Sodium appetite in sheep induced by cerebral ventricular infusion of angiotensin: comparison with sodium deficiency
Intraventricular administration of supraphysiological amounts of renin, nerve growth factor preparation, or angiotensin II greatly increased the consumption of water and hypertonic sodium bicarbonate solution by sheep. These effects were antagonized by intraventricular administration of drugs that p...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1981-10, Vol.214 (4517), p.195-197 |
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| container_issue | 4517 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 214 |
| creator | Coghean, J. P. Considine, P. J. Denton, D. A. Fei, D. T. W. Leksell, L. G. McKinley, M. J. Muller, A. F. Tarjan, Eva Weisinger, R. S. Bradshaw, R. A. |
| description | Intraventricular administration of supraphysiological amounts of renin, nerve growth factor preparation, or angiotensin II greatly increased the consumption of water and hypertonic sodium bicarbonate solution by sheep. These effects were antagonized by intraventricular administration of drugs that prevent the formation of angiotensin II or block its receptors. The fact that these angiotensinblocking drugs did not change the sodium intake of sodium-deficient sheep challenges the idea that central angiotensin action is involved in sodium appetite due to a deficiency. |
| doi_str_mv | 10.1126/science.6169149 |
| format | Article |
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P. ; Considine, P. J. ; Denton, D. A. ; Fei, D. T. W. ; Leksell, L. G. ; McKinley, M. J. ; Muller, A. F. ; Tarjan, Eva ; Weisinger, R. S. ; Bradshaw, R. A.</creator><creatorcontrib>Coghean, J. P. ; Considine, P. J. ; Denton, D. A. ; Fei, D. T. W. ; Leksell, L. G. ; McKinley, M. J. ; Muller, A. F. ; Tarjan, Eva ; Weisinger, R. S. ; Bradshaw, R. A.</creatorcontrib><description>Intraventricular administration of supraphysiological amounts of renin, nerve growth factor preparation, or angiotensin II greatly increased the consumption of water and hypertonic sodium bicarbonate solution by sheep. These effects were antagonized by intraventricular administration of drugs that prevent the formation of angiotensin II or block its receptors. The fact that these angiotensinblocking drugs did not change the sodium intake of sodium-deficient sheep challenges the idea that central angiotensin action is involved in sodium appetite due to a deficiency.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.6169149</identifier><identifier>PMID: 6169149</identifier><language>eng</language><publisher>United States: The American Association for the Advancement Science</publisher><subject>Angiotensin II - pharmacology ; Animals ; Appetite ; Appetite - drug effects ; Brain ; Dosage ; Drinking Behavior - drug effects ; Initial value theorem ; Injections, Intraventricular ; Intravenous injections ; Kidneys ; Lateral ventricles ; Nerve Growth Factors - pharmacology ; Nerves ; Physiological aspects ; Renin - pharmacology ; Saralasin - pharmacology ; Sheep ; Sodium ; Sodium (Nutrient) ; Sodium - deficiency ; Sodium - metabolism ; Sodium in the body ; Teprotide - pharmacology</subject><ispartof>Science (American Association for the Advancement of Science), 1981-10, Vol.214 (4517), p.195-197</ispartof><rights>Copyright 1981 The American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-5b5eeed9054d7cd4628d6c710d83d7a3e0e2145df2da48c4c45039caa99a07fd3</citedby><cites>FETCH-LOGICAL-c402t-5b5eeed9054d7cd4628d6c710d83d7a3e0e2145df2da48c4c45039caa99a07fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1686574$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1686574$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6169149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coghean, J. P.</creatorcontrib><creatorcontrib>Considine, P. J.</creatorcontrib><creatorcontrib>Denton, D. A.</creatorcontrib><creatorcontrib>Fei, D. T. W.</creatorcontrib><creatorcontrib>Leksell, L. G.</creatorcontrib><creatorcontrib>McKinley, M. J.</creatorcontrib><creatorcontrib>Muller, A. F.</creatorcontrib><creatorcontrib>Tarjan, Eva</creatorcontrib><creatorcontrib>Weisinger, R. S.</creatorcontrib><creatorcontrib>Bradshaw, R. A.</creatorcontrib><title>Sodium appetite in sheep induced by cerebral ventricular infusion of angiotensin: comparison with sodium deficiency</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Intraventricular administration of supraphysiological amounts of renin, nerve growth factor preparation, or angiotensin II greatly increased the consumption of water and hypertonic sodium bicarbonate solution by sheep. These effects were antagonized by intraventricular administration of drugs that prevent the formation of angiotensin II or block its receptors. The fact that these angiotensinblocking drugs did not change the sodium intake of sodium-deficient sheep challenges the idea that central angiotensin action is involved in sodium appetite due to a deficiency.</description><subject>Angiotensin II - pharmacology</subject><subject>Animals</subject><subject>Appetite</subject><subject>Appetite - drug effects</subject><subject>Brain</subject><subject>Dosage</subject><subject>Drinking Behavior - drug effects</subject><subject>Initial value theorem</subject><subject>Injections, Intraventricular</subject><subject>Intravenous injections</subject><subject>Kidneys</subject><subject>Lateral ventricles</subject><subject>Nerve Growth Factors - pharmacology</subject><subject>Nerves</subject><subject>Physiological aspects</subject><subject>Renin - pharmacology</subject><subject>Saralasin - pharmacology</subject><subject>Sheep</subject><subject>Sodium</subject><subject>Sodium (Nutrient)</subject><subject>Sodium - deficiency</subject><subject>Sodium - metabolism</subject><subject>Sodium in the body</subject><subject>Teprotide - pharmacology</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1v1DAQhi0EKkvhzAWQT1xQWn_FiblVK76kSj2Uni2vPdm6SuxgO8D-ewyJ6MkjPc-MR-8g9JqSC0qZvMzWQ7BwIalUVKgnaEeJahvFCH-KdoRw2fSka5-jFzk_EFKZ4mfobNN3KN9G55cJm3mG4gtgH3C-B5hr4RYLDh9O2EKCQzIj_gmhJG-X0aTKhyX7GHAcsAlHHwuE7MNHbOM0m-RzRb98ucd5_cHB4P8te3qJng1mzPBqe8_R3edP3_dfm-ubL9_2V9eNFYSVpj20AOAUaYXrrBOS9U7ajhLXc9cZDgQYFa0bmDOit8KKlnBljVHKkG5w_By9X-fOKf5YIBc9-WxhHE2AuGTdcSloz1kVP6zi0YygfbAxFPhdbBxHOIKuS-1v9BWrORJKqn252jbFnBMMek5-MumkKdF_j6K3o-gt5drxdltkOUzg_vuP_M3KH3KJ6XGc7GXbiYrfrXgwUZtjjVbf3VLVM9LXbtXxP3GvnhQ</recordid><startdate>19811009</startdate><enddate>19811009</enddate><creator>Coghean, J. P.</creator><creator>Considine, P. J.</creator><creator>Denton, D. A.</creator><creator>Fei, D. T. W.</creator><creator>Leksell, L. G.</creator><creator>McKinley, M. J.</creator><creator>Muller, A. F.</creator><creator>Tarjan, Eva</creator><creator>Weisinger, R. S.</creator><creator>Bradshaw, R. A.</creator><general>The American Association for the Advancement Science</general><general>American Association for the Advancement of Science</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19811009</creationdate><title>Sodium appetite in sheep induced by cerebral ventricular infusion of angiotensin: comparison with sodium deficiency</title><author>Coghean, J. P. ; Considine, P. J. ; Denton, D. A. ; Fei, D. T. W. ; Leksell, L. G. ; McKinley, M. J. ; Muller, A. F. ; Tarjan, Eva ; Weisinger, R. S. ; Bradshaw, R. 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J.</au><au>Denton, D. A.</au><au>Fei, D. T. W.</au><au>Leksell, L. G.</au><au>McKinley, M. J.</au><au>Muller, A. F.</au><au>Tarjan, Eva</au><au>Weisinger, R. S.</au><au>Bradshaw, R. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sodium appetite in sheep induced by cerebral ventricular infusion of angiotensin: comparison with sodium deficiency</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1981-10-09</date><risdate>1981</risdate><volume>214</volume><issue>4517</issue><spage>195</spage><epage>197</epage><pages>195-197</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Intraventricular administration of supraphysiological amounts of renin, nerve growth factor preparation, or angiotensin II greatly increased the consumption of water and hypertonic sodium bicarbonate solution by sheep. These effects were antagonized by intraventricular administration of drugs that prevent the formation of angiotensin II or block its receptors. The fact that these angiotensinblocking drugs did not change the sodium intake of sodium-deficient sheep challenges the idea that central angiotensin action is involved in sodium appetite due to a deficiency.</abstract><cop>United States</cop><pub>The American Association for the Advancement Science</pub><pmid>6169149</pmid><doi>10.1126/science.6169149</doi><tpages>3</tpages></addata></record> |
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| ispartof | Science (American Association for the Advancement of Science), 1981-10, Vol.214 (4517), p.195-197 |
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| language | eng |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Angiotensin II - pharmacology Animals Appetite Appetite - drug effects Brain Dosage Drinking Behavior - drug effects Initial value theorem Injections, Intraventricular Intravenous injections Kidneys Lateral ventricles Nerve Growth Factors - pharmacology Nerves Physiological aspects Renin - pharmacology Saralasin - pharmacology Sheep Sodium Sodium (Nutrient) Sodium - deficiency Sodium - metabolism Sodium in the body Teprotide - pharmacology |
| title | Sodium appetite in sheep induced by cerebral ventricular infusion of angiotensin: comparison with sodium deficiency |
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