(Acylaryloxy)acetic acid diuretics. 3. 2,3-Dihydro-5-acyl-2-benzofurancarboxylic acids, a new class of uricosuric diuretics

The discovery that dihydroethacrynic acid and other (4-acylphenoxy)acetic acids possessed modest but significant uricosuric and diuretic activity prompted our investigation of the related 2,3-dihydro-5-acyl-2-bensofurancarboxylic acids. Synthetic routes to a number of these compounds are presented a...

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Veröffentlicht in:	Journal of medicinal chemistry 1981-07, Vol.24 (7), p.865-873
Hauptverfasser:	Hoffman, William F, Woltersdorf, Otto W, Novello, Frederick C, Cragoe, Edward J, Springer, James P, Watson, L. Sherman, Fanelli, George M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzofurans - chemical synthesis Benzofurans - pharmacology Chemical Phenomena Chemistry Diuretics - chemical synthesis Dogs Pan troglodytes Rats Species Specificity Structure-Activity Relationship Uricosuric Agents - chemical synthesis X-Ray Diffraction
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