Heterostereocomplexes Prepared from d-PLA and l-PLA and Leuprolide. II. Release of Leuprolide

Reversible stereoselective complexes were spontaneously obtained from mixing acetonitrile solutions of enatiomeric d-poly(lactic acid) (d-PLA), l-poly(lactic acid) (l-PLA), and leuprolide, a l-configured nonapeptide LHRH analogue. The complex spontaneously aggregated and precipitated in high yields...

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Veröffentlicht in:	Biomacromolecules 2003-09, Vol.4 (5), p.1316-1320
Hauptverfasser:	Slager, Joram, Domb, Abraham J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Applied sciences Biological and medical sciences Chemical Precipitation Delayed-Action Preparations - chemistry Delayed-Action Preparations - pharmacokinetics Drug Carriers - chemistry Drug Carriers - pharmacokinetics Drug Monitoring Exact sciences and technology General pharmacology Kinetics Leuprolide - administration & dosage Leuprolide - chemistry Leuprolide - pharmacokinetics Male Medical sciences Organic polymers Peptides - administration & dosage Peptides - chemistry Peptides - pharmacokinetics Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Polyesters - chemistry Properties and characterization Rats Rats, Wistar Special properties (catalyst, reagent or carrier) Stereoisomerism Testosterone - blood
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