Genetics supersedes epigenetics in colon cancer phenotype

A CpG island DNA methylator phenotype has been postulated to explain silencing of the hMLH1 DNA mismatch repair gene in cancer of the microsatellite mutator phenotype. To evaluate this model, we analyzed methylation in CpG islands from six mutator and suppressor genes, and thirty random genomic site...

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Veröffentlicht in:	Cancer cell 2003-08, Vol.4 (2), p.121-131
Hauptverfasser:	Yamashita, Kentaro, Dai, Tomoko, Dai, Yuichi, Yamamoto, Fumiichiro, Perucho, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Carrier Proteins Colorectal Neoplasms - genetics CpG Islands - genetics DNA Methylation Gene Silencing Humans Mutation - genetics MutL Protein Homolog 1 Neoplasm Proteins - genetics Nuclear Proteins Phenotype Suppression, Genetic - genetics
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