Left Ventricular Diastolic Function and Cardiac Performance during Exercise in Patients with Acromegaly
Exercise-induced impairment of left ventricular (LV) ejection fraction is common in patients with acromegaly and normal resting systolic function. This study aimed to clarify whether diastolic dysfunction plays a role in the abnormal adaptation to exercise in these patients. Forty-eight patients wit...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2003-09, Vol.88 (9), p.4105-4109 |
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| creator | Spinelli, Letizia Petretta, Mario Verderame, Giuseppe Carbone, Giuseppe Venetucci, Angela Assunta Petretta, Andrea Acampa, Wanda Bonaduce, Domenico Colao, Annamaria Cuocolo, Alberto |
| description | Exercise-induced impairment of left ventricular (LV) ejection fraction is common in patients with acromegaly and normal resting systolic function. This study aimed to clarify whether diastolic dysfunction plays a role in the abnormal adaptation to exercise in these patients. Forty-eight patients with active acromegaly underwent LV radionuclide angiography at rest and during exercise. Doppler echocardiography was also performed to assess LV mass index and diastolic function by combined analysis of mitral and pulmonary flow velocity curves. LV ejection fraction at peak exercise was related to rest ejection fraction (r = 0.78; P < 0.001), peak filling rate (r = 0.55; P < 0.01), LV mass index (r = −0.56; P < 0.001), and the difference between duration of diastolic reverse pulmonary vein flow and mitral flow at atrial contraction (Δ duration) (r = −0.54; P < 0.01). At stepwise regression analysis, rest ejection fraction and Δ duration were the only variables that independently influenced (P < 0.001) ejection fraction at peak exercise.
Diastolic dysfunction is important in determining cardiac performance during exercise in patients with acromegaly and normal resting systolic function. Combined analysis of pulmonary vein and mitral flow velocity curves allows the identification of impaired LV diastolic function in such patients. |
| doi_str_mv | 10.1210/jc.2003-030462 |
| format | Article |
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Diastolic dysfunction is important in determining cardiac performance during exercise in patients with acromegaly and normal resting systolic function. Combined analysis of pulmonary vein and mitral flow velocity curves allows the identification of impaired LV diastolic function in such patients.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2003-030462</identifier><identifier>PMID: 12970271</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Acromegaly - diagnostic imaging ; Acromegaly - physiopathology ; Adult ; Biological and medical sciences ; Blood Flow Velocity - physiology ; Echocardiography ; Echocardiography, Doppler ; Endocrinopathies ; Exercise - physiology ; Female ; Heart - diagnostic imaging ; Heart - physiopathology ; Heart Function Tests ; Hormones - blood ; Human Growth Hormone - blood ; Humans ; Hypertrophy, Left Ventricular - diagnostic imaging ; Hypertrophy, Left Ventricular - physiopathology ; Hypothalamus. Hypophysis. Epiphysis (diseases) ; Male ; Medical sciences ; Middle Aged ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Radionuclide Angiography ; Regression Analysis ; Ventricular Function, Left - physiology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2003-09, Vol.88 (9), p.4105-4109</ispartof><rights>Copyright © 2003 by The Endocrine Society</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4833-321a5a30b6fe8a1bef262e972b0a531ddab78df07b907482502040492504bd133</citedby><cites>FETCH-LOGICAL-c4833-321a5a30b6fe8a1bef262e972b0a531ddab78df07b907482502040492504bd133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15149182$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12970271$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spinelli, Letizia</creatorcontrib><creatorcontrib>Petretta, Mario</creatorcontrib><creatorcontrib>Verderame, Giuseppe</creatorcontrib><creatorcontrib>Carbone, Giuseppe</creatorcontrib><creatorcontrib>Venetucci, Angela Assunta</creatorcontrib><creatorcontrib>Petretta, Andrea</creatorcontrib><creatorcontrib>Acampa, Wanda</creatorcontrib><creatorcontrib>Bonaduce, Domenico</creatorcontrib><creatorcontrib>Colao, Annamaria</creatorcontrib><creatorcontrib>Cuocolo, Alberto</creatorcontrib><title>Left Ventricular Diastolic Function and Cardiac Performance during Exercise in Patients with Acromegaly</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Exercise-induced impairment of left ventricular (LV) ejection fraction is common in patients with acromegaly and normal resting systolic function. This study aimed to clarify whether diastolic dysfunction plays a role in the abnormal adaptation to exercise in these patients. Forty-eight patients with active acromegaly underwent LV radionuclide angiography at rest and during exercise. Doppler echocardiography was also performed to assess LV mass index and diastolic function by combined analysis of mitral and pulmonary flow velocity curves. LV ejection fraction at peak exercise was related to rest ejection fraction (r = 0.78; P < 0.001), peak filling rate (r = 0.55; P < 0.01), LV mass index (r = −0.56; P < 0.001), and the difference between duration of diastolic reverse pulmonary vein flow and mitral flow at atrial contraction (Δ duration) (r = −0.54; P < 0.01). At stepwise regression analysis, rest ejection fraction and Δ duration were the only variables that independently influenced (P < 0.001) ejection fraction at peak exercise.
Diastolic dysfunction is important in determining cardiac performance during exercise in patients with acromegaly and normal resting systolic function. Combined analysis of pulmonary vein and mitral flow velocity curves allows the identification of impaired LV diastolic function in such patients.</description><subject>Acromegaly - diagnostic imaging</subject><subject>Acromegaly - physiopathology</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity - physiology</subject><subject>Echocardiography</subject><subject>Echocardiography, Doppler</subject><subject>Endocrinopathies</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Heart - diagnostic imaging</subject><subject>Heart - physiopathology</subject><subject>Heart Function Tests</subject><subject>Hormones - blood</subject><subject>Human Growth Hormone - blood</subject><subject>Humans</subject><subject>Hypertrophy, Left Ventricular - diagnostic imaging</subject><subject>Hypertrophy, Left Ventricular - physiopathology</subject><subject>Hypothalamus. Hypophysis. Epiphysis (diseases)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Radionuclide Angiography</subject><subject>Regression Analysis</subject><subject>Ventricular Function, Left - physiology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2P0zAQxS0EYsvClSPyBW4p44_E8XFVdgGpEnsAxM1ynEnr4iTFTlT2v8cllfaEsGTZln7zxvMeIa8ZrBln8P7g1hxAFCBAVvwJWTEty0IxrZ6SFQBnhVb8xxV5kdIBgElZiufkinGtgCu2IrstdhP9jsMUvZuDjfSDt2kag3f0bh7c5MeB2qGlGxtbbx29x9iNsbeDQ9rO0Q87evsbo_MJqR_ovZ18Fkv05Kc9vXFx7HFnw8NL8qyzIeGry3lNvt3dft18KrZfPn7e3GwLJ2shCsGZLa2ApuqwtqzBjlcc8wgN2FKwtrWNqtsOVKNByZqXwEGC1Pkim5YJcU3eLbrHOP6aMU2m98lhCHbAcU5GiUooxvR_QVbrsq6YzOB6AfMsKUXszDH63sYHw8CcMzAHZ84ZmCWDXPDmojw3PbaP-MX0DLy9ADY5G7qYzfTpkSuZ1Kw-C8mFO41hwph-hvmE0ezRhmlvIC9Zqbo49wadX0Xefy0olzIc2tHlhPAYMSVzGOc4ZO__9e8_PRevWw</recordid><startdate>200309</startdate><enddate>200309</enddate><creator>Spinelli, Letizia</creator><creator>Petretta, Mario</creator><creator>Verderame, Giuseppe</creator><creator>Carbone, Giuseppe</creator><creator>Venetucci, Angela Assunta</creator><creator>Petretta, Andrea</creator><creator>Acampa, Wanda</creator><creator>Bonaduce, Domenico</creator><creator>Colao, Annamaria</creator><creator>Cuocolo, Alberto</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>200309</creationdate><title>Left Ventricular Diastolic Function and Cardiac Performance during Exercise in Patients with Acromegaly</title><author>Spinelli, Letizia ; Petretta, Mario ; Verderame, Giuseppe ; Carbone, Giuseppe ; Venetucci, Angela Assunta ; Petretta, Andrea ; Acampa, Wanda ; Bonaduce, Domenico ; Colao, Annamaria ; Cuocolo, Alberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4833-321a5a30b6fe8a1bef262e972b0a531ddab78df07b907482502040492504bd133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Acromegaly - diagnostic imaging</topic><topic>Acromegaly - physiopathology</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity - physiology</topic><topic>Echocardiography</topic><topic>Echocardiography, Doppler</topic><topic>Endocrinopathies</topic><topic>Exercise - physiology</topic><topic>Female</topic><topic>Heart - diagnostic imaging</topic><topic>Heart - physiopathology</topic><topic>Heart Function Tests</topic><topic>Hormones - blood</topic><topic>Human Growth Hormone - blood</topic><topic>Humans</topic><topic>Hypertrophy, Left Ventricular - diagnostic imaging</topic><topic>Hypertrophy, Left Ventricular - physiopathology</topic><topic>Hypothalamus. Hypophysis. Epiphysis (diseases)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Radionuclide Angiography</topic><topic>Regression Analysis</topic><topic>Ventricular Function, Left - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spinelli, Letizia</creatorcontrib><creatorcontrib>Petretta, Mario</creatorcontrib><creatorcontrib>Verderame, Giuseppe</creatorcontrib><creatorcontrib>Carbone, Giuseppe</creatorcontrib><creatorcontrib>Venetucci, Angela Assunta</creatorcontrib><creatorcontrib>Petretta, Andrea</creatorcontrib><creatorcontrib>Acampa, Wanda</creatorcontrib><creatorcontrib>Bonaduce, Domenico</creatorcontrib><creatorcontrib>Colao, Annamaria</creatorcontrib><creatorcontrib>Cuocolo, Alberto</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spinelli, Letizia</au><au>Petretta, Mario</au><au>Verderame, Giuseppe</au><au>Carbone, Giuseppe</au><au>Venetucci, Angela Assunta</au><au>Petretta, Andrea</au><au>Acampa, Wanda</au><au>Bonaduce, Domenico</au><au>Colao, Annamaria</au><au>Cuocolo, Alberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Left Ventricular Diastolic Function and Cardiac Performance during Exercise in Patients with Acromegaly</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2003-09</date><risdate>2003</risdate><volume>88</volume><issue>9</issue><spage>4105</spage><epage>4109</epage><pages>4105-4109</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Exercise-induced impairment of left ventricular (LV) ejection fraction is common in patients with acromegaly and normal resting systolic function. This study aimed to clarify whether diastolic dysfunction plays a role in the abnormal adaptation to exercise in these patients. Forty-eight patients with active acromegaly underwent LV radionuclide angiography at rest and during exercise. Doppler echocardiography was also performed to assess LV mass index and diastolic function by combined analysis of mitral and pulmonary flow velocity curves. LV ejection fraction at peak exercise was related to rest ejection fraction (r = 0.78; P < 0.001), peak filling rate (r = 0.55; P < 0.01), LV mass index (r = −0.56; P < 0.001), and the difference between duration of diastolic reverse pulmonary vein flow and mitral flow at atrial contraction (Δ duration) (r = −0.54; P < 0.01). At stepwise regression analysis, rest ejection fraction and Δ duration were the only variables that independently influenced (P < 0.001) ejection fraction at peak exercise.
Diastolic dysfunction is important in determining cardiac performance during exercise in patients with acromegaly and normal resting systolic function. Combined analysis of pulmonary vein and mitral flow velocity curves allows the identification of impaired LV diastolic function in such patients.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>12970271</pmid><doi>10.1210/jc.2003-030462</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acromegaly - diagnostic imaging Acromegaly - physiopathology Adult Biological and medical sciences Blood Flow Velocity - physiology Echocardiography Echocardiography, Doppler Endocrinopathies Exercise - physiology Female Heart - diagnostic imaging Heart - physiopathology Heart Function Tests Hormones - blood Human Growth Hormone - blood Humans Hypertrophy, Left Ventricular - diagnostic imaging Hypertrophy, Left Ventricular - physiopathology Hypothalamus. Hypophysis. Epiphysis (diseases) Male Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Radionuclide Angiography Regression Analysis Ventricular Function, Left - physiology |
| title | Left Ventricular Diastolic Function and Cardiac Performance during Exercise in Patients with Acromegaly |
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