Cellular and chemical reduction products of misonidazole

Misonidazole is readily reduced by zinc dust in aqueous solution in the presence of ammonium chloride. High pressure liquid chromatographic (HPLC) separation of the reduction mixture revealed the presence of three products. These were identified as the hydroxylamine, amine and the hydrazo derivative...

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Veröffentlicht in:	Chemico-biological interactions 1981-08, Vol.36 (2), p.141-151
Hauptverfasser:	Varghese, A.J., Whitmore, G.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biotransformation Cells, Cultured Chromatography, High Pressure Liquid Chromatography, Paper Cricetinae Cricetulus Female Misonidazole - metabolism Nitroimidazoles - metabolism Ovary Oxidation-Reduction Protein Binding
Online-Zugang:	Volltext
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