Measles Virus Genome in Infections of the Central Nervous System
The measles virus genome was traced in acute and chronic infections of the central nervous system in hamsters and humans. The extent of viral replication and gene expression was assessed by the techniques of in situ hybridization and immunofluorescence. Both replication and gene expression were rest...
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| Veröffentlicht in: | The Journal of infectious diseases 1981-08, Vol.144 (2), p.154-160 |
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| container_end_page | 160 |
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| container_issue | 2 |
| container_start_page | 154 |
| container_title | The Journal of infectious diseases |
| container_volume | 144 |
| creator | Haase, A. T. Swoveland, P. Stowring, L. Ventura, P. Johnson, K. P. Norrby, E. Gibbs, C. J. |
| description | The measles virus genome was traced in acute and chronic infections of the central nervous system in hamsters and humans. The extent of viral replication and gene expression was assessed by the techniques of in situ hybridization and immunofluorescence. Both replication and gene expression were restricted in chronically infected hamsters and in humans with subacute sclerosing panencephalitis. It is proposed that restriction playsan important role in persistence of measles virus and the slow evolution of disease in these and other slow infections. |
| doi_str_mv | 10.1093/infdis/144.2.154 |
| format | Article |
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T.</creatorcontrib><creatorcontrib>Swoveland, P.</creatorcontrib><creatorcontrib>Stowring, L.</creatorcontrib><creatorcontrib>Ventura, P.</creatorcontrib><creatorcontrib>Johnson, K. P.</creatorcontrib><creatorcontrib>Norrby, E.</creatorcontrib><creatorcontrib>Gibbs, C. J.</creatorcontrib><title>Measles Virus Genome in Infections of the Central Nervous System</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>The measles virus genome was traced in acute and chronic infections of the central nervous system in hamsters and humans. The extent of viral replication and gene expression was assessed by the techniques of in situ hybridization and immunofluorescence. Both replication and gene expression were restricted in chronically infected hamsters and in humans with subacute sclerosing panencephalitis. 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T.</creatorcontrib><creatorcontrib>Swoveland, P.</creatorcontrib><creatorcontrib>Stowring, L.</creatorcontrib><creatorcontrib>Ventura, P.</creatorcontrib><creatorcontrib>Johnson, K. P.</creatorcontrib><creatorcontrib>Norrby, E.</creatorcontrib><creatorcontrib>Gibbs, C. J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haase, A. T.</au><au>Swoveland, P.</au><au>Stowring, L.</au><au>Ventura, P.</au><au>Johnson, K. P.</au><au>Norrby, E.</au><au>Gibbs, C. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measles Virus Genome in Infections of the Central Nervous System</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1981-08</date><risdate>1981</risdate><volume>144</volume><issue>2</issue><spage>154</spage><epage>160</epage><pages>154-160</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>The measles virus genome was traced in acute and chronic infections of the central nervous system in hamsters and humans. The extent of viral replication and gene expression was assessed by the techniques of in situ hybridization and immunofluorescence. Both replication and gene expression were restricted in chronically infected hamsters and in humans with subacute sclerosing panencephalitis. It is proposed that restriction playsan important role in persistence of measles virus and the slow evolution of disease in these and other slow infections.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>7024430</pmid><doi>10.1093/infdis/144.2.154</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1981-08, Vol.144 (2), p.154-160 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73635464 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | Acute Disease Animals Antigens, Viral - analysis Brain - microbiology Cellular immunity Central nervous system Cricetinae Fluorescent Antibody Technique Genes, Viral Giant cells Infections Investigational Virology Measles virus Measles virus - genetics Measles virus - isolation & purification Measles virus - metabolism Mesocricetus Neuroglia Neurons Nucleic Acid Hybridization RNA, Viral - analysis Subacute sclerosing panencephalitis Subacute Sclerosing Panencephalitis - microbiology Viral RNA Viruses |
| title | Measles Virus Genome in Infections of the Central Nervous System |
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