Unsuspected Role of the Brain Morphogenetic Gene Otx1 in Hematopoiesis

Otx1 belongs to the paired class of homeobox genes and plays a pivotal role in brain development. Here, we show that Otx1 is expressed in hematopoietic pluripotent and erythroid progenitor cells. Moreover, bone marrow cells from mice lacking Otx1 exhibit a cell-autonomous impairment of the erythroid...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-09, Vol.100 (18), p.10299-10303
Hauptverfasser:	Levantini, Elena, Giorgetti, Alessandra, Cerisoli, Francesco, Traggiai, Elisabetta, Guidi, Alessandra, Martin, Richard, Acampora, Dario, Aplan, Peter D., Keller, Gordon, Simeone, Antonio, Iscove, Norman N., Hoang, Trang, Magli, Maria Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Basic Helix-Loop-Helix Transcription Factors Biological Sciences Blood Blood cells Bone marrow Bone marrow cells Brain Cells DNA-Binding Proteins - genetics Erythroid cells Erythroid progenitor cells Erythropoiesis Female Genes Hematopoiesis Hematopoietic stem cells Homeodomain Proteins - genetics Homeodomain Proteins - physiology Mice Mice, Inbred C57BL Molecular Sequence Data Otx Transcription Factors Pluripotent stem cells Progenitor cells Proto-Oncogene Proteins - genetics Studies T-Cell Acute Lymphocytic Leukemia Protein 1 Transcription Factors - genetics Transcription Factors - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!