Gated binding of ligands to proteins

The binding of ligands to proteins often occurs at rates that approach the diffusion-controlled limit 1 . For spherical molecules with negligible interactions apart from isotropic reactivity on contact, the diffusion-controlled rate constant is K D ≡ 4π RD , where R is the distance between molecular...

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Bibliographische Detailangaben

Veröffentlicht in:	Nature (London) 1981-09, Vol.293 (5830), p.316-317
Hauptverfasser:	McCammon, J. Andrew, Northrup, Scott H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Humanities and Social Sciences letter Ligands Motion multidisciplinary Probability Protein Binding proteins Science Science (multidisciplinary)
Online-Zugang:	Volltext
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