0.4 by glucose), and albumin and dextran also induced fluid flow (1.3±0.4 by albumin and 2.2±0.7 by dextran), which depended on van't Hoff's law and reflection coefficient of solutes.</description><subject>Animals</subject><subject>Capillary Permeability</subject><subject>Carbon Dioxide</subject><subject>Dogs</subject><subject>Erythrocyte Volume</subject><subject>Glucose</subject><subject>Hypertonic Solutions</subject><subject>Isotonic Solutions</subject><subject>Mathematics</subject><subject>Models, Biological</subject><subject>osmoregulation</subject><subject>Osmotic Pressure</subject><subject>Rheology</subject><subject>Saline Solution, Hypertonic</subject><subject>Serum Albumin - analysis</subject><issn>0021-521X</issn><issn>1881-1396</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFv0zAUhy0EGmVw5oTkE7d0fnZiJ8epbAxpUic0JE5YjvPSpnKS4peAyl-Pt1blyMXW0-97Pz19jL0HsZRgxNVut98eqBvDUsFSmxdsAWUJGahKv2QLISRkhYTvr9kbol0ada7zC3ahTSVzYRbsx2N0A_1y5OfgIl9TP06d57dh_M2_YhvQT9jw-sBXWzdskHg38IfgqHd8Pfhn9iEi0RyRjy2_HpCmLU7dn7T1ady8Za9aFwjfnf5L9u325nF1l92vP39ZXd9nPq-kyQoofV1i3ZSVaWQhatVKDRW6vIKmMVoWVVm7RudtjcYXUpUujZh7LxwWuVSX7OOxdx_Hn3O6wfYdeQzBDTjOZI3SidLwXxAKZZIjk8CrI-jjSBSxtfvY9S4eLAj7pN6e1VsF9nnjw6l6rntszvzJdcrvjvmOJrfBc-5ishjwXx9UhXjqhOOjzRnxWxctDuovnG2dDQ</recordid><startdate>1981</startdate><enddate>1981</enddate><creator>KAKIUCHI, Yoshihiro</creator><creator>NAKAJIMA, Susumu</creator><creator>ARAI, Takashi</creator><creator>HORIMOTO, Masashi</creator><creator>KIKUCHI, Yuji</creator><creator>KOYAMA, Tomiyasu</creator><general>THE PHYSIOLOGICAL SOCIETY OF JAPAN</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1981</creationdate><title>Transvascular Osmotic Flow Reflected by Changes in Plasma Oncotic Pressure of Anesthetized Dog</title><author>KAKIUCHI, Yoshihiro ; 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| identifier | ISSN: 0021-521X |
| ispartof | The Japanese Journal of Physiology, 1981, Vol.31(1), pp.67-82 |
| issn | 0021-521X 1881-1396 |
| language | eng |
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| source | MEDLINE; EZB Electronic Journals Library |
| subjects | Animals Capillary Permeability Carbon Dioxide Dogs Erythrocyte Volume Glucose Hypertonic Solutions Isotonic Solutions Mathematics Models, Biological osmoregulation Osmotic Pressure Rheology Saline Solution, Hypertonic Serum Albumin - analysis |
| title | Transvascular Osmotic Flow Reflected by Changes in Plasma Oncotic Pressure of Anesthetized Dog |
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