Effect of single inhalation of a salbutamol, ipratropium bromide and beclomethasone on mucociliary clearance in patients with chronic obstructive airway disease
Chronic obstructive airway disease (COAD) is associated with hyperplasia and hypertrophy of the mucus producing glands. The beneficial effect of inhaled drug may be due to improved mucociliary function. The present study was done to evaluate the effect of salbutamol, ipratropium bromide and beclomet...
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| Veröffentlicht in: | Indian journal of chest diseases & allied sciences 2003-10, Vol.45 (4), p.241-246 |
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| container_title | Indian journal of chest diseases & allied sciences |
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| creator | GULERIA, R RAJENDRA SINGH, Th SINHA, Sanjeev PADHY, K GUPTA, K PANDE, J. N |
| description | Chronic obstructive airway disease (COAD) is associated with hyperplasia and hypertrophy of the mucus producing glands. The beneficial effect of inhaled drug may be due to improved mucociliary function. The present study was done to evaluate the effect of salbutamol, ipratropium bromide and beclomethasone dipropionate inhalation on mucociliary clearance in patients with COAD.
Ten patients of COAD were taken up, two patients however did not complete the study. Salbutamol, ipratropium bromide, beclomethasone dipropionate and placebo inhalation were given randomly to each patient on four separate days. Radioaerosol inhalation lung cine-scintigraphy after inhalation of the different drugs was followed up to two hours and than after 24 hours.
There was no significant visually noticeable increased mucociliary clearance on any of the days. Two patients showed definite steep slope in the time activity curves with salbutamol as compared to other drugs or placebo. All the quantitative indices analysed at the end of one hour and two hours for the three drugs were comparable to placebo.
A single dose of inhaled salbutamol, ipratropium bromide and beclomethasone dipropionate has no appreciable effect on mucociliary clearance in patients with COAD. |
| format | Article |
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Ten patients of COAD were taken up, two patients however did not complete the study. Salbutamol, ipratropium bromide, beclomethasone dipropionate and placebo inhalation were given randomly to each patient on four separate days. Radioaerosol inhalation lung cine-scintigraphy after inhalation of the different drugs was followed up to two hours and than after 24 hours.
There was no significant visually noticeable increased mucociliary clearance on any of the days. Two patients showed definite steep slope in the time activity curves with salbutamol as compared to other drugs or placebo. All the quantitative indices analysed at the end of one hour and two hours for the three drugs were comparable to placebo.
A single dose of inhaled salbutamol, ipratropium bromide and beclomethasone dipropionate has no appreciable effect on mucociliary clearance in patients with COAD.</description><identifier>ISSN: 0377-9343</identifier><identifier>PMID: 12962458</identifier><identifier>CODEN: ICDSD6</identifier><language>eng</language><publisher>Delhi: Vallabhbhai Patel Chest Institute</publisher><subject>Administration, Inhalation ; Albuterol - administration & dosage ; Albuterol - pharmacology ; Albuterol - therapeutic use ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Beclomethasone - administration & dosage ; Beclomethasone - pharmacology ; Beclomethasone - therapeutic use ; Biological and medical sciences ; Bronchodilator Agents - administration & dosage ; Bronchodilator Agents - pharmacology ; Bronchodilator Agents - therapeutic use ; Chronic obstructive pulmonary disease, asthma ; Dose-Response Relationship, Drug ; Humans ; Ipratropium - administration & dosage ; Ipratropium - pharmacology ; Ipratropium - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Mucociliary Clearance - drug effects ; Pneumology ; Pulmonary Disease, Chronic Obstructive - diagnostic imaging ; Pulmonary Disease, Chronic Obstructive - drug therapy ; Radionuclide Imaging</subject><ispartof>Indian journal of chest diseases & allied sciences, 2003-10, Vol.45 (4), p.241-246</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15136263$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12962458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GULERIA, R</creatorcontrib><creatorcontrib>RAJENDRA SINGH, Th</creatorcontrib><creatorcontrib>SINHA, Sanjeev</creatorcontrib><creatorcontrib>PADHY, K</creatorcontrib><creatorcontrib>GUPTA, K</creatorcontrib><creatorcontrib>PANDE, J. N</creatorcontrib><title>Effect of single inhalation of a salbutamol, ipratropium bromide and beclomethasone on mucociliary clearance in patients with chronic obstructive airway disease</title><title>Indian journal of chest diseases & allied sciences</title><addtitle>Indian J Chest Dis Allied Sci</addtitle><description>Chronic obstructive airway disease (COAD) is associated with hyperplasia and hypertrophy of the mucus producing glands. The beneficial effect of inhaled drug may be due to improved mucociliary function. The present study was done to evaluate the effect of salbutamol, ipratropium bromide and beclomethasone dipropionate inhalation on mucociliary clearance in patients with COAD.
Ten patients of COAD were taken up, two patients however did not complete the study. Salbutamol, ipratropium bromide, beclomethasone dipropionate and placebo inhalation were given randomly to each patient on four separate days. Radioaerosol inhalation lung cine-scintigraphy after inhalation of the different drugs was followed up to two hours and than after 24 hours.
There was no significant visually noticeable increased mucociliary clearance on any of the days. Two patients showed definite steep slope in the time activity curves with salbutamol as compared to other drugs or placebo. All the quantitative indices analysed at the end of one hour and two hours for the three drugs were comparable to placebo.
A single dose of inhaled salbutamol, ipratropium bromide and beclomethasone dipropionate has no appreciable effect on mucociliary clearance in patients with COAD.</description><subject>Administration, Inhalation</subject><subject>Albuterol - administration & dosage</subject><subject>Albuterol - pharmacology</subject><subject>Albuterol - therapeutic use</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Beclomethasone - administration & dosage</subject><subject>Beclomethasone - pharmacology</subject><subject>Beclomethasone - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Bronchodilator Agents - administration & dosage</subject><subject>Bronchodilator Agents - pharmacology</subject><subject>Bronchodilator Agents - therapeutic use</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Dose-Response Relationship, Drug</subject><subject>Humans</subject><subject>Ipratropium - administration & dosage</subject><subject>Ipratropium - pharmacology</subject><subject>Ipratropium - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mucociliary Clearance - drug effects</subject><subject>Pneumology</subject><subject>Pulmonary Disease, Chronic Obstructive - diagnostic imaging</subject><subject>Pulmonary Disease, Chronic Obstructive - drug therapy</subject><subject>Radionuclide Imaging</subject><issn>0377-9343</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1KxDAUhbtQnHH0FSQbXVlIk7ZpljKMPyC40XW5TW-cSJrUJHWYt_FR7eCIqwOX735wzkm2pFyIXPKSL7LzGD8oZVUpi7NsUTBZs7Jqltn3RmtUiXhNonHvFolxW7CQjHeHI5AItpsSDN7eEjMGSMGPZhpIF_xgeiTgetKhsn7AtIXoHZL5dZiUV8YaCHuiLEIApw5uMs5qdCmSnUlborbBO6OI72IKk0rmaxaasIM96U1EiHiRnWqwES-Pucre7jev68f8-eXhaX33nI9FxVIuKZWyw5KLqmQMVM1432tZ8F6qRlFeawGUUgHQFI1QXddoSWtWibLWqkHJV9nNr3cM_nPCmNrBRIXWgkM_xVbwmpdCNjN4dQSnbsC-HYMZ5pbt36YzcH0EICqw-lDdxH-uKnjNas5_AAmJgsA</recordid><startdate>200310</startdate><enddate>200310</enddate><creator>GULERIA, R</creator><creator>RAJENDRA SINGH, Th</creator><creator>SINHA, Sanjeev</creator><creator>PADHY, K</creator><creator>GUPTA, K</creator><creator>PANDE, J. N</creator><general>Vallabhbhai Patel Chest Institute</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200310</creationdate><title>Effect of single inhalation of a salbutamol, ipratropium bromide and beclomethasone on mucociliary clearance in patients with chronic obstructive airway disease</title><author>GULERIA, R ; RAJENDRA SINGH, Th ; SINHA, Sanjeev ; PADHY, K ; GUPTA, K ; PANDE, J. N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p152t-90099be4375422ac623ddf913d9c8c036f7a0007aa8187cbb8f90625746fc8e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Administration, Inhalation</topic><topic>Albuterol - administration & dosage</topic><topic>Albuterol - pharmacology</topic><topic>Albuterol - therapeutic use</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Beclomethasone - administration & dosage</topic><topic>Beclomethasone - pharmacology</topic><topic>Beclomethasone - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Bronchodilator Agents - administration & dosage</topic><topic>Bronchodilator Agents - pharmacology</topic><topic>Bronchodilator Agents - therapeutic use</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Dose-Response Relationship, Drug</topic><topic>Humans</topic><topic>Ipratropium - administration & dosage</topic><topic>Ipratropium - pharmacology</topic><topic>Ipratropium - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mucociliary Clearance - drug effects</topic><topic>Pneumology</topic><topic>Pulmonary Disease, Chronic Obstructive - diagnostic imaging</topic><topic>Pulmonary Disease, Chronic Obstructive - drug therapy</topic><topic>Radionuclide Imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GULERIA, R</creatorcontrib><creatorcontrib>RAJENDRA SINGH, Th</creatorcontrib><creatorcontrib>SINHA, Sanjeev</creatorcontrib><creatorcontrib>PADHY, K</creatorcontrib><creatorcontrib>GUPTA, K</creatorcontrib><creatorcontrib>PANDE, J. N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Indian journal of chest diseases & allied sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GULERIA, R</au><au>RAJENDRA SINGH, Th</au><au>SINHA, Sanjeev</au><au>PADHY, K</au><au>GUPTA, K</au><au>PANDE, J. N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of single inhalation of a salbutamol, ipratropium bromide and beclomethasone on mucociliary clearance in patients with chronic obstructive airway disease</atitle><jtitle>Indian journal of chest diseases & allied sciences</jtitle><addtitle>Indian J Chest Dis Allied Sci</addtitle><date>2003-10</date><risdate>2003</risdate><volume>45</volume><issue>4</issue><spage>241</spage><epage>246</epage><pages>241-246</pages><issn>0377-9343</issn><coden>ICDSD6</coden><abstract>Chronic obstructive airway disease (COAD) is associated with hyperplasia and hypertrophy of the mucus producing glands. The beneficial effect of inhaled drug may be due to improved mucociliary function. The present study was done to evaluate the effect of salbutamol, ipratropium bromide and beclomethasone dipropionate inhalation on mucociliary clearance in patients with COAD.
Ten patients of COAD were taken up, two patients however did not complete the study. Salbutamol, ipratropium bromide, beclomethasone dipropionate and placebo inhalation were given randomly to each patient on four separate days. Radioaerosol inhalation lung cine-scintigraphy after inhalation of the different drugs was followed up to two hours and than after 24 hours.
There was no significant visually noticeable increased mucociliary clearance on any of the days. Two patients showed definite steep slope in the time activity curves with salbutamol as compared to other drugs or placebo. All the quantitative indices analysed at the end of one hour and two hours for the three drugs were comparable to placebo.
A single dose of inhaled salbutamol, ipratropium bromide and beclomethasone dipropionate has no appreciable effect on mucociliary clearance in patients with COAD.</abstract><cop>Delhi</cop><pub>Vallabhbhai Patel Chest Institute</pub><pmid>12962458</pmid><tpages>6</tpages></addata></record> |
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| subjects | Administration, Inhalation Albuterol - administration & dosage Albuterol - pharmacology Albuterol - therapeutic use Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Beclomethasone - administration & dosage Beclomethasone - pharmacology Beclomethasone - therapeutic use Biological and medical sciences Bronchodilator Agents - administration & dosage Bronchodilator Agents - pharmacology Bronchodilator Agents - therapeutic use Chronic obstructive pulmonary disease, asthma Dose-Response Relationship, Drug Humans Ipratropium - administration & dosage Ipratropium - pharmacology Ipratropium - therapeutic use Male Medical sciences Middle Aged Mucociliary Clearance - drug effects Pneumology Pulmonary Disease, Chronic Obstructive - diagnostic imaging Pulmonary Disease, Chronic Obstructive - drug therapy Radionuclide Imaging |
| title | Effect of single inhalation of a salbutamol, ipratropium bromide and beclomethasone on mucociliary clearance in patients with chronic obstructive airway disease |
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