High pressure induces superoxide production in isolated arteries via protein kinase C-dependent activation of NAD(P)H oxidase

Oxidative stress seems to be present in all forms of hypertension. Thus, we tested the hypothesis that high intraluminal pressure (Pi) itself, by activating vascular oxidases, elicits increased superoxide (O2*-) production interfering with flow-induced dilation. Isolated, cannulated rat femoral arte...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2003-09, Vol.108 (10), p.1253-1258
Hauptverfasser:	UNGVARI, Zoltan, CSISZAR, Anna, AN HUANG, KAMINSKI, Pawel M, WOLIN, Michael S, KOLLER, Akos
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Flow Velocity - physiology Blood Pressure Calcium - metabolism Calcium - pharmacology Cardiology. Vascular system Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Enzyme Activation - physiology Enzyme Activators - pharmacology Enzyme Inhibitors - pharmacology Experimental diseases Femoral Artery - drug effects Femoral Artery - physiopathology Fluorescent Dyes Hypertension - physiopathology In Vitro Techniques Male Medical sciences Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism NADH, NADPH Oxidoreductases - antagonists & inhibitors NADH, NADPH Oxidoreductases - metabolism NADPH Oxidases Oxidoreductases - metabolism Phosphoproteins - metabolism Phosphorylation - drug effects Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Rats Rats, Wistar Superoxide Dismutase - pharmacology Superoxides - metabolism Vasodilation - drug effects Vasodilation - physiology
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