Effects of Panax ginseng extract on lipid metabolism in humans
The purpose of this study was to examine the effects of Panax ginseng extract (PGE) on lipid metabolism in humans by measuring cholesterol, malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT). Serum total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and plasma...
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| Veröffentlicht in: | Pharmacological research 2003-11, Vol.48 (5), p.511-513 |
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| creator | Kim, Seung-Hwan Park, Kyung-Shin |
| description | The purpose of this study was to examine the effects of Panax ginseng extract (PGE) on lipid metabolism in humans by measuring cholesterol, malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT). Serum total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and plasma MDA levels were decreased by administration of PGE for 8 weeks (6
g per day), however, high density lipoprotein (HDL) was increased. Those results suggest that hypolipidemic effect of PGE is associated with a decrease in TC, TG, LDL, MDA levels and an increase in HDL. These findings support scientific claims that ginseng has the hypolipidemic potential. Administration of PGE increased SOD and CAT activities while decreased MDA level indicating that antioxidant potential of PGE might induce hypolipidemic effect as one of action mechanism. |
| doi_str_mv | 10.1016/S1043-6618(03)00189-0 |
| format | Article |
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g per day), however, high density lipoprotein (HDL) was increased. Those results suggest that hypolipidemic effect of PGE is associated with a decrease in TC, TG, LDL, MDA levels and an increase in HDL. These findings support scientific claims that ginseng has the hypolipidemic potential. Administration of PGE increased SOD and CAT activities while decreased MDA level indicating that antioxidant potential of PGE might induce hypolipidemic effect as one of action mechanism.</description><identifier>ISSN: 1043-6618</identifier><identifier>EISSN: 1096-1186</identifier><identifier>DOI: 10.1016/S1043-6618(03)00189-0</identifier><identifier>PMID: 12967598</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Antioxidants - metabolism ; Catalase - blood ; Cholesterol - blood ; Cholesterol, HDL - blood ; Erythrocytes - enzymology ; Humans ; Lipid Metabolism ; Lipoproteins, LDL - blood ; Male ; Malondialdehyde - blood ; Panax - chemistry ; PGE ; Plant Extracts - pharmacology ; Superoxide Dismutase - blood ; Triglycerides - blood</subject><ispartof>Pharmacological research, 2003-11, Vol.48 (5), p.511-513</ispartof><rights>2003 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-ffc8d0887f4011f20d8909edf5bbbdfa02955cbbd5e4668fdc8b4dd9dabcbf523</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1043-6618(03)00189-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12967598$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Seung-Hwan</creatorcontrib><creatorcontrib>Park, Kyung-Shin</creatorcontrib><title>Effects of Panax ginseng extract on lipid metabolism in humans</title><title>Pharmacological research</title><addtitle>Pharmacol Res</addtitle><description>The purpose of this study was to examine the effects of Panax ginseng extract (PGE) on lipid metabolism in humans by measuring cholesterol, malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT). Serum total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and plasma MDA levels were decreased by administration of PGE for 8 weeks (6
g per day), however, high density lipoprotein (HDL) was increased. Those results suggest that hypolipidemic effect of PGE is associated with a decrease in TC, TG, LDL, MDA levels and an increase in HDL. These findings support scientific claims that ginseng has the hypolipidemic potential. Administration of PGE increased SOD and CAT activities while decreased MDA level indicating that antioxidant potential of PGE might induce hypolipidemic effect as one of action mechanism.</description><subject>Adult</subject><subject>Antioxidants - metabolism</subject><subject>Catalase - blood</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Erythrocytes - enzymology</subject><subject>Humans</subject><subject>Lipid Metabolism</subject><subject>Lipoproteins, LDL - blood</subject><subject>Male</subject><subject>Malondialdehyde - blood</subject><subject>Panax - chemistry</subject><subject>PGE</subject><subject>Plant Extracts - pharmacology</subject><subject>Superoxide Dismutase - blood</subject><subject>Triglycerides - blood</subject><issn>1043-6618</issn><issn>1096-1186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKxDAUhoMozjj6CEpWoovqSdukyUaRYbzAgIK6DmkuY6SXMWllfHs7F3Dp6vyL75yf8yF0SuCKAGHXrwTyLGGM8AvILgEIFwnsoTEBwRJCONtf5x0yQkcxfgKAyAkcohFJBSuo4GN0M3PO6i7i1uEX1agVXvgm2maB7aoLSne4bXDll97g2naqbCsfa-wb_NHXqonH6MCpKtqT3Zyg9_vZ2_QxmT8_PE3v5onOC9ElzmlugPPC5UCIS8FwAcIaR8uyNE5BKijVQ6Q2Z4w7o3mZGyOMKnXpaJpN0Pn27jK0X72Nnax91LaqVGPbPsoiYxklaTGAdAvq0MYYrJPL4GsVfiQBuRYnN-Lk2oqETG7EDWGCznYFfVlb87e1MzUAt1vADm9-extk1N422hofBoHStP6fil_sLX4k</recordid><startdate>20031101</startdate><enddate>20031101</enddate><creator>Kim, Seung-Hwan</creator><creator>Park, Kyung-Shin</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031101</creationdate><title>Effects of Panax ginseng extract on lipid metabolism in humans</title><author>Kim, Seung-Hwan ; Park, Kyung-Shin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-ffc8d0887f4011f20d8909edf5bbbdfa02955cbbd5e4668fdc8b4dd9dabcbf523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Antioxidants - metabolism</topic><topic>Catalase - blood</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Erythrocytes - enzymology</topic><topic>Humans</topic><topic>Lipid Metabolism</topic><topic>Lipoproteins, LDL - blood</topic><topic>Male</topic><topic>Malondialdehyde - blood</topic><topic>Panax - chemistry</topic><topic>PGE</topic><topic>Plant Extracts - pharmacology</topic><topic>Superoxide Dismutase - blood</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Seung-Hwan</creatorcontrib><creatorcontrib>Park, Kyung-Shin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Seung-Hwan</au><au>Park, Kyung-Shin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Panax ginseng extract on lipid metabolism in humans</atitle><jtitle>Pharmacological research</jtitle><addtitle>Pharmacol Res</addtitle><date>2003-11-01</date><risdate>2003</risdate><volume>48</volume><issue>5</issue><spage>511</spage><epage>513</epage><pages>511-513</pages><issn>1043-6618</issn><eissn>1096-1186</eissn><abstract>The purpose of this study was to examine the effects of Panax ginseng extract (PGE) on lipid metabolism in humans by measuring cholesterol, malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT). Serum total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and plasma MDA levels were decreased by administration of PGE for 8 weeks (6
g per day), however, high density lipoprotein (HDL) was increased. Those results suggest that hypolipidemic effect of PGE is associated with a decrease in TC, TG, LDL, MDA levels and an increase in HDL. These findings support scientific claims that ginseng has the hypolipidemic potential. Administration of PGE increased SOD and CAT activities while decreased MDA level indicating that antioxidant potential of PGE might induce hypolipidemic effect as one of action mechanism.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>12967598</pmid><doi>10.1016/S1043-6618(03)00189-0</doi><tpages>3</tpages></addata></record> |
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| ispartof | Pharmacological research, 2003-11, Vol.48 (5), p.511-513 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Antioxidants - metabolism Catalase - blood Cholesterol - blood Cholesterol, HDL - blood Erythrocytes - enzymology Humans Lipid Metabolism Lipoproteins, LDL - blood Male Malondialdehyde - blood Panax - chemistry PGE Plant Extracts - pharmacology Superoxide Dismutase - blood Triglycerides - blood |
| title | Effects of Panax ginseng extract on lipid metabolism in humans |
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