CHEMICAL MODIFICATION OF FORTIMICINS: II. SELECTIVE PROTECTION OF FORTIMICINS A AND B

CHEMICAL MODIFICATION OF FORTIMICINS: II. SELECTIVE PROTECTION OF FORTIMICINS A AND B

The four amino groups of fortimicin B(4) could be differentiated from each other and 2'-N-benzyloxycarbonyl-, 2', 6'-di-N-benzyloxycarbonyl-, 2'-N-tert-butoxycarbonyl-, 6'-N-tert-butoxycarbonyl- and 2', 6'-di-N-tert-butoxycarbonyl-fortimicin B (7, 8, 16, 18, 17) we...

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Veröffentlicht in:Journal of antibiotics 1981, Vol.34(5), pp.513-521
Hauptverfasser: SATO, MORIYUKI, MOCHIDA, KENICHI, MORI, YASUKI, SHIRAHATA, KUNIKATSU
Format: Artikel
Sprache:eng
Schlagworte:
Aminoglycosides
Anti-Bacterial Agents
Chemical Phenomena
Chemistry
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Conformation
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Zusammenfassung:The four amino groups of fortimicin B(4) could be differentiated from each other and 2'-N-benzyloxycarbonyl-, 2', 6'-di-N-benzyloxycarbonyl-, 2'-N-tert-butoxycarbonyl-, 6'-N-tert-butoxycarbonyl- and 2', 6'-di-N-tert-butoxycarbonyl-fortimicin B (7, 8, 16, 18, 17) were prepared from 4. From these fortimicin B derivatives, selectively protected fortimicin A derivatives 13, 15, 21, 22 and 25 were prepared by combination of procedures of benzyloxycarbonylation or tert-butoxycarbonylation, 4-N-glycylation.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.34.513