Early cell-mediated immune responses to Marek’s disease virus in two chicken lines with defined major histocompatibility complex antigens
N2a and P2a chickens, resistant and susceptible to Marek’s disease (MD), respectively, were used to examine relationships between major histocompatibility complex (MHC)-restricted cytotoxic T lymphocytes (CTL) and natural killer (NK)-like cell activity with resistance to infection with Marek’s disea...
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| Veröffentlicht in: | Veterinary immunology and immunopathology 2003-10, Vol.95 (3), p.145-153 |
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| creator | Garcia-Camacho, Lucia Schat, Karel A. Brooks, Randolph Bounous, Denise I. |
| description | N2a and P2a chickens, resistant and susceptible to Marek’s disease (MD), respectively, were used to examine relationships between major histocompatibility complex (MHC)-restricted cytotoxic T lymphocytes (CTL) and natural killer (NK)-like cell activity with resistance to infection with Marek’s disease virus (MDV). Ten-day-old chickens were infected with MDV and euthanatized at selected times to evaluate for NK cell and MHC-restricted cytotoxicity. The N2a MDV-infected chickens had an early cell-mediated immune response characterized by a sustained NK-like cytotoxicity that coincided with a measurable MHC-cytotoxicity that was lower than controls. Although MHC-restricted and NK cell cytotoxicity was demonstrated in P2a MDV-infected chickens at 8
dpi, both abruptly decreased and remained low for the remainder of the 20-day experiment. The critical time point that may determine the resistance to MD appears to be within the first 2 weeks post-infection. Improvement of the chicken NK cell activity may be a good candidate for both selection and immunomodulation MD control programs. |
| doi_str_mv | 10.1016/S0165-2427(03)00140-5 |
| format | Article |
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dpi, both abruptly decreased and remained low for the remainder of the 20-day experiment. The critical time point that may determine the resistance to MD appears to be within the first 2 weeks post-infection. Improvement of the chicken NK cell activity may be a good candidate for both selection and immunomodulation MD control programs.</description><identifier>ISSN: 0165-2427</identifier><identifier>EISSN: 1873-2534</identifier><identifier>DOI: 10.1016/S0165-2427(03)00140-5</identifier><identifier>PMID: 12963275</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Cell-mediated immunity ; Chickens - immunology ; Cytotoxic lymphocytes ; Cytotoxicity, Immunologic - immunology ; Disease Susceptibility - immunology ; DNA, Viral - chemistry ; DNA, Viral - genetics ; Genetic resistance ; Glycoprotein B ; Herpesvirus 2, Gallid - genetics ; Herpesvirus 2, Gallid - immunology ; Immunity, Cellular - immunology ; Innate immunity ; Killer Cells, Natural - immunology ; Major Histocompatibility Complex - immunology ; Marek Disease - immunology ; Marek Disease - pathology ; Marek’s disease ; MHC-restricted cytotoxicity ; NK cells ; Polymerase Chain Reaction - veterinary ; Specific Pathogen-Free Organisms ; Spleen - immunology</subject><ispartof>Veterinary immunology and immunopathology, 2003-10, Vol.95 (3), p.145-153</ispartof><rights>2003 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-cd6149f81ef5939462cbebd9af11429d3eb64805a1dcf5018580f907ae4fd0e03</citedby><cites>FETCH-LOGICAL-c392t-cd6149f81ef5939462cbebd9af11429d3eb64805a1dcf5018580f907ae4fd0e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165242703001405$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12963275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garcia-Camacho, Lucia</creatorcontrib><creatorcontrib>Schat, Karel A.</creatorcontrib><creatorcontrib>Brooks, Randolph</creatorcontrib><creatorcontrib>Bounous, Denise I.</creatorcontrib><title>Early cell-mediated immune responses to Marek’s disease virus in two chicken lines with defined major histocompatibility complex antigens</title><title>Veterinary immunology and immunopathology</title><addtitle>Vet Immunol Immunopathol</addtitle><description>N2a and P2a chickens, resistant and susceptible to Marek’s disease (MD), respectively, were used to examine relationships between major histocompatibility complex (MHC)-restricted cytotoxic T lymphocytes (CTL) and natural killer (NK)-like cell activity with resistance to infection with Marek’s disease virus (MDV). Ten-day-old chickens were infected with MDV and euthanatized at selected times to evaluate for NK cell and MHC-restricted cytotoxicity. The N2a MDV-infected chickens had an early cell-mediated immune response characterized by a sustained NK-like cytotoxicity that coincided with a measurable MHC-cytotoxicity that was lower than controls. Although MHC-restricted and NK cell cytotoxicity was demonstrated in P2a MDV-infected chickens at 8
dpi, both abruptly decreased and remained low for the remainder of the 20-day experiment. The critical time point that may determine the resistance to MD appears to be within the first 2 weeks post-infection. Improvement of the chicken NK cell activity may be a good candidate for both selection and immunomodulation MD control programs.</description><subject>Animals</subject><subject>Cell-mediated immunity</subject><subject>Chickens - immunology</subject><subject>Cytotoxic lymphocytes</subject><subject>Cytotoxicity, Immunologic - immunology</subject><subject>Disease Susceptibility - immunology</subject><subject>DNA, Viral - chemistry</subject><subject>DNA, Viral - genetics</subject><subject>Genetic resistance</subject><subject>Glycoprotein B</subject><subject>Herpesvirus 2, Gallid - genetics</subject><subject>Herpesvirus 2, Gallid - immunology</subject><subject>Immunity, Cellular - immunology</subject><subject>Innate immunity</subject><subject>Killer Cells, Natural - immunology</subject><subject>Major Histocompatibility Complex - immunology</subject><subject>Marek Disease - immunology</subject><subject>Marek Disease - pathology</subject><subject>Marek’s disease</subject><subject>MHC-restricted cytotoxicity</subject><subject>NK cells</subject><subject>Polymerase Chain Reaction - veterinary</subject><subject>Specific Pathogen-Free Organisms</subject><subject>Spleen - immunology</subject><issn>0165-2427</issn><issn>1873-2534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb1uFDEURi0EIkvgEUCuEBQT_DOeGVcoigJESkQB1JbHvmadzNiL7UlIR88T8Hp5ErzZFZRpfHWlc_1J30HoJSVHlNDu3Zf6iIa1rH9D-FtCaEsa8Qit6NDzhgnePkarf8gBepbzJSFEyGF4ig4okx1nvVih36c6TbfYwDQ1M1ivC1js53kJgBPkTQwZMi4RX-gEV3e__mRsfQadAV_7tGTsAy43EZu1N1cQ8ORD5W98WWMLri4Wz_oyJrz2uUQT540ufvSTLzW0bhP8xDoU_x1Cfo6eOD1leLGfh-jbh9OvJ5-a888fz06OzxvDJSuNsR1tpRsoOCG5bDtmRhit1I7SlknLYezagQhNrXGC0EEMxEnSa2idJUD4IXq9-3eT4o8FclGzz9sGdIC4ZNXzjouWsgdBOgyS876roNiBJsWcEzi1SX7W6VZRora61L0utXWhCFf3upSod6_2ActY2_9_tfdTgfc7AGof1x6SysZDMNVUAlOUjf6BiL-hcKip</recordid><startdate>20031015</startdate><enddate>20031015</enddate><creator>Garcia-Camacho, Lucia</creator><creator>Schat, Karel A.</creator><creator>Brooks, Randolph</creator><creator>Bounous, Denise I.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20031015</creationdate><title>Early cell-mediated immune responses to Marek’s disease virus in two chicken lines with defined major histocompatibility complex antigens</title><author>Garcia-Camacho, Lucia ; Schat, Karel A. ; Brooks, Randolph ; Bounous, Denise I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-cd6149f81ef5939462cbebd9af11429d3eb64805a1dcf5018580f907ae4fd0e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Cell-mediated immunity</topic><topic>Chickens - immunology</topic><topic>Cytotoxic lymphocytes</topic><topic>Cytotoxicity, Immunologic - immunology</topic><topic>Disease Susceptibility - immunology</topic><topic>DNA, Viral - chemistry</topic><topic>DNA, Viral - genetics</topic><topic>Genetic resistance</topic><topic>Glycoprotein B</topic><topic>Herpesvirus 2, Gallid - genetics</topic><topic>Herpesvirus 2, Gallid - immunology</topic><topic>Immunity, Cellular - immunology</topic><topic>Innate immunity</topic><topic>Killer Cells, Natural - immunology</topic><topic>Major Histocompatibility Complex - immunology</topic><topic>Marek Disease - immunology</topic><topic>Marek Disease - pathology</topic><topic>Marek’s disease</topic><topic>MHC-restricted cytotoxicity</topic><topic>NK cells</topic><topic>Polymerase Chain Reaction - veterinary</topic><topic>Specific Pathogen-Free Organisms</topic><topic>Spleen - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garcia-Camacho, Lucia</creatorcontrib><creatorcontrib>Schat, Karel A.</creatorcontrib><creatorcontrib>Brooks, Randolph</creatorcontrib><creatorcontrib>Bounous, Denise I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia-Camacho, Lucia</au><au>Schat, Karel A.</au><au>Brooks, Randolph</au><au>Bounous, Denise I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early cell-mediated immune responses to Marek’s disease virus in two chicken lines with defined major histocompatibility complex antigens</atitle><jtitle>Veterinary immunology and immunopathology</jtitle><addtitle>Vet Immunol Immunopathol</addtitle><date>2003-10-15</date><risdate>2003</risdate><volume>95</volume><issue>3</issue><spage>145</spage><epage>153</epage><pages>145-153</pages><issn>0165-2427</issn><eissn>1873-2534</eissn><abstract>N2a and P2a chickens, resistant and susceptible to Marek’s disease (MD), respectively, were used to examine relationships between major histocompatibility complex (MHC)-restricted cytotoxic T lymphocytes (CTL) and natural killer (NK)-like cell activity with resistance to infection with Marek’s disease virus (MDV). Ten-day-old chickens were infected with MDV and euthanatized at selected times to evaluate for NK cell and MHC-restricted cytotoxicity. The N2a MDV-infected chickens had an early cell-mediated immune response characterized by a sustained NK-like cytotoxicity that coincided with a measurable MHC-cytotoxicity that was lower than controls. Although MHC-restricted and NK cell cytotoxicity was demonstrated in P2a MDV-infected chickens at 8
dpi, both abruptly decreased and remained low for the remainder of the 20-day experiment. The critical time point that may determine the resistance to MD appears to be within the first 2 weeks post-infection. Improvement of the chicken NK cell activity may be a good candidate for both selection and immunomodulation MD control programs.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>12963275</pmid><doi>10.1016/S0165-2427(03)00140-5</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cell-mediated immunity Chickens - immunology Cytotoxic lymphocytes Cytotoxicity, Immunologic - immunology Disease Susceptibility - immunology DNA, Viral - chemistry DNA, Viral - genetics Genetic resistance Glycoprotein B Herpesvirus 2, Gallid - genetics Herpesvirus 2, Gallid - immunology Immunity, Cellular - immunology Innate immunity Killer Cells, Natural - immunology Major Histocompatibility Complex - immunology Marek Disease - immunology Marek Disease - pathology Marek’s disease MHC-restricted cytotoxicity NK cells Polymerase Chain Reaction - veterinary Specific Pathogen-Free Organisms Spleen - immunology |
| title | Early cell-mediated immune responses to Marek’s disease virus in two chicken lines with defined major histocompatibility complex antigens |
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