Mitogen-activated protein kinase inhibition and cardioplegia-cardiopulmonary bypass reduce coronary myogenic tone

Cardioplegia-cardiopulmonary bypass (C/CPB) is associated with coronary microcirculatory dysfunction. Regulation of the microcirculation includes myogenic tone. Mitogen-activated protein kinases (MAPK) have been implicated in coronary vasomotor function. We hypothesized that vasomotor dysfunction of...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2003-09, Vol.108 (10), p.348-353
Hauptverfasser:	KHAN, Tanveer A, BIANCHI, Cesario, RUEL, VOISINE, Pierre, JIANYI LI, LIDDICOAT, John R, SELLKE, Frank W
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anesthesia Anesthesia depending on type of surgery Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Arterioles - anatomy & histology Arterioles - enzymology Arterioles - physiology Biological and medical sciences Cardiopulmonary Bypass Cell Cycle Proteins Coronary Vessels - anatomy & histology Coronary Vessels - enzymology Coronary Vessels - physiology Dual Specificity Phosphatase 1 Enzyme Inhibitors - pharmacology Female Flavonoids - pharmacology Heart Arrest, Induced Humans Immediate-Early Proteins - metabolism Male MAP Kinase Kinase 1 MAP Kinase Kinase 2 Medical sciences Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Phosphoprotein Phosphatases Protein Phosphatase 1 Protein Tyrosine Phosphatases - metabolism Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - antagonists & inhibitors Thoracic and cardiovascular surgery. Cardiopulmonary bypass
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