Xylylated dimers of putrescine and polyamines: influence of the polyamine backbone on spermidine transport inhibition

Dimeric norspermidine and spermidine derivatives are strong competitive inhibitors of polyamine transport. A xylyl tether was used for the dimerization of various triamines and spermine via a secondary amino group, and of putrescine via an ether or an amino group. Dimerization of putrescine moieties...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2003-10, Vol.13 (19), p.3267-3271
Hauptverfasser:	Covassin, Laurence, Desjardins, Michel, Soulet, Denis, Charest-Gaudreault, René, Audette, Marie, Poulin, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Biological Transport - drug effects Biological Transport - physiology Dimerization General aspects Medical sciences Pharmacology. Drug treatments Polyamines - chemistry Polyamines - metabolism Polyamines - pharmacology Putrescine - chemistry Putrescine - metabolism Putrescine - pharmacology Spermidine - antagonists & inhibitors Spermidine - metabolism Xylenes - chemistry Xylenes - metabolism Xylenes - pharmacology
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